1.1.1.149: 20alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 20alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

17alpha,20alpha-dihydroxypregn-4-en-3-one
+
NAD(P)+
=
17alpha-hydroxyprogesterone
+
NAD(P)H
+
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20alpha-HSD, 20alpha-HSDH, 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxysteroid dehydrogenase, 20alpha-hydroxysteroid oxidoreductase, 20alpha-OH-SDH, AKR1C1, AKR1C23, AKR1C3, aldo-keto reductase family 1 member C1, HSD1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.149 20alpha-hydroxysteroid dehydrogenase

KI Value

KI Value on EC 1.1.1.149 - 20alpha-hydroxysteroid dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0358
1-phenylcyclopentanecarboxylic acid
-
pH 6.5, temperature not specified in the publication
0.00134
2',5'-adenosine bisphosphate
-
pH 7.8, 23C
0.148
2'-adenylic acid
-
pH 7.8, 23C
0.0172
2-(4-chlorobenzylidene)cyclopentanone
-
pH 6.5, temperature not specified in the publication
0.0305
2-(4-chlorobenzylidene)cyclopentyl ethyl ether
-
pH 6.5, temperature not specified in the publication
0.0000007
3',3'',5',5''-tetrabromophenolphthalein
-
binding to NADPH-enzyme complex via ordered bi-bi-mechanism
0.000009
3,5-dibromosalicylic acid
-
-
0.0000059 - 0.0028
3,5-dichlorosalicylic acid
0.000009
3,5-diiodosalicylic acid
-
-
0.000004 - 0.000113
3-bromo-5-phenylsalicylic acid
0.00000085 - 0.00007
3-chloro-5-phenylsalicylic acid
0.00014
3-phenyl-5-bromosalicylic acid
-
-
0.0485
3-phenylcyclopentanecarboxylic acid
-
pH 6.5, temperature not specified in the publication
0.0000021
4'-butyl-5-chloro-4-hydroxybiphenyl-3-carboxylic acid
-
wild-type, 25C, pH not specified in the publication
2.84
5'-adenylic acid
-
pH 7.8, 23C
0.0000013
5-chloro-4-hydroxy-3'-methylbiphenyl-3-carboxylic acid
-
wild-type, 25C, pH not specified in the publication
0.0000026
5-chloro-4-hydroxy-4'-methylbiphenyl-3-carboxylic acid
-
wild-type, 25C, pH not specified in the publication
0.00000086
5-chloro-4-hydroxybiphenyl-3-carboxylic acid
-
wild-type, 25C, pH not specified in the publication
0.0000013
5-fluoro-4-hydroxybiphenyl-3-carboxylic acid
-
wild-type, 25C, pH not specified in the publication
0.021
Acetylsalicylate
-
-
0.00087
adenosine 2'-monophospho- 5'-diphosphoribose
-
pH 7.8, 23C
0.95
adenosine diphosphoribose
-
pH 7.8, 23C
0.34
ADP
-
pH 7.8, 23C
0.01
aminopyridine 1,N6-ethenoadenine dinucleotide phosphate
-
pH 7.8, 23C
0.0029
aminopyridine adenine dinucleotide phosphate
-
pH 7.8, 23C
0.022
Diazotized 3-aminopyridine 1,N6-ethenoadenine dinucleotide phosphate
-
pH 7.8, 23C
0.0005
Diazotized 3-aminopyridine adenine dinucleotide phosphate
-
pH 7.8, 23C
9.29
N-1-butylnicotinamide chloride
-
pH 7.8, 23C
1.24
N-1-decylnicotinamide chloride
-
pH 7.8, 23C
8.95
N-1-ethylnicotinamide chloride
-
pH 7.8, 23C
3.39
N-1-heptylnicotinamide chloride
-
pH 7.8, 23C
6.59
N-1-hexylnicotinamide chloride
-
pH 7.8, 23C
0.205 - 14.8
N-1-methylnicotinamide chloride
3.29
N-1-nonylnicotinamide chloride
-
pH 7.8, 23C
4.01
N-1-octylnicotinamide chloride
-
pH 7.8, 23C
9.35
N-1-pentylnicotinamide chloride
-
pH 7.8, 23C
8.24
N-1-propylnicotinamide chloride
-
pH 7.8, 23C
0.487
N-1-undecylnicotinamide chloride
-
pH 7.8, 23C
0.00074
NADP+
-
pH 7.8, 23C
0.0078
salicylate
-
-
additional information
additional information
-