1.1.1.149: 20alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 20alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

17alpha,20alpha-dihydroxypregn-4-en-3-one
+
NAD(P)+
=
17alpha-hydroxyprogesterone
+
NAD(P)H
+
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20alpha-HSD, 20alpha-HSDH, 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxysteroid dehydrogenase, 20alpha-hydroxysteroid oxidoreductase, 20alpha-OH-SDH, AKR1C1, AKR1C23, AKR1C3, aldo-keto reductase family 1 member C1, HSD1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.149 20alpha-hydroxysteroid dehydrogenase

KM Value

KM Value on EC 1.1.1.149 - 20alpha-hydroxysteroid dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1 - 1870
(S)-ethyl 3-hydroxybutyrate
4.8 - 5
(S)-methyl 3-hydroxybutyrate
0.007 - 0.47
(S)-tetralol
0.092 - 0.129
1,2-Cyclohexanedione
0.006
1-phenyl-1,2-propanedione
0.0033
11-deoxycorticosterone
-
pH 7.4, 37C
0.073
17-hydroxyprogesterone
-
-
0.013
17alpha,20alpha-dihydroxypregn-4-en-3-one
-
-
0.013 - 0.014
17alpha,20alpha-dihydroxyprogesterone
0.022
17alpha,21-dihydroxy-5beta-pregnan-3,20-dione
-
-
0.02
17alpha,21-dihydroxy-5beta-pregnane-3,11,20-trione
-
-
0.002 - 0.0034
17alpha-hydroxypregnenolone
0.0029 - 0.118
17alpha-hydroxyprogesterone
34.8 - 66.3
2,3-Butanediol
0.015 - 0.018
2,3-Butanedione
0.005 - 0.008
2,3-heptanedione
0.01 - 0.016
2,3-Hexanedione
0.018 - 0.021
2,3-Pentanedione
0.131 - 0.243
2,4-Pentanedione
0.0026
2-amino-8-((2-fluoro-4-methoxybenzyl)thio)-1,9-dihydro-6H-purin-6-one
-
pH 7.0, 25C
0.041
20alpha-dihydrocortisol
-
NAD+, pH 7.9
0.00102 - 0.00516
20alpha-hydroxy-4-pregnen-3-one
0.013
20alpha-hydroxy-5alpha-pregnan-3-one
-
+/-0.0035
0.073
20alpha-hydroxy-5beta-pregnan-3-one
-
-
0.00117 - 2.5
20alpha-hydroxyprogesterone
0.23 - 0.57
3,4-hexanedione
0.00208
3-acetylpyridine adenine dinucleotide phosphate
-
NADP analog
0.012
3alpha-hydroxy-5alpha-pregnan-20-one
-
+/-0.0035
0.221 - 0.3811
4-Nitrobenzaldehyde
0.016
4-pregnen-20alpha-ol-3-one
-
pH 7.0, 25C
0.0007 - 0.0027
5alpha-pregnan-20alpha-ol-3-one
0.002 - 0.0033
5alpha-pregnan-3alpha-ol-20-one
0.0012
5alpha-pregnane-21-ol-3,20-dione
-
pH 7.0, 25C
0.0011
5alpha-pregnane-3,20-dione
-
pH 7.0, 25C
0.0004 - 0.0009
5alpha-pregnane-3alpha,20alpha-diol
0.001 - 0.073
5beta-pregnan-20alpha-ol-3-one
0.0033 - 0.0062
5beta-Pregnan-3alpha-ol-20-one
0.0012
5beta-pregnane-3,20-dione
-
pH 7.0, 25C
0.0015
5beta-pregnane-3alpha,20alpha-diol
-
pH 7.0, 25C
0.00195
9,10-phenanthrenequinone
-
+/-0.0004
0.02 - 0.022
acetoacetyl-CoA
0.186 - 0.272
acetoin
2.1
benzene dihydrodiol
-
-
0.008
benzyl acetoacetate
0.078
Camphorquinone
-
-
2.02 - 2.9
cis-benzene-1,2-dihydrodiol
0.032
cortisol
-
NADH, pH 6.3
0.022
cortisone
-
NADH, pH 6.3
120
D,L-glyceraldehyde
-
-
0.3 - 0.67
D-glyceraldehyde
0.534 - 0.587
D-Lactaldehyde
0.069 - 0.151
dihydrotestosterone
0.852 - 1.3
DL-glyceraldehyde-3-phosphate
0.012 - 0.015
ethyl 2-methylacetoacetate
0.222 - 0.447
ethyl 3-oxovalerate
0.027
ethyl 4-chloroacetoacetate
0.02 - 20
ethyl acetoacetate
0.303 - 0.654
ethyl benzoylacetate
0.025
ethyl pyruvate
0.039 - 0.064
isatin
0.117 - 0.123
methyl acetoacetate
0.356 - 0.548
methylglyoxal
0.004
n-butyl acetoacetate
0.0015 - 0.0024
n-hexyl acetoacetate
0.0013 - 0.0016
n-octyl acetoacetate
0.526
NAD+
-
20alpha-dihydrocortisol
0.0081 - 1.1
NADH
0.0007 - 0.025
NADP+
0.0002 - 0.052
NADPH
0.1429
nicotinamide 1,N6-ethenoadenine dinucleotide phosphate
-
NADP analog
0.0588
nicotinamide hypoxanthine dinucleotide phosphate
-
NADP analog
0.43 - 0.591
Phenylglyoxal
0.0006 - 0.2833
progesterone
0.049 - 0.081
Pyridine-3-aldehyde
0.945 - 1.06
Pyridine-4-aldehyde
0.00186
thionicotinamide adenine dinucleotide phosphate
-
NADP analog
50.9 - 79.7
trans-1S,2S-cyclohexanediol
1.6
trans-benzene-1S,2S-dihydrodiol
additional information
additional information
-