1.1.1.141: 15-hydroxyprostaglandin dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about 15-hydroxyprostaglandin dehydrogenase (NAD+), go to the full flat file.

Reaction

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate
+
NAD+
=
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate
+
NADH
+
H+

Synonyms

11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase, 15-hydroxy prostaglandin dehydrogenase, 15-hydroxyprostaglandin dehydrogenase, 15-hydroxyprostaglandin-dehydrogenase, 15-hydroxyprostanoic dehydrogenase, 15-OH-PGDH, 15-PGDH, 15-prostaglandin dehydrogenase, dehydrogenase, 15-hydroxyprostaglandin, HPGD, NAD+ dependent 15-hydroxyprostaglandin dehydrogenase, NAD+ dependent PGDH, NAD+-15-hydroxy prostanoate oxidoreductase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I), NAD+-dependent 15-PGDH, NAD+-linked 15-hydroxyprostaglandin dehydrogenase, NAD-dependent 15-hydroxyprostaglandin dehydrogenase, NAD-specific 15-hydroxyprostaglandin dehydrogenase, PGDH, prostaglandin dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+)

KI Value

KI Value on EC 1.1.1.141 - 15-hydroxyprostaglandin dehydrogenase (NAD+)

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.26
15-ketoprostaglandin E1
-
substrate prostaglandin E1
0.02 - 0.031
15-Ketoprostaglandin E2
0.62
4-methoxybenzyl-2,4-thiazolidinedione
-
37°C, pH 7.5
0.017
4-methoxybenzylidene-2,4-thiazolidinedione
-
37°C, pH 7.5
0.0006
5-[4-((1-methyl)-cyclohexylmethoxy)benzylidene]-2,4-thiazolidenedione
-
37°C, pH 7.5
0.0022
5-[4-((1-methyl)-cyclohexylmethoxy)benzyl]-2,4-thiazolidenedione
-
37°C, pH 7.5
0.0012
5-[4-(benzoxy)benzylidene]-2,4-thiazolidenedione
-
37°C, pH 7.5
0.005
5-[4-(cyclohexylbutoxy)benzylidene]-2,4-thiazolidenedione
-
37°C, pH 7.5
0.00009
5-[4-(cyclohexylethoxy)benzylidene]-2,4-thiazolidenedione
-
37°C, pH 7.5
0.00027
5-[4-(cyclohexylmethoxy)benzylidene]-2,4-thiazolidenedione
-
37°C, pH 7.5
0.0009
5-[4-(cyclohexyloxy)benzylidene]-2,4-thiazolidenedione
-
37°C, pH 7.5
0.02 - 0.225
adenosine-5'-diphosphoribose
0.14
indomethacin
-
-
0.117 - 0.168
NAD+
0.0135 - 0.015
NADH
0.026 - 0.4
papaverine
0.0139
prostaglandin E1
-
-
0.0109
prostaglandin E2
-
-
0.0873
prostaglandin F2alpha
-
-
additional information
additional information
-