1.1.1.133: dTDP-4-dehydrorhamnose reductase

This is an abbreviated version, for detailed information about dTDP-4-dehydrorhamnose reductase, go to the full flat file.

Reaction

dTDP-beta-L-rhamnose
+
NADP+
=
dTDP-4-dehydro-beta-L-rhamnose
+
NADPH
+
H+

Synonyms

4-ketoreductase, bifunctional UDP-4-keto-6-deoxy-D-glucose epimerase/reductase, dTDP-4-dehydrorhamnose reductase, dTDP-4-keto-L-rhamnose reductase, dTDP-4-keto-rhamnose reductase, dTDP-4-ketorhamnose reductase, dTDP-6-deoxy-L-lyxo-4-hexulose reductase, dTDP-6-deoxy-L-mannose dehydrogenase, dTDP-L-rhamnose synthetase, RmlD, TDP-4-keto-rhamnose reductase, TDP-4-ketorhamnose reductase, thymidine diphosphate-4-dehydrorhamnose reductase, thymidine diphosphate-6-deoxy-L-talose, thymidine diphospho-4-ketorhamnose reductase, UGER

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.133 dTDP-4-dehydrorhamnose reductase

Reference

Reference on EC 1.1.1.133 - dTDP-4-dehydrorhamnose reductase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Melo, A.; Glaser, L.
The mechanism of 6-deoxyhexose synthesis. II. Conversion of deoxythymidine diphosphate 4-keto-6-deoxy-D-glucose to deoxythymidine diphosphate L-rhamnose
J. Biol. Chem.
243
1475-1478
1968
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Giraud, M.F.; McMiken, H.J.; Leonard, G.A.; Messner, P.; Whitfield, C.; Naismith, J.H.
Overexpression, purification, crystallization and preliminary structural study of dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD), the fourth enzyme of the dTDP-L-rhamnose synthesis pathway, from Salmonella enterica serovar typhimurium
Acta Crystallogr. Sect. D
55
2043-2046
1999
Escherichia coli, Escherichia coli K12, Salmonella enterica, Shigella flexneri, Streptomyces mutans, Xanthomonas campestris
-
Manually annotated by BRENDA team
Nakano, Y.; Suzuki, N.; Yoshida, Y.; Nezu, T.; Yamashita, Y.; Koga, T.
Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans
J. Biol. Chem.
275
6806-6812
2000
Aggregatibacter actinomycetemcomitans, Escherichia coli, Escherichia coli O45
Manually annotated by BRENDA team
Graninger, M.; Nidetzky, B.; Heinrichs, D.E.; Whitfield, C.; Messner, P.
Characterization of dTDP-4-dehydrorhamnose 3,5-epimerase and dTDP-4-dehydrorhamnose reductase, required for dTDP-L-rhamnose biosynthesis in Salmonella enterica serovar typhimurium LT2
J. Biol. Chem.
274
25069-25077
1999
Salmonella enterica
Manually annotated by BRENDA team
Watt, G.; Leoff, C.; Harper, A.D.; Bar-Peled, M.
A bifunctional 3,5-epimerase/4-keto reductase for nucleotide-rhamnose synthesis in Arabidopsis
Plant Physiol.
134
1337-1346
2004
Arabidopsis thaliana (Q9LQ04)
Manually annotated by BRENDA team
Blankenfeldt, W.; Kerr, I.D.; Giraud, M.F.; McMiken, H.J.; Leonard, G.; Whitfield, C.; Messner, P.; Graninger, M.; Naismith, J.H.
Variation on a theme of SDR: dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) shows a new Mg2+-dependent dimerization mode
Structure
10
773-786
2002
Salmonella enterica
Manually annotated by BRENDA team
Elling, L.; Rupprath, C.; Gunther, N.; Romer, U.; Verseck, S.; Weingarten, P.; Drager, G.; Kirschning, A.; Piepersberg, W.
An enzyme module system for the synthesis of dTDP-activated deoxysugars from dTMP and sucrose
ChemBioChem
6
1423-1430
2005
Salmonella enterica
Manually annotated by BRENDA team
Kang, Y.; Yang, Y.; Lee, K.; Lee, S.; Sohng, J.K.; Lee, H.C.; Liou, K.; Kim, B.
Preparative synthesis of dTDP-L-rhamnose through combined enzymatic pathways
Biotechnol. Bioeng.
93
21-27
2005
Mesorhizobium loti
Manually annotated by BRENDA team
Parakkottil Chothi, M.; Duncan, G.; Armirotti, A.; Abergel, C.; Gurnon, J.; Van Etten, J.; Bernardi, C.; Damonte, G.; Tonetti, M.
Identification of an L-rhamnose synthetic pathway in two nucleocytoplasmic large DNA viruses
J. Virol.
84
8829-8838
2010
Acanthamoeba polyphaga Mimivirus (E3VXL5)
Manually annotated by BRENDA team
Wang, Y.; Hess, T.N.; Jones, V.; Zhou, J.Z.; McNeil, M.R.; Andrew McCammon, J.
Novel inhibitors of Mycobacterium tuberculosis dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) identified by virtual screening
Bioorg. Med. Chem. Lett.
21
7064-7067
2011
Mycobacterium tuberculosis
Manually annotated by BRENDA team