1.1.1.105: all-trans-retinol dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about all-trans-retinol dehydrogenase (NAD+), go to the full flat file.

Reaction

all-trans-retinol-[cellular-retinol-binding-protein]
+
NAD+
=
all-trans-retinal-[cellular-retinol-binding-protein]
+
NADH
+
H+

Synonyms

all-trans retinol dehydrogenase, all-trans-retinol dehydrogenase, dehydrogenase, retinol, DHRS9, epidermal retinol dehydrogenase 2, LOC100185899, MDR, microsomal retinol dehydrogenase, mRDH1, NAD+-dependent retinoid-active short-chain dehydrogenase/reductase, P32, RDH-E2, RDH-like SDR, Rdh1, RDH10, RDH10a, RDH10b, RDH10c, RDH12, RDH16, RDH2, RDH7, RDH8, RDHE2, RDHE2S, RDHL, retinal reductase, retinene reductase, retinoid dehydrogenase/reductase, retinol dehydrogenase (vitamin A1), retinol dehydrogenase 10, retinol dehydrogenase 12, retinol dehydrogenase 2, retinol dehydrogenase 4, retinol dehydrogenase epidermal 2-similar, RL-HSD, RoDH-4, RoDH-like 3alpha-hydroxysteroid dehydrogenase, RoDH4, SDR16C5, SDR16C6, XP_2120364

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.105 all-trans-retinol dehydrogenase (NAD+)

Substrates Products

Substrates Products on EC 1.1.1.105 - all-trans-retinol dehydrogenase (NAD+)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
13-cis-retinol + NAD+
13-cis-retinal + NADH + H+
show the reaction diagram
3,4-didehydroretinol + NAD+
3,4-didehydroretinal + NADH
show the reaction diagram
-
60% of the efficiency against all-trans-retinol
-
-
?
5alpha-androstan-3alpha-ol-17-one + NAD+
? + NADH
show the reaction diagram
-
-
-
-
-
9-cis-retinol + NAD+
9-cis-retinal + NADH + H+
show the reaction diagram
higher activity with all-trans-retinol versus 9-cis-retinol
-
-
?
all-trans retinal + NADH + H+
all-trans retinol + NAD+
show the reaction diagram
26.8% of the activity with butan-1-ol
-
-
?
all-trans retinal + NADH + H+
all-trans-retinol + NAD+
show the reaction diagram
all-trans-retinal + NAD(P)H + H+
all-trans-retinol + NAD(P)+
show the reaction diagram
all-trans-retinal + NADH + H+
all-trans-retinol + NAD+
show the reaction diagram
all-trans-retinaldehyde + NADH + H+
?
show the reaction diagram
-
-
-
?
all-trans-retinol + NAD+
all-trans-retinal + NADH
show the reaction diagram
all-trans-retinol + NAD+
all-trans-retinal + NADH + H+
show the reaction diagram
all-trans-retinol + NADP+
all-trans-retinal + NADPH + H+
show the reaction diagram
exhibits a strong preference for NAD+/NADH as cofactors. Activity with NAD+ is about 10fold higher than activity in presence of NADP+
-
-
r
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
show the reaction diagram
androsterone + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
retinal + NAD(P)H
retinol + NAD(P)+
show the reaction diagram
-
-
-
ir
retinal + NADH
retinol + NAD+
show the reaction diagram
retinal + NADH + H+
retinol + NAD+
show the reaction diagram
-
-
-
r
retinal + NADPH + H+
retinol + NADP+
show the reaction diagram
retinol + NAD+
retinal + NADH
show the reaction diagram
retinol + NADP+
retinal + NADPH
show the reaction diagram
-
-
-
-
?
retinol bound to cellular retinol binding protein + NAD+
retinal bound to cellular retinol binding protein + NADH
show the reaction diagram
-
-
-
-
-
additional information
?
-