1.1.1.135: GDP-6-deoxy-D-talose 4-dehydrogenase

This is an abbreviated version, for detailed information about GDP-6-deoxy-D-talose 4-dehydrogenase, go to the full flat file.

Reaction

GDP-6-deoxy-alpha-D-talose
+
NAD(P)+
=
GDP-4-dehydro-alpha-D-rhamnose
+
NAD(P)H
+
H+

Synonyms

GDP-4-keto-rhamnose reductase, GDP-6-deoxy-D-talose dehydrogenase, guanosine diphospho-6-deoxy-D-talose dehydrogenase, HADH2

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.135 GDP-6-deoxy-D-talose 4-dehydrogenase

Disease

Disease on EC 1.1.1.135 - GDP-6-deoxy-D-talose 4-dehydrogenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
3-hydroxy-2-methylbutyryl-coa dehydrogenase deficiency
2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency is caused by mutations in the HADH2 gene.
HSD17B10 replaces HADH2 as the approved designation for the gene mutated in 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency.
The reduced expression of the HADH2 protein causes X-linked mental retardation, choreoathetosis, and abnormal behavior.
Mental Retardation, X-Linked
The reduced expression of the HADH2 protein causes X-linked mental retardation, choreoathetosis, and abnormal behavior.
Neurodegenerative Diseases
The reduced expression of the HADH2 protein causes X-linked mental retardation, choreoathetosis, and abnormal behavior.