1.1.1.153: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

This is an abbreviated version, for detailed information about sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming), go to the full flat file.

Reaction

L-erythro-7,8-dihydrobiopterin
+
NADP+
=
sepiapterin
+
NADPH
+
H+

Synonyms

AKR1B1, reductase, sepiapterin, sepiapterin reductase, SPR, SR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

Inhibitors

Inhibitors on EC 1.1.1.153 - sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2-naphthoquinone
-
-
1-norepinephrine
-
; 3 mM: 30% inhibition
2,4-dinitrophenol
6,7-Diethylpterin-H2
-
-
6,7-dimethyldihydropterin
-
0.05 mM: 70% inhibition
6,7-dimethyllumazine
-
slight
6,7-dimethylpterin
-
0.05 mM: 46% inhibition; 46% inhibition of the reductive reaction at 0.05 mM
6,7-dimethylpterin-H2
-
70% inhibition of the reductive reaction at 0.05 mM
6-Carboxypterin
6-Hydroxymethylpterin
-
0.05 mM: 23% inhibition; 23% inhibition of the reductive reaction at 0.05 mM
6-methyldihydropterin
-
0.05 mM: 59% inhibition
6-methylpterin
-
10% inhibition of the reductive reaction at 0.05 mM; slight
6-Methylpterin-H2
-
59% inhibition of the reductive reaction at 0.05 mM
7-Methylpterin
-
0.05 mM: 18% inhibition; 18% inhibition of the reductive reaction at 0.05 mM
9,10-phenanthrenequinone
-
-
acetic acid
alpha-ketoglutarate
-
slight, IC50 5 mM
Benzoic acid
-
0.03 mM: 40% inhibition; 40% inhibition of the reductive reaction at 0.03 mM
benzoquinone
-
-
biopterin
-
0.05 mM: 24% inhibition; 24% inhibition of the reductive reaction at 0.05 mM
biopterin-H2
-
31% inhibition of the reductive reaction at 0.05 mM
catecholamine
-
-
Cibacron Blue 3G-A
-
IC50 0.01 mM
D,L-Lactic acid
-
0.03 mM, 20% inhibition
D-erythro-neopterin
-
14% inhibition of the reductive reaction at 0.05 mM
D-erythro-neopterin-H2
-
7% inhibition of the reductive reaction at 0.05 mM
dicoumarol
dihydrobiopterin
dihydroxanthopterin
-
slight
DL-lactic acid
-
20% inhibition of the reductive reaction at 0.03 mM
dopamine
-
slight; slight inhibition
Ethacrynic acid
-
IC50 0.03 mM
Fe3+
-
1 mM inhibits entirely
formic acid
-
slight
Hg2+
-
IC50 0.00009 mM
Indoleamine
-
-
indomethacin
iodoacetate
-
72% inhibition of the reductive reaction at 0.1 mM
Isosepiapterin
-
83% inhibition of the reductive reaction at 0.05 mM; IC50 0.0065 mM, 0.05 mM: 83% inhibition
Isoxanthopterin
-
0.05 mM: very slight
KCN
-
25% inhibition of the reductive reaction at 2.5 mM; slight
L-erythro-dihydroneopterin
-
0.05 mM: 29% inhibition, D-isomer: slight inhibition
-
L-Erythro-neopterin
-
0.05 mM: 21% inhibition, D-isomer: slight inhibition; 21% inhibition of the reductive reaction at 0.05 mM
L-Erythro-neopterin-H2
-
29% inhibition of the reductive reaction at 0.05 mM
Leucopterin
-
0.05 mM: 21% inhibition; 21% inhibition of the reductive reaction at 0.05 mM
Melatonin
monoiodoacetate
-
-
N-acetyl-L-noradrenaline
-
weak inhibitor, N-acetyl-L-adrenaline does not bind enzyme
N-acetyl-p-tyramine
-
weak, N-acetyl-m-tyramine shows strong inhibition
N-acetyl-serotonin
-
complete inhibition
N-acetyldopamine
N-acetylphenethylamine
-
weak
N-acetylserotonin
N-acetyltryptamine
-
slight, N-acetyltryptophan does not bind enzyme
n-butyric acid
-
IC50 0.032 mM, pH 6.5
N-chloroacetyldopamine
-
strong inhibitor
N-chloroacetylserotonin
-
strong competitive inhibitor
N-chloroserotonin
strong inhibitor
N-ethylmaleimide
-
-
N-lactoyldopamine
-
potent inhibitor
N-methoxyacetylserotonin
N-pyruvoyldopamine
-
potent inhibitor
n-valeric acid
-
IC50 0.25 mM, pH 6.5
NADP+
-
competitive inhibition at fixed concentration with varied NADPH, noncompetitive with varied sepiapterin
NADPH
NaN3
-
15% inhibition of the reductive reaction at 5 mM; slight
NEM
-
35% inhibition of the reductive reaction at 0.1 mM, 88% at 1 mM
oxaloacetate
-
p-chloromercuribenzoate
-
-
p-mercuribenzoate
-
0.1 mM, 93% inhibition
PCMB
-
93% inhibition of the reductive reaction at 0.01 mM
Phenobarbital
-
slight, IC50 0.6 mM
phenylquinone
-
-
Propionamide
-
0.03 mM, 14% inhibition; 14% inhibition of the reductive reaction at 0.03 mM
propionic acid
pterin
-
0.05 mM: 18% inhibition; 18% inhibition of the reductive reaction at 0.05 mM
pyrazole
-
slight, IC50 1 mM
Pyruvic acid
-
9% inhibition of the reductive reaction at 0.03 mM; slight
rutin
-
IC50 0.06 mM
sepiapterin
serotonin
-
-
Sn2+
-
1 mM inhibits entirely
Sodium acetate
-
-
Xanthopterin
-
slight
Xanthopterin B2
-
slight
Xanthopterin-B2
-
12% inhibition of the reductive reaction at 0.05 mM
xanthopterin-H2
-
9% inhibition of the reductive reaction at 0.05 mM
Zn2+
-
IC50 0.4 mM
additional information
-