1.1.1.123: sorbose 5-dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about sorbose 5-dehydrogenase (NADP+), go to the full flat file.

Reaction

L-sorbose
+
NADP+
=
5-dehydro-D-fructose
+
NADPH
+
H+

Synonyms

5-keto-D-fructose reductase, 5-ketofructose reductase, reduced nicotinamide adenine dinucleotide phosphate-linked reductase, sorbose (nicotinamide adenine dinucleotide phosphate) dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.123 sorbose 5-dehydrogenase (NADP+)

Engineering

Engineering on EC 1.1.1.123 - sorbose 5-dehydrogenase (NADP+)

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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
addition of Arg and loss of Asp decrease the electric potential of the adenosine ribose-binding-pocket, creating an environment favorable for NADPH-binding, the replacement of an Asp with an Ala and the adjacent Leu with an Arg change the potential