1.1.1.149: 20alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 20alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

17alpha,20alpha-dihydroxypregn-4-en-3-one
+
NAD(P)+
=
17alpha-hydroxyprogesterone
+
NAD(P)H
+
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20alpha-HSD, 20alpha-HSDH, 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxysteroid dehydrogenase, 20alpha-hydroxysteroid oxidoreductase, 20alpha-OH-SDH, AKR1C1, AKR1C23, AKR1C3, aldo-keto reductase family 1 member C1, HSD1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.149 20alpha-hydroxysteroid dehydrogenase

Source Tissue

Source Tissue on EC 1.1.1.149 - 20alpha-hydroxysteroid dehydrogenase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
abdominal subcutaneous and omental adipose tissue, the enzyme activity is highest in women with visceral obesity, expression analysis
Manually annotated by BRENDA team
-
high expression level
Manually annotated by BRENDA team
-
breast cancer cells: tumorgenic strains MCF-7, MDA-MB-231, T-47D, nontumorgenic strain MCF-10A
Manually annotated by BRENDA team
placental cytotrophoblast villus
Manually annotated by BRENDA team
-
fetal
Manually annotated by BRENDA team
-
20alpha-HSD mRNA highly expressed
Manually annotated by BRENDA team
endometrial glandular epithelial cell
Manually annotated by BRENDA team
moderate expression rate of AKR1C23
Manually annotated by BRENDA team
preovulatory, very high expression rate, expression analysis of AKR1C23, activity during follicular luteinization, overview
Manually annotated by BRENDA team
-
20alpha-HSD mRNA lower expressed
Manually annotated by BRENDA team
moderate expression rate of AKR1C23
Manually annotated by BRENDA team
very low expression rate of AKR1C23
Manually annotated by BRENDA team
low expression rate of AKR1C23
Manually annotated by BRENDA team
placental cytotrophoblast villus
Manually annotated by BRENDA team
additional information
-
unfixed tissue section, soluble, retention by PVA
Manually annotated by BRENDA team