1.1.1.149: 20alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 20alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

17alpha,20alpha-dihydroxypregn-4-en-3-one
+
NAD(P)+
=
17alpha-hydroxyprogesterone
+
NAD(P)H
+
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20alpha-HSD, 20alpha-HSDH, 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxysteroid dehydrogenase, 20alpha-hydroxysteroid oxidoreductase, 20alpha-OH-SDH, AKR1C1, AKR1C23, AKR1C3, AKR1C5, aldo-keto reductase family 1 member C1, HSD1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.149 20alpha-hydroxysteroid dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.149 - 20alpha-hydroxysteroid dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-1-indanol + NADP+
?
show the reaction diagram
-
-
-
-
?
(S)-1-tetralol + NADP+
?
show the reaction diagram
-
-
-
-
?
(S)-tetralol + NAD(P)+
3,4-dihydronaphthalen-1(2H)-one + NAD(P)H + H+
show the reaction diagram
-
-
-
-
?
1-acenaphthenol + NAD+
? + NADH + H+
show the reaction diagram
-
-
-
-
?
1-phenyl-1,2-propanedione + NADPH
NADP+ + ?
show the reaction diagram
11-deoxycorticosterone + NAD(P)H
4-pregnen-20alpha,21-diol-3-one + NAD(P)+
show the reaction diagram
11-deoxycortisol + NADH
? + NAD+
show the reaction diagram
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
17alpha-hydroxyprogesterone + NAD(P)H
show the reaction diagram
17alpha,21-dihydroxyadrenocorticosteroid + NAD(P)H
? + NADP+
show the reaction diagram
-
NADH preferred
-
?
17alpha-hydroxycorticosterone + NADPH
? + NADP+
show the reaction diagram
-
less reactive than with 17alpha-hydroxyrogesterone
-
?
17alpha-hydroxypregnenolone + NADPH
? + NADP+
show the reaction diagram
17alpha-hydroxyprogesterone + NAD(P)H
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
show the reaction diagram
17alpha-hydroxyprogesterone + NAD(P)H + H+
17alpha,20alpha-dihydroxy-pregn-4-en-3-one + NAD(P)+
show the reaction diagram
17alpha-hydroxyprogesterone + NADPH
17alpha,20alpha-dihydroxyprogesterone + NADP+
show the reaction diagram
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20alpha-dihydroxy-pregn-4-en-3-one + NADP+
show the reaction diagram
17beta-estradiol + NADP+
?
show the reaction diagram
-
-
-
-
?
2,3-butanedione + NADPH
? + NADP+
show the reaction diagram
2,3-heptanedione + NADPH
NADP+ + ?
show the reaction diagram
2,3-hexanedione + NADPH
NADP+ + ?
show the reaction diagram
2,3-pentanedione + NADPH
NADP+ + ?
show the reaction diagram
2-tert-butyl-1,4-benzoquinone + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
20alpha-dihydroprogesterone + NAD+
progesterone + NADH
show the reaction diagram
-
-
-
?
20alpha-dihydroprogesterone + NADP+
progesterone + NADPH
show the reaction diagram
-
-
-
?
20alpha-hydroxy-5beta-pregnan-3-one + NADP+
5beta-pregnane-3,20-dione + NADPH
show the reaction diagram
-
-
-
?
20alpha-hydroxyprogesterone + NAD+
progesterone + NADH
show the reaction diagram
-
-
-
-
?
20alpha-hydroxyprogesterone + NADP+
?
show the reaction diagram
-
-
-
-
?
20alpha-hydroxyprogesterone + NADP+
progesterone + NADPH
show the reaction diagram
3-deoxyglucosone + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
4-androstene-3,17-dione + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
4-chromanol + NADP+
?
show the reaction diagram
-
-
-
-
?
4-hydroxy-2-nonenal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
4-nitroacetophenone + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
4-nitrobenzaldehyde + NADPH
4-nitrobenzyl alcohol + NADP+
show the reaction diagram
4-oxo-2-hexenal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
4-oxo-2-nonenal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
4-pregnen-20alpha-ol-3-one + NAD(P)+
4-pregnen-3,20-dione + NAD(P)H + H+
show the reaction diagram
-
-
-
-
r
4-pregnen-3alpha-ol-20-one + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
5-androstene-3beta,17beta-diol + NADP+
?
show the reaction diagram
-
-
-
-
?
5alpha-androstan-3alpha,17beta-diol + NADP+
?
show the reaction diagram
-
-
-
-
?
5alpha-androstan-3alpha-ol-17-one + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
5alpha-androstan-3beta,17beta-diol + NADP+
?
show the reaction diagram
-
-
-
-
?
5alpha-androstan-3beta-ol-17-one + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
5alpha-dihydrotestosterone + NADP+
?
show the reaction diagram
-
-
-
-
?
5alpha-dihydrotestosterone + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
5alpha-dihydrotestosterone + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
?
5alpha-pregnan-20alpha-ol-3-one + NAD(P)+
5alpha-pregnan-3,20-dione + NAD(P)H
show the reaction diagram
-
-
-
-
r
5alpha-pregnan-20alpha-ol-3-one + NAD(P)+
5alpha-pregnane-3,20-dione + NAD(P)H
show the reaction diagram
-
-
-
-
r
5alpha-pregnan-20alpha-ol-3-one + NADP+
5beta-pregnan-3,20-dione + NADPH + H+
show the reaction diagram
-
-
-
-
r
5alpha-pregnan-20alpha-ol-3-one + NADP+
?
show the reaction diagram
-
-
-
-
?
5alpha-pregnan-3,20-dione + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
5alpha-pregnan-3alpha,20alpha-diol + NADP+
?
show the reaction diagram
-
-
-
-
?
5alpha-pregnan-3alpha,21-diol-20-one + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
5alpha-pregnan-3alpha-ol-20-one + NAD(P)H
5alpha-pregnan-3alpha,20alpha-diol + NAD(P)+
show the reaction diagram
-
-
-
-
r
5alpha-pregnan-3alpha-ol-20-one + NAD(P)H + H+
5alpha-pregnan-3alpha,20alpha-diol + NAD(P)+
show the reaction diagram
-
-
-
-
r
5alpha-pregnan-3alpha-ol-20-one + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
5alpha-pregnane-21-ol-3,20-dione + NAD(P)H
5alpha-pregnane-20alpha,21-diol-3-one + NAD(P)+
show the reaction diagram
-
-
-
-
r
5alpha-pregnane-3,20-dione + NAD(P)H
5alpha-pregnan-20alpha-ol-3-one + NAD(P)+
show the reaction diagram
-
-
-
-
r
5alpha-pregnane-3alpha,20alpha-diol + NAD(P)+
3alpha-hydroxy-5alpha-pregnan-20-one + NAD(P)H + H+
show the reaction diagram
5alpha-pregnane-3alpha,21-diol-20-one + NAD(P)H + H+
5alpha-pregnane-3alpha,20alpha,21-triol + NAD(P)+
show the reaction diagram
-
-
-
-
r
5beta-androstan-17beta-ol-3-one + NADP+
?
show the reaction diagram
-
-
-
-
?
5beta-androstan-3alpha,17beta-diol + NADP+
?
show the reaction diagram
-
-
-
-
?
5beta-androstan-3alpha-ol-17-one + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
5beta-androstan-3beta,17beta-diol + NADP+
?
show the reaction diagram
-
-
-
-
?
5beta-androstan-3beta-ol-17-one + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
5beta-dihydrocortisol + NADH
? + NAD+
show the reaction diagram
-
-
-
r
5beta-pregnan-20alpha-ol-3-one + NAD(P)+
5beta-pregnan-3,20-dione + NAD(P)H
show the reaction diagram
-
-
-
-
r
5beta-pregnan-20alpha-ol-3-one + NADP+
?
show the reaction diagram
-
-
-
-
?
5beta-pregnan-3,20-dione + NADPH + H+
5alpha-pregnan-20alpha-ol-3-one + NADP+
show the reaction diagram
-
-
-
-
r
5beta-pregnan-3alpha,20alpha-diol + NADP+
?
show the reaction diagram
-
-
-
-
?
5beta-pregnan-3alpha,21-diol-20-one + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
5beta-pregnan-3alpha-ol-20-one + NAD(P)H
5beta-pregnan-3alpha,20alpha-diol + NAD(P)+
show the reaction diagram
-
-
-
-
r
5beta-pregnan-3alpha-ol-20-one + NAD(P)H
5beta-pregnane-3alpha,20alpha-diol + NAD(P)+
show the reaction diagram
-
-
-
-
r
5beta-pregnan-3alpha-ol-20-one + NAD(P)H + H+
5alpha-pregnan-3alpha,20alpha-diol + NAD(P)+
show the reaction diagram
-
-
-
-
?
5beta-pregnan-3alpha-ol-20-one + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
5beta-pregnane-3,20-dione + NAD(P)H + H+
5alpha-pregnan-20alpha-ol-3-one + NAD(P)+
show the reaction diagram
-
-
-
-
r
5beta-pregnane-3alpha,20alpha-diol + NAD(P)+
5beta-pregnan-20alpha-ol-3-one + NAD(P)H + H+
show the reaction diagram
6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
7alpha-hydroxy-dehydroepiandrosterone + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
NADP+ + ?
show the reaction diagram
-
-
-
-
-
acetoacetyl-CoA + NADPH
NADP+ + ?
show the reaction diagram
acetoin + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
acrolein + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
all-trans-retinal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
alpha-tetralone + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
befunolol + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
benzaldehyde + NADPH
benzyl alcohol + NADP+
show the reaction diagram
-
-
-
-
-
beta-ionol + NADP+
?
show the reaction diagram
-
-
-
-
?
corticosterone + NADPH
? + NADP+
show the reaction diagram
-
less reactive than with 17alpha-hydroxyprogesterone
-
?
cortisol + NADH
20alpha-dihydrocortisol + NAD+
show the reaction diagram
cortisone + NADH
? + NAD+
show the reaction diagram
D-galactose + NADPH
NADP+ + ?
show the reaction diagram
-
-
-
-
-
D-glucose + NADPH
NADP+ + ?
show the reaction diagram
-
-
-
-
-
daunorubicin + NADPH + H+
daunorubicinol + NADP+
show the reaction diagram
dehydroepiandrosterone + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
dehydroepiandrosterone 3-sulfate + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
diacetyl + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
dihydrotestosterone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
DL-glyceraldehyde + NADPH
glycerol + NADP+
show the reaction diagram
-
-
-
-
-
dydrogesterone + NADH + H+
20alpha-hydroxydydrogesterone + NAD+
show the reaction diagram
-
-
-
-
?
estrone + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
estrone 3-sulfate + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
ethyl 2-methylacetoacetate + NADPH
NADP+ + ?
show the reaction diagram
ethyl 4-chloroacetoacetate + NADPH
NADP+ + ?
show the reaction diagram
ethyl acetoaetate + NADPH
(S)-ethyl 3-hydroxybutyrate + NADP+
show the reaction diagram
ethyl pyruvate + NADPH
NADP+ + ?
show the reaction diagram
geraniol + NADP+
?
show the reaction diagram
-
-
-
-
?
hexanal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
isatin + NADP+
?
show the reaction diagram
-
-
-
-
?
isatin + NADPH
NADP+ + ?
show the reaction diagram
isocaproaldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
ketotifen + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
menadione + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
methylglyoxal + NADPH
NADP+ + ?
show the reaction diagram
methylglyoxal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
nonanal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
progesterone + NAD(P)+
20alpha-hydroxyprogesterone + NAD(P)H + H+
show the reaction diagram
-
-
-
?
progesterone + NAD(P)H
20alpha-hydroxypregn-4-en-3-one + NAD(P)+
show the reaction diagram
progesterone + NAD(P)H
20alpha-hydroxyprogesterone + NAD(P)+
show the reaction diagram
progesterone + NAD(P)H + H+
20alpha-hydroxyprogesterone + NAD(P)+
show the reaction diagram
progesterone + NADH
20alpha-hydroxyprogesterone + NAD+
show the reaction diagram
-
-
-
-
?
progesterone + NADH + H+
20alpha-hydroxyprogesterone + NAD+
show the reaction diagram
progesterone + NADPH
20alpha-hydroxyprogesterone + NADP+
show the reaction diagram
progesterone + NADPH + H+
20alpha-hydroxyprogesterone + NADP+
show the reaction diagram
-
-
-
-
?
prostaglandin E2 + NADPH
NADP+ + ?
show the reaction diagram
-
low activity
-
-
-
pyridine 3-aldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
pyridine-3-aldehyde + NADPH
NADP+ + ?
show the reaction diagram
testosterone + NADP+
?
show the reaction diagram
-
-
-
-
?
trans-2-hexenal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
trans-2-nonenal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
trans-benzene dihydrodiol + NADP+
?
show the reaction diagram
-
-
-
-
?
additional information
?
-