1.1.1.151: 21-hydroxysteroid dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about 21-hydroxysteroid dehydrogenase (NADP+), go to the full flat file.

Reaction

pregnan-21-ol
+
NADP+
=
pregnan-21-al
+
NADPH
+
H+

Synonyms

21-hydroxy steroid (NADP) dehydrogenase, 21-hydroxy steroid dehydrogenase, 21-hydroxy steroid dehydrogenase (NADP), NADP-21-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.151 21-hydroxysteroid dehydrogenase (NADP+)

Substrates Products

Substrates Products on EC 1.1.1.151 - 21-hydroxysteroid dehydrogenase (NADP+)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
11beta,17-dihydroxy-pregn-4,11-diene-3,20,21-trione + NADPH
11beta,17,21-trihydroxy-pregn-4,11-diene-3,20-dione + NADP+
show the reaction diagram
Ovis aries aries
-
i.e. 21-dehydro-delta1-cortisol
21-hydroxy-delta1-cortisol
?
11beta,17-dihydroxy-pregn-4-ene-3,20,21-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
show the reaction diagram
Ovis aries aries
-
i.e. 21-dehydrocortisol
i.e. cortisol
?
11beta-hydroxy-pregn-4-ene-3,20,21-trione + NADPH
11beta,21-dihydroxy-pregn-4-ene-3,20-dione + NADP+
show the reaction diagram
Ovis aries aries
-
i.e. 21-dehydrocorticosterone
21-hydroxycorticosterone
?
17-hydroxy-pregn-4-ene-3,20,21-trione + NADPH
17,21-dihydroxy-pregn-4-ene-3,20-dione + NADP+
show the reaction diagram
Ovis aries aries
-
i.e. 21-dehydro-11-deoxycortisol
i.e. 21-hydroxy-11-deoxycortisol
?
17alpha-hydroxy-pregn-4-ene-3,11,20,21-tetraone + NADPH
17alpha,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADP+
show the reaction diagram
Ovis aries aries
-
i.e. 21-dehydrocortisone, marked dependence on the nature of steroids
i.e. cortisone
?
pregn-4-ene-3,20,21-trione + NADPH
21-hydroxy-pregn-4-ene-3,20-dione + NADP+
show the reaction diagram
Ovis aries aries
-
i.e. 21-dehydro-11-deoxy-corticosterone
21-hydroxy-11-deoxy-corticosterone
?