1.1.1.149: 20alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 20alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

17alpha,20alpha-dihydroxypregn-4-en-3-one
+
NAD(P)+
=
17alpha-hydroxyprogesterone
+
NAD(P)H
+
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20alpha-HSD, 20alpha-HSDH, 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxysteroid dehydrogenase, 20alpha-hydroxysteroid oxidoreductase, 20alpha-OH-SDH, AKR1C1, AKR1C23, AKR1C3, AKR1C5, aldo-keto reductase family 1 member C1, HSD1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.149 20alpha-hydroxysteroid dehydrogenase

KCat KM Value

KCat KM Value on EC 1.1.1.149 - 20alpha-hydroxysteroid dehydrogenase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.5
(S)-1-indanol
-
at pH 7.4 and 37°C
2
(S)-1-tetralol
-
at pH 7.4 and 37°C
0.0000008 - 0.000062
(S)-tetralol
8.7
17beta-estradiol
-
at pH 7.4 and 37°C
183.3
2-tert-butyl-1,4-benzoquinone
-
at pH 7.4 and 37°C
-
21.7
20alpha-hydroxyprogesterone
-
at pH 7.4 and 37°C
0.13
3-deoxyglucosone
-
at pH 7.4 and 37°C
43.3
4-androstene-3,17-dione
-
at pH 7.4 and 37°C
0.45
4-chromanol
-
at pH 7.4 and 37°C
1.6
4-hydroxy-2-nonenal
-
at pH 7.4 and 37°C
93.3
4-Nitroacetophenone
-
at pH 7.4 and 37°C
1.8
4-oxo-2-hexenal
-
at pH 7.4 and 37°C
-
0.062
4-oxo-2-nonenal
-
at pH 7.4 and 37°C
31.7
4-pregnen-3alpha-ol-20-one
-
at pH 7.4 and 37°C
-
31.7
5-androstene-3beta,17beta-diol
-
at pH 7.4 and 37°C
63.3
5alpha-androstan-3alpha,17beta-diol
-
at pH 7.4 and 37°C
20
5alpha-Androstan-3alpha-ol-17-one
-
at pH 7.4 and 37°C
14.3
5alpha-androstan-3beta,17beta-diol
-
at pH 7.4 and 37°C
13.8
5alpha-Androstan-3beta-ol-17-one
-
at pH 7.4 and 37°C
2.7 - 7.3
5alpha-dihydrotestosterone
1.3 - 14.3
5alpha-pregnan-20alpha-ol-3-one
36.7
5alpha-pregnan-3,20-dione
-
at pH 7.4 and 37°C
30
5alpha-pregnan-3alpha,20alpha-diol
-
at pH 7.4 and 37°C
3
5alpha-Pregnan-3alpha,21-diol-20-one
-
at pH 7.4 and 37°C
25
5alpha-pregnan-3alpha-ol-20-one
-
at pH 7.4 and 37°C
0.00004 - 0.00027
5alpha-pregnane-3alpha,20alpha-diol
25
5beta-androstan-17beta-ol-3-one
-
at pH 7.4 and 37°C
183.3
5beta-Androstan-3alpha,17beta-diol
-
at pH 7.4 and 37°C
40
5beta-Androstan-3alpha-ol-17-one
-
at pH 7.4 and 37°C
13.3
5beta-Androstan-3beta,17beta-diol
-
at pH 7.4 and 37°C
16
5beta-androstan-3beta-ol-17-one
-
at pH 7.4 and 37°C
26.7
5beta-pregnan-20alpha-ol-3-one
-
at pH 7.4 and 37°C
28.3
5beta-pregnan-3,20-dione
-
at pH 7.4 and 37°C
36.7
5beta-pregnan-3alpha,20alpha-diol
-
at pH 7.4 and 37°C
6.3
5beta-Pregnan-3alpha,21-diol-20-one
-
at pH 7.4 and 37°C
0.0000007 - 30
5beta-Pregnan-3alpha-ol-20-one
83.3
6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione
-
at pH 7.4 and 37°C
-
15
7alpha-hydroxy-dehydroepiandrosterone
-
at pH 7.4 and 37°C
1.3
acetoin
-
at pH 7.4 and 37°C
2.5
acrolein
-
at pH 7.4 and 37°C
0.95
all-trans-retinal
-
at pH 7.4 and 37°C
1
alpha-tetralone
-
at pH 7.4 and 37°C
13.2
befunolol
-
at pH 7.4 and 37°C
10.1
beta-ionol
-
at pH 7.4 and 37°C
-
26.7
dehydroepiandrosterone
-
at pH 7.4 and 37°C
18.3
dehydroepiandrosterone 3-sulfate
-
at pH 7.4 and 37°C
8.3
diacetyl
-
at pH 7.4 and 37°C
15.1
estrone
-
at pH 7.4 and 37°C
14.7
Estrone 3-sulfate
-
at pH 7.4 and 37°C
0.018
geraniol
-
at pH 7.4 and 37°C
5.7
Hexanal
-
at pH 7.4 and 37°C
233.3
isatin
-
at pH 7.4 and 37°C
0.35
isocaproaldehyde
-
at pH 7.4 and 37°C
0.18
ketotifen
-
at pH 7.4 and 37°C
2
menadione
-
at pH 7.4 and 37°C
1.4
methylglyoxal
-
at pH 7.4 and 37°C
35
Nonanal
-
at pH 7.4 and 37°C
45
progesterone
-
at pH 7.4 and 37°C
2.2
pyridine 3-aldehyde
-
at pH 7.4 and 37°C
4.3
testosterone
-
at pH 7.4 and 37°C
3.3
trans-2-hexenal
-
at pH 7.4 and 37°C
3.7
trans-2-nonenal
-
at pH 7.4 and 37°C
0.42
trans-benzene dihydrodiol
-
at pH 7.4 and 37°C