1.1.1.141: 15-hydroxyprostaglandin dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about 15-hydroxyprostaglandin dehydrogenase (NAD+), go to the full flat file.

Reaction

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate
+
NAD+
=
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate
+
NADH
+
H+

Synonyms

11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase, 15-hydroxy prostaglandin dehydrogenase, 15-hydroxyprostaglandin dehydrogenase, 15-hydroxyprostaglandin-dehydrogenase, 15-hydroxyprostanoic dehydrogenase, 15-OH-PGDH, 15-PGDH, 15-prostaglandin dehydrogenase, dehydrogenase, 15-hydroxyprostaglandin, HPGD, NAD+ dependent 15-hydroxyprostaglandin dehydrogenase, NAD+ dependent PGDH, NAD+-15-hydroxy prostanoate oxidoreductase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I), NAD+-dependent 15-PGDH, NAD+-linked 15-hydroxyprostaglandin dehydrogenase, NAD-dependent 15-hydroxyprostaglandin dehydrogenase, NAD-specific 15-hydroxyprostaglandin dehydrogenase, PGDH, prostaglandin dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+)

Source Tissue

Source Tissue on EC 1.1.1.141 - 15-hydroxyprostaglandin dehydrogenase (NAD+)

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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non-small cell lung carcinoma cell line A549, expression of 15-PGDH is induced by dexamethason, prednisolone, betamethasone and triamcinolone
Manually annotated by BRENDA team
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both 15-hydroxyprostaglandin dehydrogenase mRNA and protein levels are significantly higher in kidney cortex than in papilla. Enzyme is mainly localized to the tubular epithelial cells in kidney cortex and outer medulla
Manually annotated by BRENDA team
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55000 Da form of enzyme, level increases with preterm premature rupture of membrane
Manually annotated by BRENDA team
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low expression
Manually annotated by BRENDA team
-
low enzyme expression level
Manually annotated by BRENDA team
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lung adenocarcinoma cell line
Manually annotated by BRENDA team
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15-hydroxyprostaglandin dehydrogenase is expressed mainly in keratinocytes and melanocytes
Manually annotated by BRENDA team
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erythroleukemia cell line
Manually annotated by BRENDA team
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invasiveapocrine carcinoma cells correspond to a distinct molecular subtype of breast carcinomas characterized by the expression of 15-prostaglandin dehydrogenase alone or in combination with a novel form of acyl-CoA synthetase medium-chain family member 1, 15-prostaglandin dehydrogenase is not expressed by other breast cancer types
Manually annotated by BRENDA team
-
in hair follicle, 15-hydroxyprostaglandin dehydrogenase is expressed mainly in keratinocytes and melanocytes
Manually annotated by BRENDA team
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intense immunofluorescent staining for 15-hydroxyprostaglandin dehydrogenase in macula densa and glomerulus of cyclooxygenase-2 knock-out mice
Manually annotated by BRENDA team
-
high enzyme expression level
Manually annotated by BRENDA team
-
low enzyme expression level
Manually annotated by BRENDA team
-
in hair follicle, 15-hydroxyprostaglandin dehydrogenase is expressed mainly in keratinocytes and melanocytes
Manually annotated by BRENDA team
-
high expression level of 15-PGDH
Manually annotated by BRENDA team
-
macula densa cell line, significantly lower enzyme levels than in a proximal tubule cell line. Treatment with an inhibitor of cyclooxygenase-2 increases enzyme level
Manually annotated by BRENDA team
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enzyme activity is reduced in inflamed mucosa
Manually annotated by BRENDA team
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intense immunofluorescent staining for 15-hydroxyprostaglandin dehydrogenase in macula densa and glomerulus of cyclooxygenase-2 knock-out mice
Manually annotated by BRENDA team
-
enzyme is mainly localized to the tubular epithelial cells in kidney cortex and outer medulla
Manually annotated by BRENDA team
-
low expression level of 15-PGDH
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
very low enzyme expression level
Manually annotated by BRENDA team
-
low enzyme expression level
Manually annotated by BRENDA team
the enzyme is expressed mainly in the glandular epithelium, enzyme activity during the oestrous cycle and early pregnancy, overview
Manually annotated by BRENDA team
-
PGDH messenger RNA (mRNA) abundance decreases significantly in the visceral yolk sac membrane and the amnion throughout the last third of pregnancy
Manually annotated by BRENDA team
additional information