1.1.1.151: 21-hydroxysteroid dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about 21-hydroxysteroid dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

21-hydroxy steroid (NADP) dehydrogenase, 21-hydroxy steroid dehydrogenase, 21-hydroxy steroid dehydrogenase (NADP), NADP-21-hydroxysteroid dehydrogenase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.151 21-hydroxysteroid dehydrogenase (NADP+)

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Results	in table
1	CAS Registry Number
1	Cofactor
1	General Stability
5	Inhibitors
7	KM Value [mM]
1	Organism
1	pH Optimum
1	Purification (Commentary)
1	Reaction
3	Reaction Type
1	Reference
1	Source Tissue
1	Storage Stability
7	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name
1	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 1.1.1.151 - 21-hydroxysteroid dehydrogenase (NADP+)

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11beta,17-dihydroxy-pregn-4,11-diene-3,20,21-trione + NADPH

11beta,17,21-trihydroxy-pregn-4,11-diene-3,20-dione + NADP+

Ovis aries aries

i.e. 21-dehydro-delta1-cortisol

286004

21-hydroxy-delta1-cortisol

286004

11beta,17-dihydroxy-pregn-4-ene-3,20,21-trione + NADPH

11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+

Ovis aries aries

i.e. 21-dehydrocortisol

286004

i.e. cortisol

286004

11beta-hydroxy-pregn-4-ene-3,20,21-trione + NADPH

11beta,21-dihydroxy-pregn-4-ene-3,20-dione + NADP+

Ovis aries aries

i.e. 21-dehydrocorticosterone

286004

21-hydroxycorticosterone

286004

17-hydroxy-pregn-4-ene-3,11,20,21-tetraone + NADPH + H+

17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADP+

Ovis aries aries

286004

17-hydroxy-pregn-4-ene-3,20,21-trione + NADPH

17,21-dihydroxy-pregn-4-ene-3,20-dione + NADP+

Ovis aries aries

i.e. 21-dehydro-11-deoxycortisol

286004

i.e. 21-hydroxy-11-deoxycortisol

286004

17alpha-hydroxy-pregn-4-ene-3,11,20,21-tetraone + NADPH

17alpha,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADP+

Ovis aries aries

i.e. 21-dehydrocortisone, marked dependence on the nature of steroids

286004

i.e. cortisone

286004

pregn-4-ene-3,20,21-trione + NADPH

21-hydroxy-pregn-4-ene-3,20-dione + NADP+

Ovis aries aries

i.e. 21-dehydro-11-deoxy-corticosterone

286004

21-hydroxy-11-deoxy-corticosterone

286004