1.1.1.149: 20alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 20alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

17alpha,20alpha-dihydroxypregn-4-en-3-one
+
NAD(P)+
=
17alpha-hydroxyprogesterone
+
NAD(P)H
+
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20alpha-HSD, 20alpha-HSDH, 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxysteroid dehydrogenase, 20alpha-hydroxysteroid oxidoreductase, 20alpha-OH-SDH, AKR1C1, AKR1C23, AKR1C3, AKR1C5, aldo-keto reductase family 1 member C1, HSD1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.149 20alpha-hydroxysteroid dehydrogenase

Turnover Number

Turnover Number on EC 1.1.1.149 - 20alpha-hydroxysteroid dehydrogenase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.2
(S)-1-indanol
-
at pH 7.4 and 37C
0.217
(S)-1-tetralol
-
at pH 7.4 and 37C
0.178
17alpha-hydroxyprogesterone
-
+/-0.8
0.011
17beta-estradiol
-
at pH 7.4 and 37C
0.183
2-tert-butyl-1,4-benzoquinone
-
at pH 7.4 and 37C
-
0.785
20alpha-hydroxy-5alpha-pregnan-3-one
-
+/-4.3
0.04 - 1.17
20alpha-hydroxyprogesterone
0.183
3-deoxyglucosone
-
at pH 7.4 and 37C
0.208
3alpha-hydroxy-pregnan-20-one
-
+/-1.6
0.043
4-androstene-3,17-dione
-
at pH 7.4 and 37C
0.068
4-chromanol
-
at pH 7.4 and 37C
0.009
4-hydroxy-2-nonenal
-
at pH 7.4 and 37C
0.112
4-Nitroacetophenone
-
at pH 7.4 and 37C
5.91
4-Nitrobenzaldehyde
-
+/-33.4
0.0115
4-oxo-2-hexenal
-
at pH 7.4 and 37C
-
0.112
4-oxo-2-nonenal
-
at pH 7.4 and 37C
0.032
4-pregnen-3alpha-ol-20-one
-
at pH 7.4 and 37C
-
0.1
5-androstene-3beta,17beta-diol
-
at pH 7.4 and 37C
0.27
5alpha-androstan-3alpha,17beta-diol
-
at pH 7.4 and 37C
0.085
5alpha-Androstan-3alpha-ol-17-one
-
at pH 7.4 and 37C
0.032
5alpha-androstan-3beta,17beta-diol
-
at pH 7.4 and 37C
0.083
5alpha-Androstan-3beta-ol-17-one
-
at pH 7.4 and 37C
0.025 - 0.047
5alpha-dihydrotestosterone
0.077 - 0.158
5alpha-pregnan-20alpha-ol-3-one
0.018
5alpha-pregnan-3,20-dione
-
at pH 7.4 and 37C
0.025
5alpha-pregnan-3alpha,20alpha-diol
-
at pH 7.4 and 37C
0.018
5alpha-Pregnan-3alpha,21-diol-20-one
-
at pH 7.4 and 37C
0.032
5alpha-pregnan-3alpha-ol-20-one
-
at pH 7.4 and 37C
0.153
5beta-androstan-17beta-ol-3-one
-
at pH 7.4 and 37C
0.25
5beta-Androstan-3alpha,17beta-diol
-
at pH 7.4 and 37C
0.067
5beta-Androstan-3alpha-ol-17-one
-
at pH 7.4 and 37C
0.033
5beta-Androstan-3beta,17beta-diol
-
at pH 7.4 and 37C
0.045
5beta-androstan-3beta-ol-17-one
-
at pH 7.4 and 37C
0.153
5beta-pregnan-20alpha-ol-3-one
-
at pH 7.4 and 37C
0.028
5beta-pregnan-3,20-dione
-
at pH 7.4 and 37C
0.283
5beta-pregnan-3alpha,20alpha-diol
-
at pH 7.4 and 37C
0.017
5beta-Pregnan-3alpha,21-diol-20-one
-
at pH 7.4 and 37C
0.03
5beta-Pregnan-3alpha-ol-20-one
-
at pH 7.4 and 37C
0.167
6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione
-
at pH 7.4 and 37C
-
0.043
7alpha-hydroxy-dehydroepiandrosterone
-
at pH 7.4 and 37C
7.7
9,10-phenanthrenequinone
-
+/-26.9
0.097
acetoin
-
at pH 7.4 and 37C
0.035
acrolein
-
at pH 7.4 and 37C
0.0085
all-trans-retinal
-
at pH 7.4 and 37C
0.053
alpha-tetralone
-
at pH 7.4 and 37C
0.117
befunolol
-
at pH 7.4 and 37C
0.233
beta-ionol
-
at pH 7.4 and 37C
-
0.215
D,L-glyceraldehyde
-
+/-0.3
0.155
dehydroepiandrosterone
-
at pH 7.4 and 37C
0.08
dehydroepiandrosterone 3-sulfate
-
at pH 7.4 and 37C
0.158
diacetyl
-
at pH 7.4 and 37C
0.017
estrone
-
at pH 7.4 and 37C
0.098
Estrone 3-sulfate
-
at pH 7.4 and 37C
0.033
geraniol
-
at pH 7.4 and 37C
0.043
Hexanal
-
at pH 7.4 and 37C
0.137
isatin
-
at pH 7.4 and 37C
0.023
isocaproaldehyde
-
at pH 7.4 and 37C
0.02
ketotifen
-
at pH 7.4 and 37C
0.125
menadione
-
at pH 7.4 and 37C
0.12
methylglyoxal
-
at pH 7.4 and 37C
1.52
NADP+
-
+/-6.1
1.43
NADPH
-
+/-1.3
0.032
Nonanal
-
at pH 7.4 and 37C
0.027 - 1.65
progesterone
0.132
pyridine 3-aldehyde
-
at pH 7.4 and 37C
0.057
testosterone
-
at pH 7.4 and 37C
0.025
trans-2-hexenal
-
at pH 7.4 and 37C
0.02
trans-2-nonenal
-
at pH 7.4 and 37C
0.108
trans-benzene dihydrodiol
-
at pH 7.4 and 37C