1.1.1.153: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

This is an abbreviated version, for detailed information about sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming), go to the full flat file.

Reaction

L-erythro-7,8-dihydrobiopterin
+
NADP+
=
sepiapterin
+
NADPH
+
H+

Synonyms

AKR1B1, reductase, sepiapterin, sepiapterin reductase, SPR, SR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

Cloned

Cloned on EC 1.1.1.153 - sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
chromosomal location 2p14-2p12, RT-PCR expression analysis
-
expressed in COS-7 and RNA-64A cells
-
expressed in Escherichia coli
-
expressed in Escherichia coli BL21 (DE3) cells
-
expressed in Escherichia coli BL21(DE3) cells
-
expressed in Escherichia coli BL21(DE3)/pLysS
expressed in Escherichia coli BL21(DE3, pLysS)
-
expression of His-tagged native and selenomethionine-labeled enzyme in Escherichia coli strain BL21(DE3)
-
gene SPR, chromosomal location at 2p13, genomic structure, DNA and amino acid sequence determination of wild-type and mutant enzymes
-
host cells transfected with sense, antisense and inverse antisense oligodeoxynucleotides
-
recombinant protein expressed in Escherichia coli
site-directed mutagenesis, recombinant protein expressed in Escherichia coli GI724
-