1.1.1.106: pantoate 4-dehydrogenase

This is an abbreviated version, for detailed information about pantoate 4-dehydrogenase, go to the full flat file.

Reaction

(R)-pantoate
+
NAD+
=
(R)-4-Dehydropantoate
+
NADH
+
H+

Synonyms

D-pantoate:NAD+ 4-oxidoreductase, pantoate dehydrogenase, pantothenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.106 pantoate 4-dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.106 - pantoate 4-dehydrogenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5,5'-dithiobis(2-nitrobenzoic acid)
-
1 mM, 50% inhibition after 4.6 min, half-inactivation time increases to 7.0 min in the presence of 20 mM D-pantoate
iodacetic acid
-
1 mM, 50% inhibition after 14 min, half-inactivation time increases to 29.0 min in the presence of 20 mM D-pantoate, 70% inhibition within 50 min at pH 7.2, 20 mM pantoate decreases inactivation from 70 to 30%
p-chloromercuribenzoate
-
0.1 mM, 85% inhibition after 15 min, 200 mM 2-mercaptoethanol restores 70% of enzyme activity within 10 min, 20 mM D-pantoate and 1 mM NAD+ prevent inactivation when added simultaneously
Phenylglyoxal
-
5.3 mM, 70% inhibition in borate buffer, 92% inhibition in NaHCO3 buffer within 10 min, complete inactivation after prolonged incubation with phenylglyoxal, NAD+ and D-pantoate increase half-inactivation time from 6 min without substrates to 40 and 17 min respectively