1.1.1.127: 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase

This is an abbreviated version, for detailed information about 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase, go to the full flat file.

Reaction

2-dehydro-3-deoxy-D-gluconate
+
NAD+
=
(4S)-4,6-dihydroxy-2,5-dioxohexanoate
+
NADH
+
H+

Synonyms

2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase, 2-keto-3-deoxy-D-gluconate dehydrogenase, 2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase, 2-keto-3-deoxygluconate 5-dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.127 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase

Reaction

Reaction on EC 1.1.1.127 - 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase

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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-dehydro-3-deoxy-D-gluconate + NAD+ = (4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH + H+
show the reaction diagram
The enzyme from Pseudomas acts equally well on NAD+ or NADP+, while that from Erwinia chrysanthemi and E. coli is more specific for NAD+
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