1.1.1.149: 20alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 20alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

17alpha,20alpha-dihydroxypregn-4-en-3-one
+
NAD(P)+
=
17alpha-hydroxyprogesterone
+
NAD(P)H
+
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20alpha-HSD, 20alpha-HSDH, 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxysteroid dehydrogenase, 20alpha-hydroxysteroid oxidoreductase, 20alpha-OH-SDH, AKR1C1, AKR1C23, AKR1C3, aldo-keto reductase family 1 member C1, HSD1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.149 20alpha-hydroxysteroid dehydrogenase

pH Range

pH Range on EC 1.1.1.149 - 20alpha-hydroxysteroid dehydrogenase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4 - 10
-
-
5.4 - 7.6
-
steroid reduction e.g. 20alpha-dihydrocortisol with MES, MOPS or sodium phosphate, NADH
5.8 - 10.5
-
25C, below and above range inactivation
6.3 - 9
-
steroid oxidation e.g. cortisol with Tris hydrochloride, NAD+
6.5 - 9
-
pH 6.8 favouring progesterone to 20alpha-hydroxyprogesterone reaction and pH 8.0 vice versa