1.1.1.108: carnitine 3-dehydrogenase

This is an abbreviated version, for detailed information about carnitine 3-dehydrogenase, go to the full flat file.

Reaction

carnitine
+
NAD+
=
3-dehydrocarnitine
+
NADH
+
H+

Synonyms

Cdh, CDHA, CDHB, CDHC, CDHR, L-(-)-carnitine dehydrogenase, L-carnitine dehydrogenase, L-CDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.108 carnitine 3-dehydrogenase

Engineering

Engineering on EC 1.1.1.108 - carnitine 3-dehydrogenase

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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A185G
-
the mutant shows reduced activity compared to the wild type enzyme
S220G/F221A
-
the mutant shows reduced activity compared to the wild type enzyme
V187I/G188A
-
inactive
Y140A
-
inactive
Y140C
-
the mutant shows reduced activity compared to the wild type enzyme
Y140D
-
inactive
Y140F
-
the mutant shows reduced activity compared to the wild type enzyme
Y140G
-
inactive
Y140H
-
inactive
Y140K
-
inactive
Y140N
-
inactive
Y140S
-
the mutant shows reduced activity compared to the wild type enzyme
Y140W
-
the mutant shows reduced activity compared to the wild type enzyme
D298A
-
inactive
E185A
-
the mutant shows reduced activity compared to the wild type enzyme
E196A
-
inactive
E201A
-
the mutant shows reduced activity compared to the wild type enzyme
F143A
-
the mutant shows reduced activity compared to the wild type enzyme
F143C
-
the mutant shows reduced activity compared to the wild type enzyme
F143D
-
inactive
F143G
-
the mutant shows reduced activity compared to the wild type enzyme
F143H
-
the mutant shows reduced activity compared to the wild type enzyme
F143K
-
the mutant shows reduced activity compared to the wild type enzyme
F143N
-
the mutant shows reduced activity compared to the wild type enzyme
F143S
-
the mutant shows reduced activity compared to the wild type enzyme
F143W
-
inactive
F143Y
-
the mutant shows reduced activity compared to the wild type enzyme
F189A
-
the mutant shows reduced activity compared to the wild type enzyme
F234A
-
the mutant shows reduced activity compared to the wild type enzyme
F249A
-
inactive
F253A
-
inactive
G188A
-
the mutant shows reduced activity compared to the wild type enzyme
G233S/A224F
-
the mutant shows reduced activity compared to the wild type enzyme
I190V/A191G
-
the mutant shows reduced activity compared to the wild type enzyme
M231A
-
the mutant shows reduced activity compared to the wild type enzyme
M246A
-
the mutant shows reduced activity compared to the wild type enzyme
N144A
-
the mutant shows reduced activity compared to the wild type enzyme
Q252A
-
the mutant shows reduced activity compared to the wild type enzyme
R193A
-
inactive
R200A
-
the mutant shows reduced activity compared to the wild type enzyme
R297A
-
the mutant shows reduced activity compared to the wild type enzyme
S117A
-
the mutant shows reduced activity compared to the wild type enzyme
S120A
-
the mutant shows reduced activity compared to the wild type enzyme
T262A
-
the mutant shows reduced activity compared to the wild type enzyme
W199A
-
inactive
W228A
-
the mutant shows reduced activity compared to the wild type enzyme
W261A
-
inactive
Y147A
-
the mutant shows reduced activity compared to the wild type enzyme
Y237A
-
the mutant shows reduced activity compared to the wild type enzyme
additional information