1.1.1.118: glucose 1-dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about glucose 1-dehydrogenase (NAD+), go to the full flat file.

Reaction

D-glucose
+
NAD+
=
D-glucono-1,5-lactone
+
NADH
+
H+

Synonyms

D-aldohexose dehydrogenase, D-glucose:NAD oxidoreductase, dehydrogenase, glucose (nicotinamide adenine dinucleotide), GDH, GDH1, glucose dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.118 glucose 1-dehydrogenase (NAD+)

Inhibitors

Inhibitors on EC 1.1.1.118 - glucose 1-dehydrogenase (NAD+)

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
rapid inactivation at 1 mM
5,5'-dithiobis-(2-nitrobenzoic acid)
-
-
EDTA
-
5% residual activity at 50 mM, addition of Mg2+ in excess restored the initial activity
Guanidinium chloride
-
rapid inactivation at 4 M
N-ethylmaleimide
-
-
NADPH
-
inhibits the NAD+-dependent carbohydrate oxidations in a competitive manner with respect to NAD+
tetrahydrofuran
-
-
additional information
-
D-alactose, D-mannose and D-ribose, in concentrations as high as 0.04 mM do not inhibit glucose oxidation by NAD+
-