1.1.1.150: 21-hydroxysteroid dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about 21-hydroxysteroid dehydrogenase (NAD+), go to the full flat file.

Reaction

pregnan-21-ol
+
NAD+
=
pregnan-21-al
+
NADH
+
H+

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.150 21-hydroxysteroid dehydrogenase (NAD+)

Substrates Products

Substrates Products on EC 1.1.1.150 - 21-hydroxysteroid dehydrogenase (NAD+)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
11beta,17-dihydroxy-pregn-4,11-diene-3,20,21-trione + NADH
11beta,17,21-trihydroxy-pregn-4,11-diene-3,20-dione + NAD+
show the reaction diagram
Ovis aries aries
-
i.e. 21-dehydro-delta1-cortisol, only NAD dehydrogenase II
i.e. 21-hydroxy-delta1-cortisol
?
11beta,17-dihydroxy-pregn-4-ene-3,20,21-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
show the reaction diagram
11beta-hydroxy-pregn-4-ene-3,20,21-trione + NADH
11beta,21-dihydroxy-pregn-4-ene-3,20-dione + NAD+
show the reaction diagram
Ovis aries aries
-
i.e. 21-dehydrocorticosterone, only NAD dehydrogenase II
i.e. 21-hydroxycorticosterone
?
17-hydroxy-pregn-4-ene-3,11,20,21-tetraone + NADH
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NAD+
show the reaction diagram
Ovis aries aries
-
i.e. 21-dehydrocortisone
i.e. cortisone
?
17-hydroxy-pregn-4-ene-3,20,21-trione + NADH
17,21-dihydroxy-pregn-4-ene-3,20-dione + NAD+
show the reaction diagram
Ovis aries aries
-
i.e. 21-dehydro-11-deoxycortisol, only NAD dehydrogenase II
i.e. 21-hydroxy-11-deoxycortisol
?
5beta-pregnane-3alpha,21-diol-20-one + NAD+
5beta-pregnane-3alpha-ol-20,21-dione + NADH + H+
show the reaction diagram
dihydrotestosterone + NADH
androstanediol + NAD+
show the reaction diagram
-
substrate for retinol dehydrogenase isoform RDH12, no substrate for isoform RDH13
-
-
?
pregn-4-ene-3,20,21-trione + NADH
21-hydroxy-pregn-4-ene-3,20-dione + NAD+
show the reaction diagram
Ovis aries aries
-
i.e. 21-dehydro-11-deoxycorticosterone, only NAD dehydrogenase II
i.e. 21-hydroxy-11-deoxycorticosterone
?
additional information
?
-
-
contrary to the human enzyme, dihydrotestosterone is not a substrate for mouse retinol dehydrogenase isoform RDH12
-
-
-