1.1.1.149: 20alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 20alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

17alpha,20alpha-dihydroxypregn-4-en-3-one
+
NAD(P)+
=
17alpha-hydroxyprogesterone
+
NAD(P)H
+
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20alpha-HSD, 20alpha-HSDH, 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxysteroid dehydrogenase, 20alpha-hydroxysteroid oxidoreductase, 20alpha-OH-SDH, AKR1C1, AKR1C23, AKR1C3, aldo-keto reductase family 1 member C1, HSD1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.149 20alpha-hydroxysteroid dehydrogenase

Cloned

Cloned on EC 1.1.1.149 - 20alpha-hydroxysteroid dehydrogenase

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
cDNA of skin fibroblast cDNA library inserted into pCMV expression vector, transiently transfected into and expressed in HEK-293 cells
-
DNA and amino acid sequence determination and analysis, expression analysis of AKR1C23 in preovulatory follicles, overexpression in HEK-293 cells
expressed in Escherichia coli as a His-tagged fusion protein
-
expressed in Escherichia coli C41 (DE3)
-
expressed in Escherichia coli cells
-
expressed in Escherichia coli DH5alpha and baculovirus-insect cell systems Sf9
-
expressed in Escherichia coli JM109 cells
-
expressed in fission yeast Schizosaccharomyces pombe
-
expression in Escherichia coli
-
expression of soluble, active enzyme as GST-fusion enzyme in Escherichia coli
recombinantly expressed in Escherichia coli cells and CHO cells
-
recombinantly expressed in fission yeast cells
-
subcloned, overexpressed in Escherichia coli DH5alpha or C41 (DE3)
-