1.1.1.105: all-trans-retinol dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about all-trans-retinol dehydrogenase (NAD+), go to the full flat file.

Reaction

all-trans-retinol-[cellular-retinol-binding-protein]
+
NAD+
=
all-trans-retinal-[cellular-retinol-binding-protein]
+
NADH
+
H+

Synonyms

all-trans retinol dehydrogenase, all-trans-retinol dehydrogenase, dehydrogenase, retinol, DHRS9, epidermal retinol dehydrogenase 2, LOC100185899, MDR, microsomal retinol dehydrogenase, mRDH1, NAD+-dependent retinoid-active short-chain dehydrogenase/reductase, P32, RDH-E2, RDH-like SDR, Rdh1, RDH10, RDH10a, RDH10b, RDH10c, RDH12, RDH16, RDH2, RDH7, RDH8, RDHE2, RDHE2S, RDHL, retinal reductase, retinene reductase, retinoid dehydrogenase/reductase, retinol dehydrogenase (vitamin A1), retinol dehydrogenase 10, retinol dehydrogenase 12, retinol dehydrogenase 2, retinol dehydrogenase 4, retinol dehydrogenase epidermal 2-similar, RL-HSD, RoDH-4, RoDH-like 3alpha-hydroxysteroid dehydrogenase, RoDH4, SDR16C5, SDR16C6, XP_2120364

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.105 all-trans-retinol dehydrogenase (NAD+)

KM Value

KM Value on EC 1.1.1.105 - all-trans-retinol dehydrogenase (NAD+)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0022
9-cis-retinol
-
pH 8, 37C
0.00046
all-trans retinal
-
pH not specified in the publication, temperature not specified in the publication
0.0087 - 0.57
all-trans-retinal
0.000039 - 0.0041
all-trans-retinol
0.0002
androsterone
-
pH 7.3, 37C
0.00024 - 0.036
NAD+
0.011 - 0.224
NADH
0.027
NADP+
-
wild type enzyme, in 100 mM sodium phosphate, pH 7.4
0.0015
NADPH
-
wild type enzyme, in 100 mM sodium phosphate, pH 7.4
0.12
retinol
-
-
0.0027
retinol bound to cellular retinol binding protein
-
pH 7.3, 37C
-
additional information
additional information
-
possible Michaelis-Menten relationship between RDH10 and holo-CRBP1
-