1.1.1.141: 15-hydroxyprostaglandin dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about 15-hydroxyprostaglandin dehydrogenase (NAD+), go to the full flat file.

Reaction

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate
+
NAD+
=
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate
+
NADH
+
H+

Synonyms

11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase, 15-hydroxy prostaglandin dehydrogenase, 15-hydroxyprostaglandin dehydrogenase, 15-hydroxyprostaglandin-dehydrogenase, 15-hydroxyprostanoic dehydrogenase, 15-OH-PGDH, 15-PGDH, 15-prostaglandin dehydrogenase, dehydrogenase, 15-hydroxyprostaglandin, HPGD, NAD+ dependent 15-hydroxyprostaglandin dehydrogenase, NAD+ dependent PGDH, NAD+-15-hydroxy prostanoate oxidoreductase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I), NAD+-dependent 15-PGDH, NAD+-linked 15-hydroxyprostaglandin dehydrogenase, NAD-dependent 15-hydroxyprostaglandin dehydrogenase, NAD-specific 15-hydroxyprostaglandin dehydrogenase, PGDH, prostaglandin dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+)

Substrates Products

Substrates Products on EC 1.1.1.141 - 15-hydroxyprostaglandin dehydrogenase (NAD+)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
show the reaction diagram
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
show the reaction diagram
-
-
i.e. 15-hydroxyprostaglandin or (15S)-PGE2
-
r
(5Z,8E,10E,12S)-12-hydroxy-5,8,10-heptadecatrienoic acid + NAD+
(5Z,8E,10E)-12-oxo-5,8,10-heptadecatrienoic acid + NADH
show the reaction diagram
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
show the reaction diagram
15(S)-hydroperoxy-5,8,11,13-(Z,Z,Z,E)-eicosatetraenoic acid + NAD+
15-oxo-5,8,11,13-(Z,Z,Z,E)-eicosatetraenoic acid + NADH
show the reaction diagram
-
-
-
-
?
15-hydroxyeicosatetraenoic acid + NAD+
15-ketoeicosatetraenoic acid + NADH
show the reaction diagram
-
-
-
?
15-hydroxyprostaglandin + NAD+
15-oxoprostaglandin + NADH + H+
show the reaction diagram
19-hydroxyprostaglandin E1 + NAD+
19-hydroxy-15-oxoprostaglandin E1 + NADH
show the reaction diagram
-
-
-
?
20-hydroxyprostaglandin E1 + NAD+
20-hydroxy-15-ketoprostaglandin E1 + NADH
show the reaction diagram
-
-
-
?
5,6-chrysenequinone + NADH
?
show the reaction diagram
-
-
-
-
?
5,6-chrysenequinone + NADH
? + H2O2
show the reaction diagram
-
formation of potentially hazardous semiquinones, reaction mechanism, overview
-
-
?
6-keto-prostaglandin E1 + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
6-keto-prostaglandin F1alpha + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
6-ketoprostaglandin E1 + NAD+
6,15-diketoprostaglandin E1
show the reaction diagram
-
-
-
?
6-ketoprostaglandin F1alpha + NAD+
6,15-diketoprostaglandin F1alpha
show the reaction diagram
-
-
-
?
6-ketoprostaglandin F1alpha + NAD+
6,15-diketoprostaglandin F1alpha + NADH + H+
show the reaction diagram
-
-
-
?
9,10-phenanthrenequinone + NADH
?
show the reaction diagram
-
-
-
-
?
9,10-phenanthrenequinone + NADH
? + H2O2
show the reaction diagram
-
formation of potentially hazardous semiquinones, reaction mechanism, overview
-
-
?
prostaglandin A1 + NAD+
15-ketoprostaglandin A1 + NADH + H+
show the reaction diagram
prostaglandin A1 + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
prostaglandin A2 + NAD+
15-ketoprostaglandin A2 + NADH + H+
show the reaction diagram
prostaglandin D1 + NAD+
15-ketoprostaglandin D1 + NADH + H+
show the reaction diagram
-
very low activity
-
?
prostaglandin D2 + NAD+
15-ketoprostaglandin D2 + NADH + H+
show the reaction diagram
prostaglandin D2 + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
prostaglandin E1 + NAD+
15-ketoprostaglandin E1 + NADH + H+
show the reaction diagram
prostaglandin E1 + NAD+
? + NADH
show the reaction diagram
prostaglandin E2 + NAD+
15-ketoprostaglandin E2 + NADH + H+
show the reaction diagram
prostaglandin E2 + NAD+
15-oxoprostaglandin E2 + NADH + H+
show the reaction diagram
-
-
-
-
?
prostaglandin E3 + NAD+
15-keto-prostaglandin E3 + NADH + H+
show the reaction diagram
-
-
-
?
prostaglandin F2alpha + NAD(P)+
15-ketoprostaglandin F2alpha + NADH + H+
show the reaction diagram
prostaglandin F2alpha + NAD+
15-ketoprostaglandin F2alpha + NADH + H+
show the reaction diagram
-
-
-
-
?
prostaglandin F2alpha + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
prostaglandin I2 + NAD+
15-ketoprostaglandin I2 + NADH + H+
show the reaction diagram
-
-
-
?
additional information
?
-