1.1.1.149: 20alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 20alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

17alpha,20alpha-dihydroxypregn-4-en-3-one
+
NAD(P)+
=
17alpha-hydroxyprogesterone
+
NAD(P)H
+
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20alpha-HSD, 20alpha-HSDH, 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxysteroid dehydrogenase, 20alpha-hydroxysteroid oxidoreductase, 20alpha-OH-SDH, AKR1C1, AKR1C23, AKR1C3, AKR1C5, aldo-keto reductase family 1 member C1, HSD1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.149 20alpha-hydroxysteroid dehydrogenase

IC50 Value

IC50 Value on EC 1.1.1.149 - 20alpha-hydroxysteroid dehydrogenase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0729
1-phenylcyclopentanecarboxylic acid
Homo sapiens
-
pH 6.5, temperature not specified in the publication
0.035
2-(4-chlorobenzylidene)cyclopentanone
Homo sapiens
-
pH 6.5, temperature not specified in the publication
0.0621
2-(4-chlorobenzylidene)cyclopentyl ethyl ether
Homo sapiens
-
pH 6.5, temperature not specified in the publication
0.003
3',3'',5',5''-tetrabromophenolphthalein
Oryctolagus cuniculus
-
at pH 7.4 and 37°C
0.0986
3-phenylcyclopentanecarboxylic acid
Homo sapiens
-
pH 6.5, temperature not specified in the publication
0.00012
benzbromarone
Oryctolagus cuniculus
-
at pH 7.4 and 37°C
0.026
Flufenamic acid
Oryctolagus cuniculus
-
at pH 7.4 and 37°C
0.00041
galangin
Oryctolagus cuniculus
-
at pH 7.4 and 37°C
0.0064
Hexestrol
Oryctolagus cuniculus
-
at pH 7.4 and 37°C
0.00011
kaempferol
Oryctolagus cuniculus
-
at pH 7.4 and 37°C
0.01
Mefenamic acid
Oryctolagus cuniculus
-
at pH 7.4 and 37°C
0.00064
myricetin
Oryctolagus cuniculus
-
at pH 7.4 and 37°C
0.00037
naringenin
Oryctolagus cuniculus
-
at pH 7.4 and 37°C
0.000022
Phenolphthalein
Oryctolagus cuniculus
-
at pH 7.4 and 37°C
0.000059
quercetin
Oryctolagus cuniculus
-
at pH 7.4 and 37°C
0.011
Sulfobromophthalein
Oryctolagus cuniculus
-
at pH 7.4 and 37°C