1.1.1.149: 20alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 20alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

17alpha,20alpha-dihydroxypregn-4-en-3-one
+
NAD(P)+
=
17alpha-hydroxyprogesterone
+
NAD(P)H
+
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20alpha-HSD, 20alpha-HSDH, 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxysteroid dehydrogenase, 20alpha-hydroxysteroid oxidoreductase, 20alpha-OH-SDH, AKR1C1, AKR1C23, AKR1C3, aldo-keto reductase family 1 member C1, HSD1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.149 20alpha-hydroxysteroid dehydrogenase

Turnover Number

Turnover Number on EC 1.1.1.149 - 20alpha-hydroxysteroid dehydrogenase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.178
17alpha-hydroxyprogesterone
Rattus norvegicus
-
+/-0.8
0.785
20alpha-hydroxy-5alpha-pregnan-3-one
Rattus norvegicus
-
+/-4.3
0.04 - 1.17
20alpha-hydroxyprogesterone
0.208
3alpha-hydroxy-pregnan-20-one
Rattus norvegicus
-
+/-1.6
5.91
4-Nitrobenzaldehyde
Rattus norvegicus
-
+/-33.4
7.7
9,10-phenanthrenequinone
Rattus norvegicus
-
+/-26.9
0.215
D,L-glyceraldehyde
Rattus norvegicus
-
+/-0.3
1.52
NADP+
Rattus norvegicus
-
+/-6.1
1.43
NADPH
Rattus norvegicus
-
+/-1.3
1.65
progesterone
Rattus norvegicus
-
+/-6.7