1.1.1.105: all-trans-retinol dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about all-trans-retinol dehydrogenase (NAD+), go to the full flat file.

Reaction

all-trans-retinol-[cellular-retinol-binding-protein]
+
NAD+
=
all-trans-retinal-[cellular-retinol-binding-protein]
+
NADH
+
H+

Synonyms

all-trans retinol dehydrogenase, all-trans-retinol dehydrogenase, dehydrogenase, retinol, DHRS9, epidermal retinol dehydrogenase 2, LOC100185899, MDR, microsomal retinol dehydrogenase, mRDH1, NAD+-dependent retinoid-active short-chain dehydrogenase/reductase, P32, RDH-E2, RDH-like SDR, Rdh1, RDH10, RDH10a, RDH10b, RDH10c, RDH12, RDH16, RDH2, RDH7, RDH8, RDHE2, RDHE2S, RDHL, retinal reductase, retinene reductase, retinoid dehydrogenase/reductase, retinol dehydrogenase (vitamin A1), retinol dehydrogenase 10, retinol dehydrogenase 12, retinol dehydrogenase 2, retinol dehydrogenase 4, retinol dehydrogenase epidermal 2-similar, RL-HSD, RoDH-4, RoDH-like 3alpha-hydroxysteroid dehydrogenase, RoDH4, SDR16C5, SDR16C6, XP_2120364

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.105 all-trans-retinol dehydrogenase (NAD+)

Cloned

Cloned on EC 1.1.1.105 - all-trans-retinol dehydrogenase (NAD+)

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
both isoforms 1 and 2, expression in COS-7 cell with N-terminal His-tag
-
cloning of Rdh7
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expressed in COS-1 cells
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expressed in HEK-293T cells
expressed in Sf9 insect cells and in HEK-293 cells; RDH-E2 is expressed in Sf9 insect cells as a fusion to the C-terminal His6-tag
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expression in CHO-K1 cells
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expression in Escherichia coli
expression in HEK293 cells as FLAG-tagged fusions; expression in HEK293 cells as FLAG-tagged fusions
expression in HEK293 cells as FLAG-tagged fusions; expression in HEK293 cells as FLAG-tagged fusions; expression in HEK293 cells as FLAG-tagged fusions
expression in Sf9 cells, HepG2 and HEK293 cells
-
expression of His6-tagged RDH10 in Spodoptera frugiperda Sf9 insect cell membranes
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human RDHE2 exhibits a relatively low but reproducible activity when expressed in either HepG2 or HEK293 cells; human RDHE2S is unstable when expressed in HEK293 cells. RDHE2S protein produced in Sf9 cells is stable but has no detectable catalytic activity towards retinol
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RDH8 gene is located on 19p13, DNA and amino acid sequence determination and analysis, RDH8 genotping and phenotyping in Han Chinese population
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recombinant RoDH-4, expressed in microsomes of Sf9 insect cells
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retinol dehydrogenase 4
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