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1.1.1.141: 15-hydroxyprostaglandin dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about 15-hydroxyprostaglandin dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.1.1.141

Reaction

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate
+
NAD+
=
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate
+
NADH
+
H+

Synonyms

11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase, 15-hydroxy prostaglandin dehydrogenase, 15-hydroxy-prostaglandin-dehydrogenase, 15-hydroxyprostaglandin dehydrogenase, 15-hydroxyprostaglandin-dehydrogenase, 15-hydroxyprostanoic dehydrogenase, 15-OH-PGDH, 15-PGDH, 15-prostaglandin dehydrogenase, dehydrogenase, 15-hydroxyprostaglandin, HPGD, NAD+ dependent 15-hydroxyprostaglandin dehydrogenase, NAD+ dependent PGDH, NAD+-15-hydroxy prostanoate oxidoreductase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I), NAD+-dependent 15-PGDH, NAD+-linked 15-hydroxyprostaglandin dehydrogenase, NAD-dependent 15-hydroxyprostaglandin dehydrogenase, NAD-specific 15-hydroxyprostaglandin dehydrogenase, nicotinamide adenine dinucleotide-dependent 15-hydroxyprostaglandin dehydrogenase, PGDH, prostaglandin dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+)

Reference

Reference on EC 1.1.1.141 - 15-hydroxyprostaglandin dehydrogenase (NAD+)

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lee, S.C.; Levine, L.
Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types
J. Biol. Chem.
250
548-552
1975
Canis lupus familiaris, Gallus gallus, Homo sapiens, Platyrrhini, Sus scrofa
Manually annotated by BRENDA team
Lee, S.C.; Pong, S.S.; Katzen, D.; Wu, K.Y.; Levine, L.
Distribution of prostaglandin E 9-ketoreductase and type I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex
Biochemistry
14
142-145
1975
Sus scrofa
Manually annotated by BRENDA team
Tombach, B.; Kusseler, R.; Schlegel, W.
Purification of human placental prostaglandin 15-hydroxydehydrogenase
J. Chromatogr.
521
231-238
1990
Homo sapiens
Manually annotated by BRENDA team
Braithwaite, S.S.; Jabarak, J.
Studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Purification and partial characterization
J. Biol. Chem.
250
2315-2318
1975
Homo sapiens
Manually annotated by BRENDA team
Jabarak, J.; Braithwaite, S.S.
Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta
Arch. Biochem. Biophys.
177
245-254
1976
Homo sapiens
Manually annotated by BRENDA team
Saeed, S.A.; Roy, A.C.
Purification of 15-hydroxy prostaglandin dehydrogenase from bovine lung
Biochem. Biophys. Res. Commun.
47
96-102
1972
Bos taurus
Manually annotated by BRENDA team
Iijima, Y.; Ueno, T.; Sasagawa, K.; Yamazaki, M.
Inhibition of 15-hydroxyprostaglandin dehydrogenase by papaverine
Biochem. Biophys. Res. Commun.
80
484-489
1978
Canis lupus familiaris, Cavia porcellus, Gallus gallus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Jung, A.; Schlegel, W.; Jackisch, R.; Friedrich, E.J.; Wendel, A.; Ruckrich, M.F.
15-Hydroxyprostaglandin dehydrogenase from human placenta. 1. Isolation and characterization
Hoppe-Seyler's Z. Physiol. Chem.
356
787-798
1975
Homo sapiens
Manually annotated by BRENDA team
Ruckrich, M.F.; Wendel, A.; Schlegel, W.; Jackisch, R.; Jung, A.
15-Hydroxyprostaglandin dehydrogenase from human placenta, II. Steady state kinetics and influence of prostaglandin F2alpha analogues
Hoppe-Seyler's Z. Physiol. Chem.
356
799-809
1975
Homo sapiens
Manually annotated by BRENDA team
Bergholte, J.M.; Okita, R.T.
Isolation and properties of lung 15-hydroxyprostaglandin dehydrogenase from pregnant rabbits
Arch. Biochem. Biophys.
245
308-315
1986
Oryctolagus cuniculus
Manually annotated by BRENDA team
Krook, M.; Marekov, L.; Jörnvall, H.
Purification and structural characterization of placental NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase. The primary structure reveals the enzyme to belong to the short-chain alcohol dehydrogenase family
Biochemistry
29
738-743
1990
Homo sapiens
Manually annotated by BRENDA team
Jabarak, J.
Isolation and properties of an NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from human placenta
Methods Enzymol.
86
126-130
1982
Homo sapiens
Manually annotated by BRENDA team
Kung-Chao, D.T.Y.; Tai, H.H.
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from porcine kidney. II. Kinetic studies
Biochim. Biophys. Acta
614
14-24
1980
Sus scrofa
Manually annotated by BRENDA team
Mak, O.T.; Liu, Y.; Tai, H.H.
Purification and characterization of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase from porcine kidney
Biochim. Biophys. Acta
1035
190-196
1990
Sus scrofa
Manually annotated by BRENDA team
Hansen, H.S.
Inhibition by indomethacin and aspirin of 15-hydroxyprostaglandin dehydrogenase in vitro
Prostaglandins
8
95-105
1974
Bos taurus
Manually annotated by BRENDA team
Schlegel, W.; Demers, L.M.; Hildebrandt-Stark, H.E.; Behrman, H.R.; Greep, R.O.
Partial purification of human placental 15-hydroxy-prostaglandin dehydrogenase: kinetic properties
Prostaglandins
5
417-433
1974
Homo sapiens
Manually annotated by BRENDA team
Tai, H.H.
Assay of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase using (15S)-[15-3H]PGE2
Methods Enzymol.
86
131-135
1982
Sus scrofa
Manually annotated by BRENDA team
Sakuma, S.; Fujimoto, Y.; Hikita, E.; Okano, Y.; Yamamoto, I.; Fujita, T.
Effects of metal ions on 15-hydroxy prostaglandin dehydrogenase activity in rabbit kidney cortex
Prostaglandins
40
507-514
1990
Oryctolagus cuniculus
Manually annotated by BRENDA team
Treissman, D.; Smith, G.N.; Patrick, J.; Brien, J.F.
Effect of ethanol on 15-hydroxyprostaglandin dehydrogenase activity in the brain stem of the near-term fetal sheep
Dev. Pharmacol. Ther.
16
48-52
1991
Ovis aries
Manually annotated by BRENDA team
Xun, C.Q.; Ensor, C.M.; Tai, H.H.
Regulation of synthesis and activity of NAD+-dependent 15-hydroxy-prostaglandin dehydrogenase (15-PGDH) by dexamethasone and phorbol ester in human erythroleukemia (HEL) cells
Biochem. Biophys. Res. Commun.
177
1258-1265
1991
Homo sapiens
Manually annotated by BRENDA team
Jarabak, J.
Polycyclic aromatic hydrocarbon quinones may be either substrates for or irreversible inhibitors of the human placental NAD-linked 15-hydroxyprostaglandin dehydrogenase
Arch. Biochem. Biophys.
292
239-243
1992
Homo sapiens
Manually annotated by BRENDA team
Mibe, M.; Nagai, K.; Oshige, T.; Mori, N.
Endogenous inhibitors of human placental prostaglandin dehydrogenase
Prostaglandins Leukot. Essent. Fatty Acids
46
241-245
1992
Homo sapiens
Manually annotated by BRENDA team
Chavan, A.J.; Ensoe, C.M.; Wu, P.; Haley, B.E.; Tai, H.H.
Photoaffinity labeling of human placental NAD+-linked 15-hydroxyprostaglandin dehydrogenase with [alpha-32]2N3NAD+
J. Biol. Chem.
268
16437-16442
1993
Homo sapiens
Manually annotated by BRENDA team
Höhl, W.; Stahl, B.; Mundkowski, R.; Hofmann, U.; Meese, C.O.; Kuhlmann, U.; Schlegel, W.
Mass determination of 15-hydroxyprostaglandin dehydrogenase from human placenta and kinetic studies with (5Z,8E,10E,12S)-12-hydroxy-5,8,10,-heptadecatrienoic acid as substrate
Eur. J. Biochem.
214
67-73
1993
Homo sapiens
Manually annotated by BRENDA team
Sakuma, S.; Fujimoto, Y.; Nakagawa, H.; Hachiki, S.; Nishida, H.; Fujita, T.
Effect of 13-hydroperoxyoctadecadienoic acid on 15-hydroxy prostaglandin dehydrogenase activity in rabbit kidney cortex
Prostaglandins
46
157-165
1993
Oryctolagus cuniculus
Manually annotated by BRENDA team
Ensoe, C.M.; Tai, H.H.
Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
Biochim. Biophys. Acta
1208
151-156
1994
Homo sapiens
Manually annotated by BRENDA team
Okita, R.T.; Okita, J.R.
Prostaglandin-metabolizing enzymes during pregnancy: characterization of NAD+-dependent prostaglandin dehydrogenase, carbonyl reductase, and cytochrome P450-dependent prostaglandin omega-hydroxylase
CRC Crit. Rev. Biochem.
31
101-126
1996
Bos taurus, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Tong, M.; Tai, H.H.
Induction of NAD+-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells
Biochem. Biophys. Res. Commun.
276
77-81
2000
Homo sapiens
Manually annotated by BRENDA team
Fujimori, K.; Okada, T.; Urade, Y.
Expression of NADP(+)-Dependent 15-Hydroxyprostaglandin Dehydrogenase mRNA in Monkey Ocular Tissues and Characterization of Its Recombinant Enzyme
J. Biochem.
131
383-389
2002
Macaca fascicularis
Manually annotated by BRENDA team
Tai, H.H.; Ensor, C.M.; Zhou, H.; Yan, F.
Structure and function of human NAD+-linked 15-hydroxyprostaglandin dehydrogenase
Adv. Exp. Med. Biol.
507
245-250
2002
Homo sapiens
Manually annotated by BRENDA team
Cho, H.; Tai, H.H.
Thiazolidinediones as a novel class of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
Arch. Biochem. Biophys.
405
247-251
2002
Homo sapiens
Manually annotated by BRENDA team
Cho, H.; Oliveira, M.A.; Tai, H.H.
Critical residues for the coenzyme specificity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
Arch. Biochem. Biophys.
419
139-146
2003
Homo sapiens
Manually annotated by BRENDA team
Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.
Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase
Arch. Biochem. Biophys.
433
447-453
2005
Homo sapiens
Manually annotated by BRENDA team
Tong, M.; Tai, H.H.
15-Hydroxyprostaglandin dehydrogenase can be induced by dexamethasone and other glucocorticoids at the therapeutic level in A549 human lung adenocarcinoma cells
Arch. Biochem. Biophys.
435
50-55
2005
Homo sapiens
Manually annotated by BRENDA team
Cho, H.; Tai, H.H.
Threonine 11 of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase may interact with NAD(+) during catalysis
Prostaglandins
66
505-509
2002
Homo sapiens
Manually annotated by BRENDA team
Cho, H.; Tai, H.H.
Inhibition of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by cyclooxygenase inhibitors and chemopreventive agents
Prostaglandins
67
461-465
2002
Homo sapiens
Manually annotated by BRENDA team
Otani, T.; Yamaguchi, K.; Scherl, E.; Du, B.; Tai, H.H.; Greifer, M.; Petrovic, L.; Daikoku, T.; Dey, S.K.; Subbaramaiah, K.; Dannenberg, A.J.
Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha
Am. J. Physiol.
290
G361-G368
2006
Homo sapiens
Manually annotated by BRENDA team
Tong, M.; Ding, Y.; Tai, H.H.
Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells
Biochem. Pharmacol.
72
701-709
2006
Homo sapiens
Manually annotated by BRENDA team
Hamza, A.; Cho, H.; Tai, H.H.; Zhan, C.G.
Understanding human 15-hydroxyprostaglandin dehydrogenase binding with NAD+ and PGE2 by homology modeling, docking and molecular dynamics simulation
Bioorg. Med. Chem.
13
4544-4551
2005
Homo sapiens
Manually annotated by BRENDA team
Mann, J.R.; Backlund, M.G.; Buchanan, F.G.; Daikoku, T.; Holla, V.R.; Rosenberg, D.W.; Dey, S.K.; DuBois, R.N.
Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression
Cancer Res.
66
6649-6656
2006
Homo sapiens
Manually annotated by BRENDA team
Wolf, I.; OKelly, J.; Rubinek, T.; Tong, M.; Nguyen, A.; Lin, B.T.; Tai, H.H.; Karlan, B.Y.; Koeffler, H.P.
15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer
Cancer Res.
66
7818-7823
2006
Homo sapiens
Manually annotated by BRENDA team
Ding, Y.; Tong, M.; Liu, S.; Moscow, J.A.; Tai, H.H.
NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer
Carcinogenesis
26
65-72
2005
Homo sapiens
Manually annotated by BRENDA team
Tong, M.; Ding, Y.; Tai, H.H.
Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells
Carcinogenesis
27
2170-2179
2006
Homo sapiens
Manually annotated by BRENDA team
Tai, H.H.; Cho, H.; Tong, M.; Ding, Y.
NAD+-linked 15-hydroxyprostaglandin dehydrogenase: structure and biological functions
Curr. Pharm. Des.
12
955-962
2006
Homo sapiens
Manually annotated by BRENDA team
Backlund, M.G.; Mann, J.R.; Holla, V.R.; Buchanan, F.G.; Tai, H.H.; Musiek, E.S.; Milne, G.L.; Katkuri, S.; DuBois, R.N.
15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer
J. Biol. Chem.
280
3217-3223
2005
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Giannoulias, D.; Haluska, G.J.; Gravett, M.G.; Sadowsky, D.W.; Challis, J.R.; Novy, M.J.
Localization of prostaglandin H synthase, prostaglandin dehydrogenase, corticotropin releasing hormone and glucocorticoid receptor in rhesus monkey fetal membranes with labor and in the presence of infection
Placenta
26
289-297
2005
Macaca mulatta
Manually annotated by BRENDA team
Myung, S.J.; Rerko, R.M.; Yan, M.; Platzer, P.; Guda, K.; Dotson, A.; Lawrence, E.; Dannenberg, A.J.; Lovgren, A.K.; Luo, G.; Pretlow, T.P.; Newman, R.A.; Willis, J.; Dawson, D.; Markowitz, S.D.
15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis
Proc. Natl. Acad. Sci. USA
103
12098-12102
2006
Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Quidville, V.; Segond, N.; Lausson, S.; Frenkian, M.; Cohen, R.; Jullienne, A.
15-Hydroxyprostaglandin-dehydrogenase is involved in anti-proliferative effect of non-steroidal anti-inflammatory drugs COX-1 inhibitors on a human medullary thyroid carcinoma cell line
Prostaglandins Other Lipid Mediat.
81
14-30
2006
Homo sapiens
Manually annotated by BRENDA team
Parent, M.; Madore, E.; MacLaren, L.A.; Fortier, M.A.
15-Hydroxyprostaglandin dehydrogenase in the bovine endometrium during the oestrous cycle and early pregnancy
Reproduction
131
573-582
2006
Bos taurus (Q309F3), Bos taurus
Manually annotated by BRENDA team
Yao, B.; Xu, J.; Harris, R.C.; Zhang, M.Z.
Renal localization and regulation of 15-hydroxyprostaglandin dehydrogenase
Am. J. Physiol. Renal Physiol.
294
F433-F439
2008
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Yang, L.; Amann, J.M.; Kikuchi, T.; Porta, R.; Guix, M.; Gonzalez, A.; Park, K.H.; Billheimer, D.; Arteaga, C.L.; Tai, H.H.; DuBois, R.; Carbone, D.P.; Johnson, D.H.
Inhibition of epidermal growth factor receptor signaling elevates 15-hydroxyprostaglandin dehydrogenase in non-small-cell lung cancer
Cancer Res.
67
5587-5593
2007
Homo sapiens
Manually annotated by BRENDA team
Huang, G.; Eisenberg, R.; Yan, M.; Monti, S.; Lawrence, E.; Fu, P.; Walbroehl, J.; Loewenberg, E.; Golub, T.; Merchan, J.; Tenen, D.G.; Markowitz, S.D.; Halmos, B.
15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer
Cancer Res.
68
5040-5048
2008
Homo sapiens
Manually annotated by BRENDA team
Michelet, J.F.; Colombe, L.; Gautier, B.; Gaillard, O.; Benech, F.; Pereira, R.; Boulle, C.; Dalko-Csiba, M.; Rozot, R.; Neuwels, M.; Bernard, B.A.
Expression of NAD(+) dependent 15-hydroxyprostaglandin dehydrogenase and protection of prostaglandins in human hair follicle
Exp. Dermatol.
17
821-828
2008
Homo sapiens (P15428), Homo sapiens
Manually annotated by BRENDA team
Chou, W.L.; Chuang, L.M.; Chou, C.C.; Wang, A.H.; Lawson, J.A.; FitzGerald, G.A.; Chang, Z.F.
Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation
J. Biol. Chem.
282
18162-18172
2007
Mus musculus
Manually annotated by BRENDA team
Pham, H.; Eibl, G.; Vincenti, R.; Chong, B.; Tai, H.H.; Slice, L.W.
15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice
Mol. Carcinog.
47
466-477
2008
Rattus norvegicus, Rattus norvegicus (O08699)
Manually annotated by BRENDA team
Roizen, J.D.; Asada, M.; Tong, M.; Tai, H.H.; Muglia, L.J.
Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice
Mol. Endocrinol.
22
105-112
2008
Mus musculus
Manually annotated by BRENDA team
Hazra, S.; Batra, R.K.; Tai, H.H.; Sharma, S.; Cui, X.; Dubinett, S.M.
Pioglitazone and rosiglitazone decrease prostaglandin E2 in non-small-cell lung cancer cells by up-regulating 15-hydroxyprostaglandin dehydrogenase
Mol. Pharmacol.
71
1715-1720
2007
Homo sapiens
Manually annotated by BRENDA team
Uppal, S.; Diggle, C.P.; Carr, I.M.; Fishwick, C.W.; Ahmed, M.; Ibrahim, G.H.; Helliwell, P.S.; Latos-Biele?ska, A.; Phillips, S.E.; Markham, A.F.; Bennett, C.P.; Bonthron, D.T.
Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy
Nat. Genet.
40
789-793
2008
Homo sapiens
Manually annotated by BRENDA team
Tai, H.H.; Tong, M.; Ding, Y.
15-hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer
Prostaglandins Other Lipid Mediat.
83
203-208
2007
Homo sapiens
Manually annotated by BRENDA team
Rizek, R.M.; Watson, C.S.; Keating, S.; Tai, H.; Challis, J.R.; Bocking, A.D.
15-Hydroxyprostaglandin dehydrogenase protein expression in human fetal membranes with and without subclinical inflammation
Reprod. Sci.
14
260-269
2007
Homo sapiens
Manually annotated by BRENDA team
Miyaki, A.; Yang, P.; Tai, H.H.; Subbaramaiah, K.; Dannenberg, A.J.
Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes
Am. J. Physiol. Gastrointest. Liver Physiol.
297
G559-G566
2009
Homo sapiens
Manually annotated by BRENDA team
Chi, X.; Freeman, B.M.; Tong, M.; Zhao, Y.; Tai, H.H.
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells
Arch. Biochem. Biophys.
487
139-145
2009
Homo sapiens
Manually annotated by BRENDA team
Hughes, D.; Otani, T.; Yang, P.; Newman, R.A.; Yantiss, R.K.; Altorki, N.K.; Port, J.L.; Yan, M.; Markowitz, S.D.; Mazumdar, M.; Tai, H.H.; Subbaramaiah, K.; Dannenberg, A.J.
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer
Cancer Prev. Res. (Phila.)
1
241-249
2008
Homo sapiens
Manually annotated by BRENDA team
Backlund, M.G.; Mann, J.R.; Holla, V.R.; Shi, Q.; Daikoku, T.; Dey, S.K.; DuBois, R.N.
Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and Snail in colorectal cancer
Cancer Res.
68
9331-9337
2008
Homo sapiens
Manually annotated by BRENDA team
Tariq, M.; Azeem, Z.; Ali, G.; Chishti, M.S.; Ahmad, W.
Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC)
J. Med. Genet.
46
14-20
2009
Homo sapiens
Manually annotated by BRENDA team
Celis, J.E.; Gromov, P.; Cabezon, T.; Moreira, J.M.; Friis, E.; Jirstroem, K.; Llombart-Bosch, A.; Timmermans-Wielenga, V.; Rank, F.; Gromova, I.
15-prostaglandin dehydrogenase expression alone or in combination with ACSM1 defines a subgroup of the apocrine molecular subtype of breast carcinoma
Mol. Cell. Proteomics
7
1795-1809
2008
Homo sapiens (P15428)
Manually annotated by BRENDA team
Wei, C.; Zhu, P.; Shah, S.J.; Blair, I.A.
15-oxo-Eicosatetraenoic acid, a metabolite of macrophage 15-hydroxyprostaglandin dehydrogenase that inhibits endothelial cell proliferation
Mol. Pharmacol.
76
516-525
2009
Homo sapiens
Manually annotated by BRENDA team
Wu, Y.; Tai, H.H.; Cho, H.
Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors
Bioorg. Med. Chem.
18
1428-1433
2010
Homo sapiens
Manually annotated by BRENDA team
Liu, Z.; Wang, X.; Lu, Y.; Du, R.; Luo, G.; Wang, J.; Zhai, H.; Zhang, F.; Wen, Q.; Wu, K.; Fan, D.
15-Hydroxyprostaglandin dehydrogenase is a tumor suppressor of human gastric cancer
Cancer Biol. Ther.
10
780-787
2010
Homo sapiens
Manually annotated by BRENDA team
Chi, X.; Tai, H.H.
Interleukin-4 up-regulates 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in human lung cancer cells
Exp. Cell Res.
316
2251-2259
2010
Homo sapiens
Manually annotated by BRENDA team
Wu, Y.; Karna, S.; Choi, C.H.; Tong, M.; Tai, H.H.; Na, D.H.; Jang, C.H.; Cho, H.
Synthesis and biological evaluation of novel thiazolidinedione analogues as 15-hydroxyprostaglandin dehydrogenase inhibitors
J. Med. Chem.
54
5260-5264
2011
Homo sapiens
Manually annotated by BRENDA team
Thill, M.; Fischer, D.; Kelling, K.; Hoellen, F.; Dittmer, C.; Hornemann, A.; Salehin, D.; Diedrich, K.; Friedrich, M.; Becker, S.
Expression of vitamin D receptor (VDR), cyclooxygenase-2 (COX-2) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in benign and malignant ovarian tissue and 25-hydroxycholecalciferol (25(OH2)D3) and prostaglandin E2 (PGE2) serum level in ovarian cancer
J. Steroid Biochem. Mol. Biol.
121
387-390
2010
Homo sapiens
Manually annotated by BRENDA team
Lu, D.; Han, C.; Wu, T.
15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPARgamma-mediated activation of p21(WAF1/Cip1.)
Oncogene
33
1101-1112
2013
Homo sapiens
Manually annotated by BRENDA team
Niesen, F.; Schultz, L.; Jadhav, A.; Bhatia, C.; Guo, K.; Maloney, D.; Pilka, E.; Wang, M.; Oppermann, U.; Heightman, T.; Simeonov, A.
High-affinity inhibitors of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships
PLoS ONE
5
e13719
2010
Homo sapiens
Manually annotated by BRENDA team
Welsh, T.; Paul, J.; Palliser, H.K.; Tabatabaee, H.; Hirst, J.; Mesiano, S.; Zakar, T.
15-Hydroxyprostaglandin dehydrogenase expression and localization in guinea pig gestational tissues during late pregnancy and parturition
Reprod. Sci.
19
1099-1109
2012
Sus scrofa
Manually annotated by BRENDA team
Liu, Y.; Jia, Z.; Sun, Y.; Zhou, L.; Downton, M.; Chen, R.; Zhang, A.; Yang, T.
Postnatal regulation of 15-hydroxyprostaglandin dehydrogenase in the rat kidney
Am. J. Physiol. Renal Physiol.
307
F388-F395
2014
Rattus norvegicus
Manually annotated by BRENDA team
Gram, A.; Buechler, U.; Boos, A.; Hoffmann, B.; Kowalewski, M.P.
Biosynthesis and degradation of canine placental prostaglandins: prepartum changes in expression and function of prostaglandin F2?-synthase (PGFS, AKR1C3) and 15-hydroxyprostaglandin dehydrogenase (HPGD)
Biol. Reprod.
89
2-2
2013
Canis lupus familiaris (E2QX67), Canis lupus familiaris
Manually annotated by BRENDA team
Duveau, D.Y.; Yasgar, A.; Wang, Y.; Hu, X.; Kouznetsova, J.; Brimacombe, K.R.; Jadhav, A.; Simeonov, A.; Thomas, C.J.; Maloney, D.J.
Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
Bioorg. Med. Chem. Lett.
24
630-635
2014
Homo sapiens (P15428), Homo sapiens
Manually annotated by BRENDA team
Choi, D.; Piao, Y.L.; Wu, Y.; Cho, H.
Control of the intracellular levels of prostaglandin E2 through inhibition of the 15-hydroxyprostaglandin dehydrogenase for wound healing
Bioorg. Med. Chem.
21
4477-4484
2013
Homo sapiens (P15428)
Manually annotated by BRENDA team
Castro-Sanchez, L.; Agra, N.; Llorente Izquierdo, C.; Motino, O.; Casado, M.; Bosca, L.; Martin-Sanz, P.
Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma
Int. J. Biochem. Cell Biol.
45
2501-2511
2013
Homo sapiens (P15428), Homo sapiens
Manually annotated by BRENDA team
Lu, D.; Han, C.; Wu, T.
15-hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome proliferator-activated receptor-gamma, SMAD2/3, and TAP63 proteins
J. Biol. Chem.
288
19484-19502
2013
Homo sapiens (P15428), Homo sapiens
Manually annotated by BRENDA team
Kim, H.J.; Lee, S.; Lee, H.Y.; Won, H.; Chang, S.H.; Nah, S.S.
15-hydroxyprostaglandin dehydrogenase is upregulated by hydroxychloroquine in rheumatoid arthritis fibroblast-like synoviocytes
Mol. Med. Rep.
12
4141-4148
2015
Homo sapiens (P15428), Homo sapiens
Manually annotated by BRENDA team
Kim, H.; Lee, H.; Lim, K.; Surh, Y.; Na, H.
15-Deoxy-DELTA12,14-prostaglandin J2 induces expression of 15-hydroxyprostaglandin dehydrogenase through Elk-1 activation in human breast cancer MDA-MB-231 cells
Mutat. Res.
768
6-15
2014
Homo sapiens (P15428), Homo sapiens
Manually annotated by BRENDA team
Sola-Villa, D.; Dilme, J.F.; Rodriguez, C.; Soto, B.; Vila, L.; Escudero, J.R.; Martinez-Gonzalez, J.; Camacho, M.
Expression and cellular localization of 15-hydroxy-prostaglandin-dehydrogenase in abdominal aortic aneurysm
PLoS ONE
10
e0136201
2015
Homo sapiens (P15428), Homo sapiens
Manually annotated by BRENDA team
Lee, J.; Zhong, X.; Lee, J.; Surh, Y.; Na, H.
15-Keto prostaglandin E2 induces heme oxygenase-1 expression through activation of Nrf2 in human colon epithelial CCD 841 CoN cells
Arch. Biochem. Biophys.
679
108162
2020
Homo sapiens (P15428), Homo sapiens
Manually annotated by BRENDA team
Yao, L.; Chen, W.; Song, K.; Han, C.; Gandhi, C.R.; Lim, K.; Wu, T.
15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury
PLoS ONE
12
e0176106
2017
Mus musculus (Q8VCC1), Mus musculus
Manually annotated by BRENDA team