1.1.1.149: 20alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 20alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

17alpha,20alpha-dihydroxypregn-4-en-3-one
+
NAD(P)+
=
17alpha-hydroxyprogesterone
+
NAD(P)H
+
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20alpha-HSD, 20alpha-HSDH, 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxysteroid dehydrogenase, 20alpha-hydroxysteroid oxidoreductase, 20alpha-OH-SDH, AKR1C1, AKR1C23, AKR1C3, aldo-keto reductase family 1 member C1, HSD1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.149 20alpha-hydroxysteroid dehydrogenase

Expression

Expression on EC 1.1.1.149 - 20alpha-hydroxysteroid dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
20alpha-HSD mRNA is higher expressed in the ovary at pre-ovulation than in the placenta and oviduct at pre-parturition
-
human immunodeficiency virus-infected pregnant women receiving protease inhibitor-based combination antiretroviral therapy show an elevation in placental expression of the 20-alpha-hydroxysteroid dehydrogenase
-
mRNA levels increase gradually throughout the estrous cycle, the highest being in the corpus luteum (CL) 1 stage
-
the amount of enzyme mRNA in cultured luteal cells increases with time and by treatment with the luteolysis agent prostaglandin F2alpha