1.1.1.149: 20alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 20alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

17alpha,20alpha-dihydroxypregn-4-en-3-one
+
NAD(P)+
=
17alpha-hydroxyprogesterone
+
NAD(P)H
+
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20alpha-HSD, 20alpha-HSDH, 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxysteroid dehydrogenase, 20alpha-hydroxysteroid oxidoreductase, 20alpha-OH-SDH, AKR1C1, AKR1C23, AKR1C3, aldo-keto reductase family 1 member C1, HSD1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.149 20alpha-hydroxysteroid dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.149 - 20alpha-hydroxysteroid dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-tetralol + NAD(P)+
(S)-tetralone + NAD(P)H + H+
show the reaction diagram
-
-
-
-
?
1-acenaphthenol + NAD+
? + NADH + H+
show the reaction diagram
-
-
-
-
?
1-phenyl-1,2-propanedione + NADPH
NADP+ + ?
show the reaction diagram
11-deoxycorticosterone + NAD(P)H
4-pregnen-20alpha,21-diol-3-one + NAD(P)+
show the reaction diagram
11-deoxycortisol + NADH
? + NAD+
show the reaction diagram
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
17alpha-hydroxyprogesterone + NAD(P)H
show the reaction diagram
17alpha,21-dihydroxyadrenocorticosteroid + NAD(P)H
? + NADP+
show the reaction diagram
-
NADH preferred
-
?
17alpha-hydroxycorticosterone + NADPH
? + NADP+
show the reaction diagram
-
less reactive than with 17alpha-hydroxyrogesterone
-
?
17alpha-hydroxypregnenolone + NADPH
? + NADP+
show the reaction diagram
17alpha-hydroxyprogesterone + NAD(P)H
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
show the reaction diagram
17alpha-hydroxyprogesterone + NAD(P)H + H+
17alpha,20alpha-dihydroxy-pregn-4-en-3-one + NAD(P)+
show the reaction diagram
17alpha-hydroxyprogesterone + NADPH
17alpha,20alpha-dihydroxyprogesterone + NADP+
show the reaction diagram
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20alpha-dihydroxy-pregn-4-en-3-one + NADP+
show the reaction diagram
2,3-butanedione + NADPH
? + NADP+
show the reaction diagram
2,3-heptanedione + NADPH
NADP+ + ?
show the reaction diagram
2,3-hexanedione + NADPH
NADP+ + ?
show the reaction diagram
2,3-pentanedione + NADPH
NADP+ + ?
show the reaction diagram
20alpha-dihydroprogesterone + NAD+
progesterone + NADH
show the reaction diagram
-
-
-
?
20alpha-dihydroprogesterone + NADP+
progesterone + NADPH
show the reaction diagram
-
-
-
?
20alpha-hydroxy-5beta-pregnan-3-one + NADP+
5beta-pregnane-3,20-dione + NADPH
show the reaction diagram
-
-
-
?
20alpha-hydroxyprogesterone + NAD+
progesterone + NADH
show the reaction diagram
-
-
-
-
?
20alpha-hydroxyprogesterone + NADP+
progesterone + NADPH
show the reaction diagram
4-nitrobenzaldehyde + NADPH
4-nitrobenzyl alcohol + NADP+
show the reaction diagram
4-pregnen-20alpha-ol-3-one + NAD(P)+
4-pregnen-3,20-dione + NAD(P)H + H+
show the reaction diagram
-
-
-
-
r
5alpha-pregnan-20alpha-ol-3-one + NAD(P)+
5alpha-pregnan-3,20-dione + NAD(P)H
show the reaction diagram
-
-
-
-
r
5alpha-pregnan-20alpha-ol-3-one + NAD(P)+
5alpha-pregnane-3,20-dione + NAD(P)H
show the reaction diagram
-
-
-
-
r
5alpha-pregnan-3alpha-ol-20-one + NAD(P)H
5alpha-pregnan-3alpha,20alpha-diol + NAD(P)+
show the reaction diagram
-
-
-
-
r
5alpha-pregnan-3alpha-ol-20-one + NAD(P)H + H+
5alpha-pregnan-3alpha,20alpha-diol + NAD(P)+
show the reaction diagram
-
-
-
-
r
5alpha-pregnane-21-ol-3,20-dione + NAD(P)H
5alpha-pregnane-20alpha,21-diol-3-one + NAD(P)+
show the reaction diagram
-
-
-
-
r
5alpha-pregnane-3,20-dione + NAD(P)H
5alpha-pregnan-20alpha-ol-3-one + NAD(P)+
show the reaction diagram
-
-
-
-
r
5alpha-pregnane-3alpha,20alpha-diol + NAD(P)+
3alpha-hydroxy-5alpha-pregnan-20-one + NAD(P)H + H+
show the reaction diagram
5alpha-pregnane-3alpha,21-diol-20-one + NAD(P)H + H+
5alpha-pregnane-3alpha,20alpha,21-triol + NAD(P)+
show the reaction diagram
-
-
-
-
r
5beta-dihydrocortisol + NADH
? + NAD+
show the reaction diagram
-
-
-
r
5beta-pregnan-20alpha-ol-3-one + NAD(P)+
5beta-pregnan-3,20-dione + NAD(P)H
show the reaction diagram
-
-
-
-
r
5beta-pregnan-3alpha-ol-20-one + NAD(P)H
5beta-pregnan-3alpha,20alpha-diol + NAD(P)+
show the reaction diagram
-
-
-
-
r
5beta-pregnan-3alpha-ol-20-one + NAD(P)H
5beta-pregnane-3alpha,20alpha-diol + NAD(P)+
show the reaction diagram
-
-
-
-
r
5beta-pregnan-3alpha-ol-20-one + NAD(P)H + H+
5alpha-pregnan-3alpha,20alpha-diol + NAD(P)+
show the reaction diagram
-
-
-
-
?
5beta-pregnane-3,20-dione + NAD(P)H + H+
5alpha-pregnan-20alpha-ol-3-one + NAD(P)+
show the reaction diagram
-
-
-
-
r
5beta-pregnane-3alpha,20alpha-diol + NAD(P)+
5beta-pregnan-20alpha-ol-3-one + NAD(P)H + H+
show the reaction diagram
9,10-phenanthrenequinone + NADPH
NADP+ + ?
show the reaction diagram
-
-
-
-
-
acetoacetyl-CoA + NADPH
NADP+ + ?
show the reaction diagram
benzaldehyde + NADPH
benzyl alcohol + NADP+
show the reaction diagram
-
-
-
-
-
corticosterone + NADPH
? + NADP+
show the reaction diagram
-
less reactive than with 17alpha-hydroxyprogesterone
-
?
cortisol + NADH
20alpha-dihydrocortisol + NAD+
show the reaction diagram
cortisone + NADH
? + NAD+
show the reaction diagram
D-galactose + NADPH
NADP+ + ?
show the reaction diagram
-
-
-
-
-
D-glucose + NADPH
NADP+ + ?
show the reaction diagram
-
-
-
-
-
dihydrotestosterone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
DL-glyceraldehyde + NADPH
glycerol + NADP+
show the reaction diagram
-
-
-
-
-
dydrogesterone + NADH + H+
20alpha-hydroxydydrogesterone + NAD+
show the reaction diagram
-
-
-
-
?
ethyl 2-methylacetoacetate + NADPH
NADP+ + ?
show the reaction diagram
ethyl 4-chloroacetoacetate + NADPH
NADP+ + ?
show the reaction diagram
ethyl acetoaetate + NADPH
(S)-ethyl 3-hydroxybutyrate + NADP+
show the reaction diagram
ethyl pyruvate + NADPH
NADP+ + ?
show the reaction diagram
isatin + NADPH
NADP+ + ?
show the reaction diagram
methylglyoxal + NADPH
NADP+ + ?
show the reaction diagram
progesterone + NAD(P)+
20alpha-hydroxyprogesterone + NAD(P)H + H+
show the reaction diagram
-
-
-
?
progesterone + NAD(P)H
20alpha-hydroxypregn-4-en-3-one + NAD(P)+
show the reaction diagram
progesterone + NAD(P)H
20alpha-hydroxyprogesterone + NAD(P)+
show the reaction diagram
progesterone + NAD(P)H + H+
20alpha-hydroxyprogesterone + NAD(P)+
show the reaction diagram
progesterone + NADH
20alpha-hydroxyprogesterone + NAD+
show the reaction diagram
-
-
-
-
?
progesterone + NADPH
20alpha-hydroxyprogesterone + NADP+
show the reaction diagram
prostaglandin E2 + NADPH
NADP+ + ?
show the reaction diagram
-
low activity
-
-
-
pyridine-3-aldehyde + NADPH
NADP+ + ?
show the reaction diagram
additional information
?
-