1.1.1.138: mannitol 2-dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about mannitol 2-dehydrogenase (NADP+), go to the full flat file.

Reaction

D-mannitol
+
NADP+
=
D-fructose
+
NADPH
+
H+

Synonyms

Cla h 8, Cla h 8 allergen, D-mannitol 2-dehydrogenase, D-mannitol dehydrogenase, D-mannitol dehydrogenase, NADP-dependent, LRMDH, LXR1, MAD1p, Mannitol 2-dehydrogenase [NADP+], mannitol dehydrogenase, mannitol dehydrogenase (NADP+), mannitol dehydrogenase (nicotinamide dinucleotide phosphate), mannitol dehydrogenase 1, MDH, More, MtDH, NADP-dependent mannitol dehydrogenase, NADP-dependent MtDH, NADP-mannitol dehydrogenase, PIG8p, PSLDR, TbMDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.138 mannitol 2-dehydrogenase (NADP+)

Reference

Reference on EC 1.1.1.138 - mannitol 2-dehydrogenase (NADP+)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Grant, C.R.; Rees, T.A.
Sorbitol metabolism by apple seedlings
Phytochemistry
20
1505-1511
1981
Laminaria digitata
-
Manually annotated by BRENDA team
Singh, M.; Scrutton, N.S.; Scrutton, M.C.
NADPH generation in Aspergillus nidulans: is the mannitol cycle involved?
J. Gen. Microbiol.
134
643-654
1988
Aspergillus nidulans
Manually annotated by BRENDA team
Hult, K.; Veide, A.; Gatenbeck, S.
The distribution of the NADPH regenerating mannitol cycle among fungal species
Arch. Microbiol.
128
253-255
1980
Alternaria alternata, Botrytis cinerea, Ceratocystis multiannulata, Cladosporium cladosporioides, Fusarium graminearum, Neurospora crassa, Penicillium glabrum, Talaromyces islandicus, Thermomyces lanuginosus
Manually annotated by BRENDA team
Stoop, J.M.H.; Mooibroek, H.
Cloning and characterization of NADP-dependent dehydrogenase cDNA from the button mushroom, Agaricus bisporus, and its expression in response to NaCl stress
Appl. Environ. Microbiol.
64
4689-4696
1998
Agaricus bisporus
Manually annotated by BRENDA team
Adachi, O.; Toyama, H.; Matsushita, K.
Crystalline NADP-dependent D-mannitol dehydrogenase from Gluconobacter suboxydans
Biosci. Biotechnol. Biochem.
63
402-407
1999
Gluconobacter oxydans, Gluconobacter oxydans IFO 12528
Manually annotated by BRENDA team
Kulkarni, R.K.
Mannitol metabolism in Lentinus edodes, the shiitake mushroom
Appl. Environ. Microbiol.
56
250-253
1990
Lentinula edodes
Manually annotated by BRENDA team
Martin, F.; Canet, D.; Marchal, J.P.
13C Nuclear magnetic resonance study of mannitol cycle and trehalose synthesis during glucose utilization by the ectomycorrhizal ascomycete Cenococcum graniforme
Plant Physiol.
77
499-502
1985
Cenococcum graniforme
Manually annotated by BRENDA team
Morton, N.; Dickerson, A.G.; Hammond, J.B.W.
Mannitol metabolism in Agaricus bisporus: Purification and properties of mannitol dehydrogenase
J. Gen. Microbiol.
131
2885-2890
1985
Agaricus bisporus
-
Manually annotated by BRENDA team
Boutelje, J.; Hult, K.; Gatenbeck, S.
Mannitol dehydrogenase from industrial waste mycelium of Penicillium chrysogenum. Purification, properties and possible use in cofactor regenerating systems in vitro
Eur. J. Appl. Microbiol. Biotechnol.
17
7-12
1983
Penicillium chrysogenum
-
Manually annotated by BRENDA team
Niehaus, W.G.; Dilts, R.P.
Purification and characterization of mannitol dehydrogenase from Aspergillus parasiticus
J. Bacteriol.
151
243-250
1982
Aspergillus parasiticus
Manually annotated by BRENDA team
Clancy, F.G.; Coffey, M.D.
Polyol dehydrogenases in the rust fungus, Melampsora lini (Ehrenb.) Lev.
J. Gen. Microbiol.
120
85-88
1980
Melampsora lini
-
Manually annotated by BRENDA team
Ruffner, H.P.; Rast, D.; Tobler, H.; Karesch, H.
Purification and properties of mannitol dehydrogenase from Agaricus bisporus sporocarps
Phytochemistry
17
865-868
1978
Agaricus bisporus
-
Manually annotated by BRENDA team
Sasajima, K.; Isono, M.
Polyol dehydrogenases in the soluble fraction of Acetobacter melanogenum
Agric. Biol. Chem.
32
161-169
1968
Gluconobacter oxydans
-
Manually annotated by BRENDA team
Strobel, G.A.; Kosuge, T.
Polyol metabolism in Diplodia viticola Desm.
Arch. Biochem. Biophys.
109
622-626
1965
Diplodia viticola Desm.
Manually annotated by BRENDA team
Edmundowicz, J.M.; Wriston, J.C.
Mannitol dehydrogenase from Agaricus campestris
J. Biol. Chem.
238
3539-3541
1963
Agaricus campestris
Manually annotated by BRENDA team
Hammond, J.B.W.
Carbohydrate metabolism in Agaricus bisporus: Oxidative pathways in mycelium and sporophore
J. Gen. Microbiol.
102
245-248
1977
Agaricus bisporus
-
Manually annotated by BRENDA team
Horer, S.; Stoop, J.; Mooibroek, H.; Baumann, U.; Sassoon, J.
The crystallographic structure of the mannitol 2-dehydrogenase NADP+ binary complex from Agaricus bisporus
J. Biol. Chem.
276
27555-27561
2001
Agaricus bisporus
Manually annotated by BRENDA team
Sassoon, J.; Horer, S.; Stoop, J.; Mooibroek, H.; Baumann, U.
Crystallization and preliminary crystallographic analysis of mannitol dehydrogenase (MtDH) from the common mushroom Agaricus bisporus
Acta Crystallogr. Sect. D
57
711-713
2001
Agaricus bisporus
Manually annotated by BRENDA team
Lee, J.K.; Koo, B.S.; Kim, S.Y.; Hyun, H.H.
Purification and characterization of a novel mannitol dehydrogenase from a newly isolated strain of Candida magnoliae
Appl. Environ. Microbiol.
69
4438-4447
2003
Candida magnoliae
Manually annotated by BRENDA team
Lee, J.K.; Song, J.Y.; Kim, S.Y.
Controlling substrate concentration in fed-batch Candida magnoliae culture increases mannitol production
Biotechnol. Prog.
19
768-775
2003
Candida magnoliae
Manually annotated by BRENDA team
Saha, B.C.
Purification and characterization of a novel mannitol dehydrogenase from Lactobacillus intermedius
Biotechnol. Prog.
20
537-542
2004
Lactobacillus intermedius
Manually annotated by BRENDA team
Klimacek, M.; Kavanagh, K.L.; Wilson, D.K.; Nidetzky, B.
Pseudomonas fluorescens mannitol 2-dehydrogenase and the family of polyol-specific long-chain dehydrogenases/reductases: sequence-based classification and analysis of structure-function relationships
Chem. Biol. Interact.
143-144
559-582
2003
Pseudomonas fluorescens
Manually annotated by BRENDA team
Trail, F.; Xu, H.
Purification and characterization of mannitol dehydrogenase and identification of the corresponding cDNA from the head blight fungus, Gibberella zeae (Fusarium graminearum)
Phytochemistry
61
791-796
2002
Fusarium graminearum
Manually annotated by BRENDA team
Sasaki, Y.; Laivenieks, M.; Zeikus, J.G.
Lactobacillus reuteri ATCC 53608 mdh gene cloning and recombinant mannitol dehydrogenase characterization
Appl. Microbiol. Biotechnol.
68
36-41
2005
Lactobacillus reuteri
Manually annotated by BRENDA team
Schneider, P.B.; Denk, U.; Breitenbach, M.; Richter, K.; Schmid-Grendelmeier, P.; Nobbe, S.; Himly, M.; Mari, A.; Ebner, C.; Simon-Nobbe, B.
Alternaria alternata NADP-dependent mannitol dehydrogenase is an important fungal allergen
Clin. Exp. Allergy
36
1513-1524
2006
Alternaria alternata, Alternaria alternata (P0C0Y4)
Manually annotated by BRENDA team
Simon-Nobbe, B.; Denk, U.; Schneider, P.B.; Radauer, C.; Teige, M.; Crameri, R.; Hawranek, T.; Lang, R.; Richter, K.; Schmid-Grendelmeier, P.; Nobbe, S.; Hartl, A.; Breitenbach, M.
NADP-dependent mannitol dehydrogenase, a major allergen of Cladosporium herbarum
J. Biol. Chem.
281
16354-16360
2006
Cladosporium herbarum, Cladosporium herbarum (P0C0Y5)
Manually annotated by BRENDA team
Voegele, R.T.; Hahn, M.; Lohaus, G.; Link, T.; Heiser, I.; Mendgen, K.
Possible roles for mannitol and mannitol dehydrogenase in the biotrophic plant pathogen Uromyces fabae
Plant Physiol.
137
190-198
2005
Uromyces viciae-fabae
Manually annotated by BRENDA team
Lee, J.; Oh, D.; Song, H.; Kim, I.
Ca2+ and Cu2+ supplementation increases mannitol production by Candida magnoliae
Biotechnol. Lett.
29
291-294
2007
Candida magnoliae, Candida magnoliae HH-01
Manually annotated by BRENDA team
Bubner, P.; Klimacek, M.; Nidetzky, B.
Structure-guided engineering of the coenzyme specificity of Pseudomonas fluorescens mannitol 2-dehydrogenase to enable efficient utilization of NAD(H) and NADP(H)
FEBS Lett.
582
233-237
2008
Pseudomonas fluorescens
Manually annotated by BRENDA team
Velez, H.; Glassbrook, N.J.; Daub, M.E.
Mannitol biosynthesis is required for plant pathogenicity by Alternaria alternata
FEMS Microbiol. Lett.
285
122-129
2008
Alternaria alternata, Alternaria alternata A5
Manually annotated by BRENDA team
Ceccaroli, P.; Saltarelli, R.; Guescini, M.; Polidori, E.; Buffalini, M.; Menotta, M.; Pierleoni, R.; Barbieri, E.; Stocchi, V.
Identification and characterization of the Tuber borchii D-mannitol dehydrogenase which defines a new subfamily within the polyol-specific medium chain dehydrogenases
Fungal Genet. Biol.
44
965-978
2007
Tuber borchii (Q1ACW3), Tuber borchii
Manually annotated by BRENDA team
Metz, B.; de Vries, R.P.; Polak, S.; Seidl, V.; Seiboth, B.
The Hypocrea jecorina (syn. Trichoderma reesei) lxr1 gene encodes a D-mannitol dehydrogenase and is not involved in L-arabinose catabolism
FEBS Lett.
583
1309-1313
2009
Trichoderma reesei, Trichoderma reesei QM9414
Manually annotated by BRENDA team
Nuess, D.; Goettig, P.; Magler, I.; Denk, U.; Breitenbach, M.; Schneider, P.B.; Brandstetter, H.; Simon-Nobbe, B.
Crystal structure of the NADP-dependent mannitol dehydrogenase from Cladosporium herbarum: Implications for oligomerisation and catalysis
Biochimie
92
985-993
2010
Cladosporium herbarum, Cladosporium herbarum (P0C0Y5)
Manually annotated by BRENDA team