1.1.1.122: D-threo-aldose 1-dehydrogenase

This is an abbreviated version, for detailed information about D-threo-aldose 1-dehydrogenase, go to the full flat file.

Reaction

a D-threo-aldose
+
NAD+
=
a D-threo-aldono-1,5-lactone
+
NADH
+
H+

Synonyms

(2S,3R)-aldose dehydrogenase, FDH, L-fucose (D-arabinose) dehydrogenase, L-fucose dehydrogenase, Sso1300

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.122 D-threo-aldose 1-dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.122 - D-threo-aldose 1-dehydrogenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-Amino-3-deoxy-D-arabinose
-
-
ADP
Ovis aries aries
-
slight inhibition
ATP
Ovis aries aries
-
slight inhibition
Cd2+
-
inhibitory
D-arabinose
-
competitive inhibition of L-fucose oxidation at 2.5 mM
D-galactose
-
79% inhibition of L-glucose oxidation
D-glucose
-
competitive inhibition of L-glucose oxidation, Ki: 130 mM
Heavy metal ions
-
strong inhibition
-
iodoacetic acid
-
10% inhibition at 1 mM
L-arabinose
-
74% inhibition of L-glucose oxidation
L-rhamnose
-
74% inhibition of L-glucose oxidation
N-ethylmaleimide
-
strong inhibition at 0.1 mM
NADH
Ovis aries aries
-
Ki: 0.04 mM
p-chloromercuribenzoate
p-hydroxymercuribenzoate
-
20% loss of activity, saturated
sodium iodoacetate
-
20% loss of activity at 20 mM, pH 8.0
thiol reagents
-
strong inhibition
Zn2+
-
40% inhibition