1.1.1.149: 20alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 20alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

17alpha,20alpha-dihydroxypregn-4-en-3-one
+
NAD(P)+
=
17alpha-hydroxyprogesterone
+
NAD(P)H
+
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20alpha-HSD, 20alpha-HSDH, 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxysteroid dehydrogenase, 20alpha-hydroxysteroid oxidoreductase, 20alpha-OH-SDH, AKR1C1, AKR1C23, AKR1C3, aldo-keto reductase family 1 member C1, HSD1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.149 20alpha-hydroxysteroid dehydrogenase

Specific Activity

Specific Activity on EC 1.1.1.149 - 20alpha-hydroxysteroid dehydrogenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.002
-
reduction of 0.06 mM prostaglandin E2
0.007
-
reduction of 0.03 mM 17alpha-hydroxy-pregnenolone
0.012
-
+/-0.005
0.013
-
reduction of 100 mM D-glucose
0.016
-
reduction of 0.03 mM prednisolone
0.017
-
reduction of 100 mM D-galactose
0.024
-
+/-0.006
0.025
-
reduction of 0.03 mM prednisone
0.038 - 0.046
-
calculated from 17beta-estadiol dehydrogenase activity
0.067
-
reduction of 0.05 mM pregnenolone
0.081
-
-
0.115
-
-
0.2596
-
insect cells
0.2769
-
HSD2, reduction of 17alpha-hydroxyprogesterone
0.282
-
measured with cortisone
0.332
-
+/-0.047, Escherichia coli
0.9
-
reduction of 0.06 mM 5alpha-pregnane-3,20-dione
1.3
-
pH 6.5, temperature not specified in the publication
1.462
-
HSD1, reduction of 17alpha-hydroxyprogesterone
2.09
-
20alpha-hydroxyprogesterone
2.5
-
oxidation of 0.06 mM 20alpha-hydroxy-5beta-pregnan-3-one
3.815
-
HSD2, reduction of progesterone
4.618
-
HSD1
6.515
-
HSD2
8.154
-
HSD1, reduction of progesterone
additional information