1.1.1.145: 3beta-hydroxy-DELTA5-steroid dehydrogenase

This is an abbreviated version, for detailed information about 3beta-hydroxy-DELTA5-steroid dehydrogenase, go to the full flat file.

Reaction

a 3beta-hydroxy-DELTA5-steroid
+
NAD+
=
a 3-oxo-DELTA5-steroid
+
NADH
+
H+

Synonyms

3-beta-hydroxy-5-ene steroid dehydrogenase, 3-beta-hydroxy-delta(5)-steroid dehydrogenase, 3beta hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-HSD type II, 3beta-HSD1, 3beta-HSD2, 3beta-HSD22, 3beta-HSDH, 3beta-HSD_1, 3beta-hydroxy steroid dehydrogenase/5-ene-4-ene isomerase, 3beta-hydroxy steroid dehydrogenase/isomerase, 3beta-hydroxy-5-ene steroid dehydrogenase, 3beta-hydroxy-5-ene-steroid dehydrogenase, 3beta-hydroxy-5-ene-steroid oxidoreductase, 3beta-hydroxy-DELTA5-C27-steroid dehydrogenase/isomerase, 3beta-hydroxy-DELTA5-C27-steroid oxidoreductase, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase 1, 3beta-hydroxysteroid dehydrogenase type 1, 3beta-hydroxysteroid dehydrogenase type 2, 3beta-hydroxysteroid dehydrogenase type II, 3beta-hydroxysteroid dehydrogenase type1, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELAT4 isomerase type 2, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase type II, 3beta-hydroxysteroid dehydrogenase/isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase type 1, 3betaHSD, 3betaHSD1, 3betaHSD2, 5-ene-3-beta-hydroxysteroid dehydrogenase, 5alpha-dihydrotestosterone 3beta-hydroxysteroid dehydrogenase, dehydrogenase, 3beta-hydroxy-DELTA5-steroid, DELTA5-3beta-hydroxysteroid dehydrogenase, DHRS4, HSD3B, HSD3B2, HSDB1, More, progesterone reductase, steroid-DELTA5-3beta-ol dehydrogenase, type 1 3beta-hydroxysteroid dehydrogenase, type 1 3beta-hydroxysteroid dehydrogenase/isomerase, type 2 3beta-hydroxysteroid dehydrogenase, type 2 3beta-hydroxysteroid dehydrogenase/isomerase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase

KM Value

KM Value on EC 1.1.1.145 - 3beta-hydroxy-DELTA5-steroid dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.24
(S)-1-indanol
-
pH 7.4, 25C
0.093
(S)-1-tetralol
-
pH 7.4, 25C
0.0084
(S)-phenyl-1-butanol
-
pH 7.4, 25C
0.089
1,4-Naphthoquinone
-
pH 7.4, 25C
0.0052
1-phenylisatin
-
pH 7.4, 25C
0.0038
11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione
-
-
0.0827
11beta,17alpha,21-trihydroxy-5alpha-pregnane-3,20-dione
-
-
0.0461
11beta,17alpha,21-trihydroxy-5beta-pregnane-3,20-dione
-
-
0.0621
13,14-dihydro-15-keto-prostaglandin F2
-
-
0.13
13,14-dihydro-15-keto-prostaglandin F2alpha
-
-
0.004 - 0.0196
16alpha-hydroxy-dehydroepiandrosterone
0.0014 - 0.0184
16beta-hydroxy-dehydroepiandrosterone
0.206
17-hydroxyprogesterone
-
-
0.0035 - 0.018
17alpha-hydroxypregnenolone
0.684
17beta-hydroxy-5alpha-androstane-3-one
-
-
0.231
17beta-hydroxy-5beta-androstane-3-one
-
-
0.2
2,3-heptanedione
-
pH 7.4, 25C
0.55
2,3-Hexanedione
-
pH 7.4, 25C
10
2,3-Pentanedione
-
pH 7.4, 25C
0.0053
3beta,17alpha-dihydroxy-5-pregen-20-one
-
-
0.0015
4,4'-dimethylbenzil
-
pH 7.4, 25C
1
4-benzoylpyridine
-
pH 7.4, 25C
2.097
4-benzylpyridine
-
-
0.319
4-carboxybenzaldehyde
-
-
0.16
4-hexanoylpyridine
-
pH 7.4, 25C
0.137
4-Nitroacetophenone
-
-
1.966 - 13
4-Nitrobenzaldehyde
0.642
5-androsten-3beta-ol-17-one
-
pH 7.8, 30C
0.0144 - 0.0147
5-androstene-3,17-dione
0.0167 - 0.0179
5alpha-Androstan-3beta-ol-17-one
0.028 - 1.043
5alpha-androstane-3,17-dione
0.016
5alpha-dihydrotestosterone
-
pH 7.4, 25C
0.196 - 0.217
5alpha-pregnane-3,20-dione
0.116 - 0.12
5alpha-pregnane-3beta-ol-20-one
0.0049
5beta-androstan-17beta-ol-3-one
-
pH 7.4, 25C
0.0079
5beta-androstan-3beta-ol-17-one
-
pH 7.4, 25C
0.01 - 0.123
5beta-androstane-3,17-dione
0.0041
5beta-androstane-3beta,17beta-diol
-
pH 7.4, 25C
0.0097
5beta-pregnan-20alpha-ol-3-one
-
pH 7.4, 25C
0.008
5beta-Pregnan-3beta-ol-20-one
-
pH 7.4, 25C
0.0029 - 1.725
5beta-pregnane-3,20-dione
0.008
5beta-pregnane-3beta,20alpha-diol
-
pH 7.4, 25C
0.11 - 0.314
5beta-pregnane-3beta-ol-20-one
0.12
6-tert-butyl-2,3-epoxy-5-cyclohexene-1,4-dione
-
pH 7.4, 25C
0.003
7alpha,27-dihydroxycholesterol
-
-
0.0032
7alpha-hydroxycholesterol
-
-
0.0036 - 2.408
9,10-phenanthrenequinone
0.024
all-trans-retinal
-
pH 7.4, 25C
0.001
allopregnanolone
-
-
0.13
androst-5-ene-3beta-ol-17-one
-
NAD+ as cofactor
0.00016 - 0.00046
androstanediol
0.001
androstenediol
-
-
0.0703
androstenedione
-
-
0.005
benzil
-
pH 7.4, 25C
0.555
Camphorquinone
-
-
0.69
caprinaldehyde
-
-
1.663
cyclohexanone
-
-
0.287
D-galactose
-
-
0.122
D-glucose
-
-
0.465
D-glucuronic acid
-
-
1.07
D-glyceraldehyde
-
-
0.467
D-xylose
-
-
0.00009 - 0.221
dehydroepiandrosterone
0.035
Dehydrolithocholic acid
-
pH 7.4, 25C
54
diacetyl
-
pH 7.4, 25C
1.4
dimethyl-2-oxo-glutarate
-
pH 7.4, 25C
0.036
hexanophenone
-
pH 7.4, 25C
0.466
hydritantin
-
-
0.32
isatin
-
pH 7.4, 25C
0.18 - 0.693
menadione
2.651
methylglyoxal
-
-
0.048
n-butyrophenone
-
pH 7.4, 25C
0.0000047 - 0.27
NAD+
0.0025 - 0.106
NADH
0.0003 - 13
NADP+
0.0003
NADPH
-
pH 7.4, 25C
2.366
Phenylglyoxal
-
-
0.00004 - 0.09
pregnenolone
0.0346
progesterone
-
-
0.373
prostaglandin E1
-
-
0.0152
prostaglandin E2
-
-
21
Pyridine-4-aldehyde
-
pH 7.4, 25C
0.0055 - 0.0068
stanolone
0.0583
testosterone
-
-
0.054
valerophenone
-
pH 7.4, 25C
additional information
additional information
-