1.1.1.145: 3beta-hydroxy-DELTA5-steroid dehydrogenase

This is an abbreviated version, for detailed information about 3beta-hydroxy-DELTA5-steroid dehydrogenase, go to the full flat file.

Reaction

a 3beta-hydroxy-DELTA5-steroid
+
NAD+
=
a 3-oxo-DELTA5-steroid
+
NADH
+
H+

Synonyms

3-beta-hydroxy-5-ene steroid dehydrogenase, 3-beta-hydroxy-delta(5)-steroid dehydrogenase, 3beta hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-HSD type II, 3beta-HSD1, 3beta-HSD2, 3beta-HSD22, 3beta-HSDH, 3beta-HSD_1, 3beta-hydroxy steroid dehydrogenase/5-ene-4-ene isomerase, 3beta-hydroxy steroid dehydrogenase/isomerase, 3beta-hydroxy-5-ene steroid dehydrogenase, 3beta-hydroxy-5-ene-steroid dehydrogenase, 3beta-hydroxy-5-ene-steroid oxidoreductase, 3beta-hydroxy-DELTA5-C27-steroid dehydrogenase/isomerase, 3beta-hydroxy-DELTA5-C27-steroid oxidoreductase, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase 1, 3beta-hydroxysteroid dehydrogenase type 1, 3beta-hydroxysteroid dehydrogenase type 2, 3beta-hydroxysteroid dehydrogenase type II, 3beta-hydroxysteroid dehydrogenase type1, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELAT4 isomerase type 2, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase type II, 3beta-hydroxysteroid dehydrogenase/isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase type 1, 3betaHSD, 3betaHSD1, 3betaHSD2, 5-ene-3-beta-hydroxysteroid dehydrogenase, 5alpha-dihydrotestosterone 3beta-hydroxysteroid dehydrogenase, dehydrogenase, 3beta-hydroxy-DELTA5-steroid, DELTA5-3beta-hydroxysteroid dehydrogenase, DHRS4, HSD3B, HSD3B2, HSDB1, More, progesterone reductase, steroid-DELTA5-3beta-ol dehydrogenase, type 1 3beta-hydroxysteroid dehydrogenase, type 1 3beta-hydroxysteroid dehydrogenase/isomerase, type 2 3beta-hydroxysteroid dehydrogenase, type 2 3beta-hydroxysteroid dehydrogenase/isomerase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.145 - 3beta-hydroxy-DELTA5-steroid dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-1-indanol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
r
(S)-1-tetralol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
r
(S)-phenyl-1-butanol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
r
1,4-naphthoquinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
1-phenylisatin + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
11beta,17alpha,21-trihydroxy-4-pregnen-3,20-dione + NADPH
3beta,11beta,17alpha,21-tetrahydroxy-4-pregnen-20-one + NADP+
show the reaction diagram
-
-
-
-
?
11beta,17alpha,21-trihydroxy-5alpha-pregnane-3,20-dione + NADPH
3beta,11beta,17alpha,21-tetrahydroxy-5alpha-pregnan-20-one + NADP+
show the reaction diagram
-
-
-
-
?
11beta,17alpha,21-trihydroxy-5beta-pregnane-3,20-dione + NADPH
3beta,11beta,17alpha,21-tetrahydroxy-5beta-pregnan-20-one + NADP+
show the reaction diagram
-
-
-
-
?
13,14-dihydro-15-keto-prostaglandin F2 + NADPH
?
show the reaction diagram
-
-
-
-
?
13,14-dihydro-15-keto-prostaglandin F2alpha + NADPH
?
show the reaction diagram
-
-
-
-
?
16alpha-hydroxy-dehydroepiandrosterone + NAD+
?
show the reaction diagram
-
-
-
-
?
16alpha-hydroxy-dehydroepiandrosterone + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
16beta-hydroxy-dehydroepiandrosterone + NAD+
?
show the reaction diagram
-
-
-
-
?
16beta-hydroxy-dehydroepiandrosterone + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
17-hydroxyprogesterone + NADPH
3beta,17-dihydroxy-4-pregnen-20-one + NADP+
show the reaction diagram
-
-
-
-
?
17alpha-hydroxypregnenolone + NAD+
17alpha-hydroxy-pregn-5-en-3,20-dione + NADH
show the reaction diagram
-
-
-
?
17beta-hydroxy-5alpha-androstane-3-one + NADPH
3beta,17beta-dihydroxy-5alpha-androstane + NADP+
show the reaction diagram
-
-
-
-
?
17beta-hydroxy-5beta-androstane-3-one + NADPH
3beta,17beta-dihydroxy-5beta-androstane + NADP+
show the reaction diagram
-
-
-
-
?
2,3-heptanedione + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
2,3-hexanedione + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
2,3-pentanedione + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
r
3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
show the reaction diagram
3beta,7alpha-dihydroxy-5-cholestenoic acid + NAD+
7alpha-hydroxy-3-oxo-5-cholestenoic acid + NADH
show the reaction diagram
-
-
-
-
?
3beta-hydroxy-5-androsten-17-one + NAD+
androstendione + NADH + H+
show the reaction diagram
3beta-hydroxyandrostan-17-one + NAD+
androstan-3,17-dione + NADH
show the reaction diagram
-
-
-
-
?
4,4'-dimethylbenzil + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
4-androsten-17beta-ol-3-one + NADH + H+
4-androsten-3beta,17beta-diol + NAD+
show the reaction diagram
-
-
-
r
4-androsten-3beta,17beta-diol + NAD+
4-androsten-17beta-ol-3-one + NADH
show the reaction diagram
-
-
-
-
?
4-benzoylpyridine + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
4-benzylpyridine + NADPH
?
show the reaction diagram
-
-
-
-
?
4-carboxybenzaldehyde + NADP+ + H2O
4-carboxybenzoic acid + NADPH + H+
show the reaction diagram
-
-
-
-
?
4-hexanoylpyridine + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
4-nitroacetophenone + NADPH
1-(4-nitrophenyl)ethanol + NADP+
show the reaction diagram
-
-
-
-
?
4-nitrobenzaldehyde + NADPH
4-nitrobenzyl alcohol + NADP+
show the reaction diagram
-
-
-
-
?
4-nitrobenzaldehyde + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
5,16-androstadien-3beta-ol + NAD+
5,16-androstadien-3-one + NADH
show the reaction diagram
-
-
-
-
?
5-androsten-3beta-ol-17-one + NAD+
5-androsten-3,17-dione + NADH
show the reaction diagram
-
-
-
r
5-pregnen-3beta-ol-2-one + NAD+
progesterone + NADH
show the reaction diagram
5alpha-androstan-3beta-ol-17-one + NADP+
5alpha-androstan-3,17-dione + NADPH
show the reaction diagram
5alpha-androstane-3,17-dione + NADPH
3beta-hydroxy-5alpha-androstane-17-one + NADP+
show the reaction diagram
-
-
-
-
?
5alpha-androstane-3,17-dione + NADPH
5alpha-androstane-3beta-ol-17-one + NADP+
show the reaction diagram
-
-
-
-
r
5alpha-androstane-3beta,17beta-diol + NADP+
5alpha-androstane-17beta-ol-3-one + NADPH
show the reaction diagram
-
-
-
-
r
5alpha-androstanediol + NAD+
5alpha-dihydrotestosterone + NADH
show the reaction diagram
-
-
-
-
r
5alpha-dihydrotestosterone + NADPH
5alpha-androstane-3beta,17beta-diol + NADP+
show the reaction diagram
-
-
-
-
?
5alpha-dihydrotestosterone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
5alpha-pregnan-3beta-ol-20-one + NAD+
5alpha-pregnan-3,20-dione + NADH
show the reaction diagram
-
-
-
-
?
5alpha-pregnane-3,20-dione + NAD(P)H
5alpha-pregnane-3beta-ol-20-one + NAD(P)+
show the reaction diagram
5alpha-pregnane-3,20-dione + NADH
5alpha-pregnane-3beta-ol-20-one + NAD+
show the reaction diagram
-
-
-
r
5alpha-pregnane-3,20-dione + NADPH
5beta-pregnane-3,20-dione + NADPH
show the reaction diagram
-
-
-
-
r
5alpha-pregnane-3beta-ol-20-one + NAD+
5alpha-pregnane-3,20-dione + NADH
show the reaction diagram
-
-
-
r
5alpha-pregnane-3beta-ol-20-one + NADP+
5alpha-pregnane-3,20-dione + NADPH
show the reaction diagram
-
-
-
-
r
5beta-androstan-17beta-ol-3-one + NADPH
5beta-androstane-3beta,17beta-diol + NADP+
show the reaction diagram
-
-
-
-
r
5beta-androstan-3beta-ol-17-one + NADP+
5beta-androstane-3,17-dione + NADPH
show the reaction diagram
-
-
-
-
r
5beta-androstane-3,17-dione + NADPH
3beta-hydroxy-5beta-androstane-17-one + NADP+
show the reaction diagram
-
-
-
-
?
5beta-androstane-3,17-dione + NADPH
5beta-androstan-3beta-ol-17-one + NADP+
show the reaction diagram
-
-
-
-
r
5beta-androstane-3beta,17beta-diol + NADP+
5beta-androstan-17beta-ol-3-one + NADPH
show the reaction diagram
-
-
-
-
r
5beta-pregnan-20alpha-ol-3-one + NADPH + H+
5beta-pregnan-3beta,20alpha-diol + NADP+
show the reaction diagram
-
-
-
-
r
5beta-pregnan-3beta-ol-20-one + NADP+
5beta-pregnan-3,20-dione + NADPH
show the reaction diagram
-
-
-
-
r
5beta-pregnane-3,20-dione + NAD(P)H + H+
5beta-pregnane-3beta-ol-20-one + NAD(P)+
show the reaction diagram
5beta-pregnane-3,20-dione + NADH + H+
5beta-pregnane-3beta-ol-20-one + 5beta-pregnane-3alpha-ol-20-one + NAD+
show the reaction diagram
-
-
-
r
5beta-pregnane-3,20-dione + NADPH + H+
5beta-pregnan-3beta-ol-20-one + NADP+
show the reaction diagram
-
-
-
-
r
5beta-pregnane-3beta,20alpha-diol + NADP+
5beta-pregnane-20alpha-ol-3-one + NADPH + H+
show the reaction diagram
-
-
-
-
r
5beta-pregnane-3beta-ol-20-one + NAD+
5beta-pregnane-3,20-dione + NADH + H+
show the reaction diagram
-
-
-
r
6-tert-butyl-2,3-epoxy-5-cyclohexene-1,4-dione + NADPH
? + NADP+
show the reaction diagram
-
major product has S-configuration
-
-
r
7alpha,25-dihydroxycholesterol + NAD+
7alpha,25-dihydroxy-4-cholesten-3-one + NADH
show the reaction diagram
-
-
-
-
?
7alpha,27-dihydroxycholesterol + NAD+
7alpha,27-dihydroxy-4-cholesten-3-one + NADH
show the reaction diagram
-
-
-
-
?
7alpha-hydroxycholesterol + NAD+
7alpha-hydroxy-4-cholesten-3-one + NADH
show the reaction diagram
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
?
show the reaction diagram
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
? + NADP+
show the reaction diagram
all-trans-retinal + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
all-trans-retinol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
r
androst-5-en-3,17-dione + NADH
dehydroepiandrosterone + NAD+
show the reaction diagram
-
-
-
-
r
androst-5-ene-3beta-ol-17-one + NAD+
androst-5-ene-3,17-dione + NADH
show the reaction diagram
androstendiol + NAD+
testosterone + NADH + H+
show the reaction diagram
androstenedione + NADPH + H+
3beta-hydroxy-5-androsten-17-one + NADP+
show the reaction diagram
-
-
-
-
?
androstenone + NADH
beta-androstenol + NAD+
show the reaction diagram
-
-
-
?
benzil + NADPH
(R)-benzoin + NADP+
show the reaction diagram
-
enantiomeric purity of 97% enantiomeric excess
-
-
r
camphorquinone + NADPH + H+
camphorquinol + NADP+
show the reaction diagram
-
-
-
-
?
caprinaldehyde + NADPH
?
show the reaction diagram
-
-
-
-
?
cholesterol + NAD+
cholest-5-en-3-one + NADH
show the reaction diagram
-
-
-
-
?
cyclohexanone + NADPH
cyclohexanol + NADP+
show the reaction diagram
-
-
-
-
?
D-galactose + NADPH
?
show the reaction diagram
-
-
-
-
?
D-glucose + NADPH
?
show the reaction diagram
-
-
-
-
?
D-glucuronic acid + NADPH
?
show the reaction diagram
-
-
-
-
?
D-glyceraldehyde + NADPH
?
show the reaction diagram
-
-
-
-
?
D-xylose + NADPH
?
show the reaction diagram
-
-
-
-
?
dehydroepiandrosterone + NAD+
?
show the reaction diagram
dehydroepiandrosterone + NAD+
androst-5-en-3,17-dione + NADH
show the reaction diagram
dehydroepiandrosterone + NAD+
androst-5-en-3,17-dione + NADH + H+
show the reaction diagram
dehydroepiandrosterone + NADH + H+
androsterone + NAD+
show the reaction diagram
-
-
-
-
?
dehydroepiandrosterone + NADPH
3beta-hydroxy-5-androsten-17-one + NADP+
show the reaction diagram
-
-
-
-
?
dehydrolithocholic acid + NADPH
isolithocholic acid + NADP+
show the reaction diagram
-
-
-
-
r
DELTA5-3beta-hydroxysteroid + NAD+
DELTA4-3-oxosteroid + NADH + H+
show the reaction diagram
diacetyl + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
dimethyl-2-oxo-glutarate + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
hexanophenone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
hydritantin + NADPH
?
show the reaction diagram
-
-
-
-
?
isatin + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
isolithocholic acid + NADP+
dehydrolithocholic acid + NADPH
show the reaction diagram
-
-
-
-
r
menadione + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
menadione + NADPH
menadiol + NADP+
show the reaction diagram
-
-
-
-
?
methylglyoxal + NADPH
?
show the reaction diagram
-
-
-
-
?
n-butyrophenone + NADPH
(S)-1-phenyl1-butanol + NADP+
show the reaction diagram
-
major product
-
-
r
phenylglyoxal + NADPH
?
show the reaction diagram
-
-
-
-
?
pregnenolone + NAD(P)+
pregn-5-en-3,20-dione + NAD(P)H
show the reaction diagram
pregnenolone + NAD+
isoprogesterone + NADH + H+
show the reaction diagram
pregnenolone + NAD+
isoprogesterone + progesterone + NADH
show the reaction diagram
-
about 90% odf product is isoprogesterone
-
r
pregnenolone + NAD+
pregn-5-en-3,20-dione + NADH
show the reaction diagram
pregnenolone + NAD+
progesterone + NADH
show the reaction diagram
pregnenolone + NAD+
progesterone + NADH + H+
show the reaction diagram
progesterone + NADPH
3beta-hydroxy-4-pregnen-20-one + NADP+
show the reaction diagram
-
-
-
-
?
prostaglandin E1 + NADPH
?
show the reaction diagram
-
-
-
-
?
prostaglandin E2 + NADPH
?
show the reaction diagram
-
-
-
-
?
pyridine-4-aldehyde + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
sitosterol + NAD+
3-oxo-24-ethyl-cholest-5-ene + NADH + H+
show the reaction diagram
testosterone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
testosterone + NADPH + H+
3beta,17beta-dihydroxy-4-androsten + NADP+
show the reaction diagram
-
-
-
-
?
valerophenone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
additional information
?
-