1.1.1.144: perillyl-alcohol dehydrogenase

This is an abbreviated version, for detailed information about perillyl-alcohol dehydrogenase, go to the full flat file.

Reaction

perillyl alcohol
+
NAD+
=
perillyl aldehyde
+
NADH
+
H+

Synonyms

ADH, dehydrogenase, perillyl alcohol, perillyl alcohol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.144 perillyl-alcohol dehydrogenase

Engineering

Engineering on EC 1.1.1.144 - perillyl-alcohol dehydrogenase

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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
R50H
-
mutation of active site arginine to a histidine can switch substrate specificity of the enzyme benzyl alcohol dehydrogenase (EC 1.1.1.90) so that it has a very much greater preference for perillyl alcohol than for benzyl alcohol