1.1.1.138: mannitol 2-dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about mannitol 2-dehydrogenase (NADP+), go to the full flat file.

Reaction

D-mannitol
+
NADP+
=
D-fructose
+
NADPH
+
H+

Synonyms

Cla h 8, Cla h 8 allergen, D-mannitol 2-dehydrogenase, D-mannitol dehydrogenase, D-mannitol dehydrogenase, NADP-dependent, LRMDH, LXR1, MAD1p, Mannitol 2-dehydrogenase [NADP+], mannitol dehydrogenase, mannitol dehydrogenase (NADP+), mannitol dehydrogenase (nicotinamide dinucleotide phosphate), mannitol dehydrogenase 1, MDH, More, MtDH, NADP-dependent mannitol dehydrogenase, NADP-dependent MtDH, NADP-mannitol dehydrogenase, PIG8p, PSLDR, TbMDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.138 mannitol 2-dehydrogenase (NADP+)

Inhibitors

Inhibitors on EC 1.1.1.138 - mannitol 2-dehydrogenase (NADP+)

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
inhibits 96% at 4 mM, reduction reaction
2-mercaptoethanol
Ca2+
inhibits 21% at 1 mM, reduction reaction
D-fructose
D-mannitol
dithiothreitol
-
0.5 mM, complete inhibition
DTT
inhibits 89% at 0.5 mM, reduction reaction
Fe2+
-
86% inhibition at 1 mM
glutathione
-
0.5 mM, complete inhibition
KCl
-
half Vmax/Km at less than 0.1 M due to general ionic strength effect
KNO3
-
half Vmax/Km at less than 0.1 M due to general ionic strength effect
L-cysteine
-
0.5 mM, complete inhibition
Mg2+
inhibits 19% at 1 mM, reduction reaction
NaCl
-
half Vmax/Km at less than 0.1 M due to general ionic strength effect
NADP+
NADPH
p-chloromercuribenzoate
-
0.2 mM, complete inhibition
Sn2+
-
29% inhibition at 1 mM
additional information
-