1.1.1.145: 3beta-hydroxy-DELTA5-steroid dehydrogenase

This is an abbreviated version, for detailed information about 3beta-hydroxy-DELTA5-steroid dehydrogenase, go to the full flat file.

Reaction

a 3beta-hydroxy-DELTA5-steroid
+
NAD+
=
a 3-oxo-DELTA5-steroid
+
NADH
+
H+

Synonyms

3-beta-hydroxy-5-ene steroid dehydrogenase, 3-beta-hydroxy-delta(5)-steroid dehydrogenase, 3-beta-hydroxysteroid dehydrogenase, 3-beta-hydroxysteroid dehydrogenase type-2, 3beta hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-HSD type II, 3beta-HSD1, 3beta-HSD2, 3beta-HSD22, 3beta-HSDH, 3beta-HSD_1, 3beta-hydroxy steroid dehydrogenase/5-ene-4-ene isomerase, 3beta-hydroxy steroid dehydrogenase/isomerase, 3beta-hydroxy-5-ene steroid dehydrogenase, 3beta-hydroxy-5-ene-steroid dehydrogenase, 3beta-hydroxy-5-ene-steroid oxidoreductase, 3beta-hydroxy-DELTA5-C27-steroid dehydrogenase/isomerase, 3beta-hydroxy-DELTA5-C27-steroid oxidoreductase, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase 1, 3beta-hydroxysteroid dehydrogenase 2, 3beta-hydroxysteroid dehydrogenase type 1, 3beta-hydroxysteroid dehydrogenase type 2, 3beta-hydroxysteroid dehydrogenase type 2 and, 3beta-hydroxysteroid dehydrogenase type II, 3beta-hydroxysteroid dehydrogenase type1, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELAT4 isomerase type 2, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase type II, 3beta-hydroxysteroid dehydrogenase/isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase type 1, 3betaHSD, 3betaHSD1, 3betaHSD2, 5-ene-3-beta-hydroxysteroid dehydrogenase, 5alpha-dihydrotestosterone 3beta-hydroxysteroid dehydrogenase, dehydrogenase, 3beta-hydroxy-DELTA5-steroid, DELTA5-3beta-hydroxysteroid dehydrogenase, DHRS4, HSD2, HSD3B, HSD3B1, HSD3B2, Hsd3b6, HSDB1, HSDH, More, progesterone reductase, steroid-DELTA5-3beta-ol dehydrogenase, type 1 3beta-hydroxysteroid dehydrogenase, type 1 3beta-hydroxysteroid dehydrogenase/isomerase, type 2 3beta-hydroxysteroid dehydrogenase, type 2 3beta-hydroxysteroid dehydrogenase/isomerase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase

Source Tissue

Source Tissue on EC 1.1.1.145 - 3beta-hydroxy-DELTA5-steroid dehydrogenase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
abdominal, expression level determination, especially in female aorta with mild atherosclerotic changes
Manually annotated by BRENDA team
-
cardenolide-free cell suspension culture
Manually annotated by BRENDA team
-
3betaHSD VI
Manually annotated by BRENDA team
-
preovulatory follicular
Manually annotated by BRENDA team
-
adrenal cell line
Manually annotated by BRENDA team
-
induction by peroxisome-proliferator-activated receptor alpha ligands
Manually annotated by BRENDA team
-
in females, the level is the highest in the hypothalamus; in males, the highest transcript level is in telencephalon and hypothalamus
Manually annotated by BRENDA team
-
in the preparatory phase, the highest transcript level is seen in medulla oblongata in pituitary in males
Manually annotated by BRENDA team
-
HSDB1 transcript abundance in the endometrium and myometrium remain at the same level during the examined days of pregnancy. After luteolysis both endometrial and myometrial HSD3B1 expression wane
Manually annotated by BRENDA team
-
in females, the highest transcript level is in olfactory bulb; in females, the level is the lowest in olfactory bulb and pituitary
Manually annotated by BRENDA team
-
in the preparatory phase, the lowest transcript level is seen in pituitary in males. In females, the level is the lowest in olfactory bulb and pituitary
Manually annotated by BRENDA team
-
in females and males, the lowest transcript level is in pituitary
Manually annotated by BRENDA team
-
3beta-Hydroxysteroid dehydrogenase protein is present in the glandular epithelia and endothelia of blood vessels without difference in distribution pattern between normal and hyperplastic prostate
Manually annotated by BRENDA team
-
in males, the highest transcript level is in telencephalon and hypothalamus
Manually annotated by BRENDA team
-
in amnion epithelium immunoreactive 3betaHSD is found from first to third trimester and term
Manually annotated by BRENDA team
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HSDB1 transcript abundance in the endometrium and myometrium remain at the same level during the examined days of pregnancy. After luteolysis both endometrial and myometrial HSD3B1 expression wane
Manually annotated by BRENDA team
-
3betaHSD VI
Manually annotated by BRENDA team
additional information