1.1.1.153: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

This is an abbreviated version, for detailed information about sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming), go to the full flat file.

Reaction

L-erythro-7,8-dihydrobiopterin
+
NADP+
=
sepiapterin
+
NADPH
+
H+

Synonyms

AKR1B1, reductase, sepiapterin, sepiapterin reductase, SPR, SR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

KM Value

KM Value on EC 1.1.1.153 - sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.007
1'-hydroxy-2'-oxopropyltetrahydropterin
-
pH 7.4, 37C
-
0.0021
1,2-naphthoquinone
-
wild-type, pH 6.4, 37C
0.027
1,4-Naphthoquinone
-
wild-type, pH 6.4, 37C
0.118
1-phenyl-1,2-propanedione
-
cofactor NADH
0.086
2,3-dimethoxynaphthalene-1,4-dione
-
wild-type, pH 6.4, 37C
5.19
2,4-Pentanedione
-
-
0.0143
2-amino-6-(2-hydroxypropanoyl)pteridin-4(1H)-one
-
pH 6.4, 25C
0.0077
7,8-dihydrobiopterin
-
pH 10.4, 25C
0.00082
9,10-phenanthrene quinone
-
-
0.0019 - 0.464
9,10-phenanthrenequinone
29
acetoin
-
-
1.1
acetophenone
-
-
0.0183 - 0.02
benzil
0.043
benzylacetone
-
-
1 - 4
diacetyl
0.057
dihydrobiopterin
-
at pH 10.4
0.008
lactoyltetrahydropterin
-
pH 7.4, 37C
0.0872 - 0.18
menadione
4.4
methylglyoxal
-
-
0.0057 - 0.077
NADP+
0.0014 - 0.052
NADPH
0.43
p-nitrobenzaldehyde
-
-
0.75
p-quinone
-
-
0.59
Phenylglyoxal
-
-
0.0218
phenylpropanedione
-
; pH 6.4, 25C
0.14
propiophenone
-
-
0.002
pyruvoyltetrahydropterin
-
pH 7.4, 37C
0.00018 - 0.169
sepiapterin
additional information
additional information
-