1.1.1.105: all-trans-retinol dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about all-trans-retinol dehydrogenase (NAD+), go to the full flat file.

Reaction

all-trans-retinol-[cellular-retinol-binding-protein]
+
NAD+
=
all-trans-retinal-[cellular-retinol-binding-protein]
+
NADH
+
H+

Synonyms

all-trans retinol dehydrogenase, all-trans-retinol dehydrogenase, dehydrogenase, retinol, DHRS9, epidermal retinol dehydrogenase 2, LOC100185899, MDR, microsomal retinol dehydrogenase, mRDH1, NAD+-dependent retinoid-active short-chain dehydrogenase/reductase, P32, RDH-E2, RDH-like SDR, Rdh1, RDH10, RDH10a, RDH10b, RDH10c, RDH12, RDH16, RDH2, RDH7, RDH8, RDHE2, RDHE2S, RDHL, retinal reductase, retinene reductase, retinoid dehydrogenase/reductase, retinol dehydrogenase (vitamin A1), retinol dehydrogenase 10, retinol dehydrogenase 12, retinol dehydrogenase 2, retinol dehydrogenase 4, retinol dehydrogenase epidermal 2-similar, RL-HSD, RoDH-4, RoDH-like 3alpha-hydroxysteroid dehydrogenase, RoDH4, SDR16C5, SDR16C6, XP_2120364

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.105 all-trans-retinol dehydrogenase (NAD+)

Expression

Expression on EC 1.1.1.105 - all-trans-retinol dehydrogenase (NAD+)

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression of the native RDHE2 is downregulated in the presence of elevated levels of all-trans-retinoic acid
-
insulin decreases Rdh10 and Rdh16 mRNA in HepG2 cells incubated in serum-free medium by inhibiting transcription and destabilizing mRNA; insulin decreases Rdh10 and Rdh16 mRNA in HepG2 cells incubated in serum-free medium by inhibiting transcription and destabilizing mRNA
-
oral gavage with glucose or injection with insulin decreases Rdh1 mRNA 50% or greater in mouse liver
-
removing serum from the medium of the human hepatoma cell line HepG2 increases isoforms Rdh10 and Rdh16 mRNA expression 2-3-fold by 4 h, by increasing transcription and stabilizing mRNA; removing serum from the medium of the human hepatoma cell line HepG2 increases isoforms Rdh10 and Rdh16 mRNA expression 2-3-fold by 4 h, by increasing transcription and stabilizing mRNA
-