1.1.1.141: 15-hydroxyprostaglandin dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about 15-hydroxyprostaglandin dehydrogenase (NAD+), go to the full flat file.

Reaction

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate
+
NAD+
=
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate
+
NADH
+
H+

Synonyms

11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase, 15-hydroxy prostaglandin dehydrogenase, 15-hydroxy-prostaglandin-dehydrogenase, 15-hydroxyprostaglandin dehydrogenase, 15-hydroxyprostaglandin-dehydrogenase, 15-hydroxyprostanoic dehydrogenase, 15-OH-PGDH, 15-PGDH, 15-prostaglandin dehydrogenase, dehydrogenase, 15-hydroxyprostaglandin, HPGD, NAD+ dependent 15-hydroxyprostaglandin dehydrogenase, NAD+ dependent PGDH, NAD+-15-hydroxy prostanoate oxidoreductase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I), NAD+-dependent 15-PGDH, NAD+-linked 15-hydroxyprostaglandin dehydrogenase, NAD-dependent 15-hydroxyprostaglandin dehydrogenase, NAD-specific 15-hydroxyprostaglandin dehydrogenase, nicotinamide adenine dinucleotide-dependent 15-hydroxyprostaglandin dehydrogenase, PGDH, prostaglandin dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+)

Expression

Expression on EC 1.1.1.141 - 15-hydroxyprostaglandin dehydrogenase (NAD+)

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
15-deoxy-DELTA(12,14)-prostaglandin J2 upregulates the expression and the activity of the enzyme through reactive oxygen species-mediated activation of extracellular-signal related kinase1/2 and subsequently Elk-1 in human breast cancer MDA-MB-231 cells
-
15-hydroxyprostaglandin dehydrogenase is upregulated by hydroxychloroquine in rheumatoid arthritis fibroblast-like synoviocytes
-
15-PGDH is overexpressed in malignant ovarian tissue
-
enzyme mRNA levels are significantly higher in aorta samples from patients undergoing abdominal aortic aneurysm repair than in those from healthy multiorgan donors
-
interleukin 4 induces up-regulation of 15-PGDH expression in A549 cells as well as in other lung cancer cell lines
-
levels enzyme mRNA increase significantly reaching the highest mRNA levels during the postimplantation period of pregnancy
PDGH shows little expression in the myometrium; PGDH messenger RNA (mRNA) abundance decreases significantly in the visceral yolk sac membrane and the amnion throughout the last third of pregnancy
-
PGDH protein is highly expressed in the endometrial epithelium
-
PGDH protein is robustly expressed in the visceral yolk sac epithelium and mesoderm, correlating strongly with PGDH mRNA levels
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the enzyme is downregulated in human hepatoma cells with a high cyclooxygenase-2 expression
-