1.1.1.153: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

This is an abbreviated version, for detailed information about sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming), go to the full flat file.

Reaction

L-erythro-7,8-dihydrobiopterin
+
NADP+
=
sepiapterin
+
NADPH
+
H+

Synonyms

AKR1B1, reductase, sepiapterin, sepiapterin reductase, SPR, SR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

IC50 Value

IC50 Value on EC 1.1.1.153 - sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0089
1,2-naphthoquinone
Homo sapiens
-
wild-type, pH 6.7, 37°C
0.014 - 0.03
6-Carboxypterin
0.0036
9,10-phenanthrenequinone
Homo sapiens
-
wild-type, pH 6.7, 37°C
0.45
acetic acid
Equus caballus
-
IC50 0.45 mM, pH 6.5
5
alpha-ketoglutarate
Rattus norvegicus
-
slight, IC50 5 mM
0.0028
benzoquinone
Homo sapiens
-
wild-type, pH 6.7, 37°C
0.1
Cd2+
Rattus norvegicus
-
IC50 0.1 mM
0.01
Cibacron Blue 3G-A
Rattus norvegicus
-
IC50 0.01 mM
0.0002 - 0.0006
dicoumarol
0.03
Ethacrynic acid
Rattus norvegicus
-
IC50 0.03 mM
0.00009
Hg2+
Rattus norvegicus
-
IC50 0.00009 mM
0.0081 - 0.06
indomethacin
0.0065
Isosepiapterin
Equus caballus
-
IC50 0.0065 mM, 0.05 mM: 83% inhibition
0.1
Melatonin
Bombyx mori
-
recombinant enzyme, in 100 mM potassium phosphate buffer (pH 6.4), at 37°C
0.0006 - 0.2
N-acetylserotonin
0.032
n-butyric acid
Equus caballus
-
IC50 0.032 mM, pH 6.5
0.25
n-valeric acid
Equus caballus
-
IC50 0.25 mM, pH 6.5
0.6
Phenobarbital
Rattus norvegicus
-
slight, IC50 0.6 mM
0.0016
phenylquinone
Homo sapiens
-
wild-type, pH 6.7, 37°C
0.0045 - 0.3
propionic acid
1
pyrazole
Rattus norvegicus
-
slight, IC50 1 mM
0.06
rutin
Rattus norvegicus
-
IC50 0.06 mM
0.4
Zn2+
Rattus norvegicus
-
IC50 0.4 mM