1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase

This is an abbreviated version, for detailed information about 3-oxoacyl-[acyl-carrier-protein] reductase, go to the full flat file.

Reaction

a (3R)-3-hydroxyacyl-[acyl-carrier protein]
+
NADP+
=
a 3-oxoacyl-[acyl-carrier protein]
+
NADPH
+
H+

Synonyms

3-ketoacyl acyl carrier protein reductase, 3-ketoacyl-(acyl-carrier-protein) reductase, 3-ketoacyl-ACP reductase, 3-ketoacyl-ACP(CoA) reductase, 3-ketoacyl-acyl carrier protein reductase, 3-ketoacyl-[acyl-carrier-protein] reductase, 3-oxoacyl-(acyl carrier protein) reductase, 3-oxoacyl-ACP reductase, 3-oxoacyl-AcpM reductase, 3-oxoacyl-thioester reductase, 3-oxoacyl-[ACP]reductase, ACP reductase, beta-ketoacyl acyl carrier protein (ACP) reductase, beta-ketoacyl acyl carrier protein reductase, beta-ketoacyl reductase, beta-ketoacyl thioester reductase, beta-ketoacyl-ACP reductase, beta-ketoacyl-acyl carrier protein reductase, beta-ketoacyl-[acyl carrier protein] reductase, beta-ketoacyl-[acyl-carrier protein] (ACP) reductase, BKR, FabG, FabG1, fabG4, KACPR, KCR1, KCR2, MabA, NADPH-specific 3-oxoacyl-[acylcarrier protein]reductase, OAR, Oar1p, PHA-specific acetoacetyl-CoA reductase, PhaB, polyhydroxyalkanoate-specific acetoacetyl coenzyme A reductase, reductase, 3-oxoacyl-[acyl carrier protein], RhlG

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase

Reference

Reference on EC 1.1.1.100 - 3-oxoacyl-[acyl-carrier-protein] reductase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shimakata, T.; Stumpf, P.K.
Purification and characterizations of beta-ketoacyl-[acyl-carrier-protein] reductase, beta-hydroxyacyl-[acylcarrier-protein] dehydrase, and enoyl-[acyl-carrier-protein] reductase from Spinacia oleracea leaves
Arch. Biochem. Biophys.
218
77-91
1982
Escherichia coli, Spinacia oleracea
Manually annotated by BRENDA team
Shimakata, T.; Stumpf, P.K.
The procaryotic nature of the fatty acid synthetase of developing Carthamus tinctorius L. (Safflower) seeds
Arch. Biochem. Biophys.
217
144-154
1982
Carthamus tinctorius
Manually annotated by BRENDA team
Sheldon, P.S.; Safford, R.; Slabas, A.R.; Kekwick, R.G.O.
3-Oxoacyl-[acyl carrier protein] reductase: a component of plant fatty acid synthase
Biochem. Soc. Trans.
16
392-393
1988
Brassica napus, Persea americana
-
Manually annotated by BRENDA team
Volpe, J.J.; Vagelos, P.R.
Saturated fatty acid biosynthesis and its regulation
Annu. Rev. Biochem.
42
21-60
1973
Escherichia coli
Manually annotated by BRENDA team
Toomey, R.E.; Wakil, S.J.
Studies on the mechanism of fatty acid synthesis. XV. Preparation and general properties of beta-ketoacyl acyl carrier protein reductase from Escherichia coli
Biochim. Biophys. Acta
116
189-197
1966
Escherichia coli
Manually annotated by BRENDA team
Sheldon, P.S.; Kekwick, R.G.O.; Smith, C.G.; Sidebottom, C.; Slabas, A.R.
3-Oxoacyl-[ACP] reductase from oil seed rape (Brassica napus)
Biochim. Biophys. Acta
1130
151-159
1992
Brassica napus
-
Manually annotated by BRENDA team
Sheldon, P.S.; Kekwick, R.G.O.; Sidebottom, C.; Smith, C.G.; Slabas, A.R.
3-Oxoacyl-(acyl-carrier protein) reductase from avocado (Persea americana) fruit mesocarp
Biochem. J.
271
713-720
1990
Persea americana
Manually annotated by BRENDA team
Shimakata, T.; Stumpf, P.K.
The purification and function of acetyl coenzyme A:acyl carrier protein transacylase
J. Biol. Chem.
258
3592-3598
1983
Brassica juncea, Carthamus tinctorius, Cuphea lutea, Persea americana, Pisum sativum, Spinacia oleracea
Manually annotated by BRENDA team
Hendren, R.W.; Bloch, K.
Fatty acid synthetases from Euglena gracilis. Separation of component activities of the ACP-dependent fatty acid synthetase and partial purification of the beta-ketoacyl-ACP synthetase
J. Biol. Chem.
255
1504-1508
1980
Euglena gracilis
Manually annotated by BRENDA team
Shimakata, T.; Stumpf, P.K.
Fatty acid synthetase of Spinacia oleracea leaves
Plant Physiol.
69
1257-1262
1982
Spinacia oleracea
Manually annotated by BRENDA team
Caughey, I.; Kekwick, R.G.O.
The characteristics of some components of the fatty acid synthetase system in the plastids from the mesocarp of avocado (Persea americana) fruit
Eur. J. Biochem.
123
553-561
1982
Persea americana
Manually annotated by BRENDA team
Klein, B.; Pawlowski, K.; Höricke-Grandpierre, C.; Schell, J.; Töpfer, R.
Isolation and characterization of a cDNA from Cuphea lanceolata encoding a beta-ketoacyl-ACP reductase
Mol. Gen. Genet.
233
122-128
1992
Cuphea lanceolata
Manually annotated by BRENDA team
Morbidoni, H.R.; de Mendoza, D.; Cronan, J.E.
Bacillus subtilis acyl carrier protein is encoded in a cluster of lipid biosynthesis genes
J. Bacteriol.
178
4794-4800
1996
Bacillus subtilis
Manually annotated by BRENDA team
Rafferty, J.B.; Fisher, M.; Langridge, S.J.; Martindale, W.; Thomas, N.C.; Simon, J.W.; Bithell, S.; Slabas, A.R.; Rice, D.W.
Crystallization of the NADP-dependent beta-keto acyl carrier protein reductase from Escherichia coli
Acta Crystallogr. Sect. D
54
427-429
1998
Escherichia coli
Manually annotated by BRENDA team
Fisher, M.; Sedelnikowa, S.E.; Martindale, W.; Thomas, N.C.; Simon, J.W.; Slabas, A.R.; Rafferty, J.B.
Crystallization of the NADP-dependent beta-keto acyl-carrier protein reductase from Brassica napus
Acta Crystallogr. Sect. D
56
86-88
2000
Brassica napus
Manually annotated by BRENDA team
Fisher, M.; Kroon, J.T.M.; Martindale, W.; Stuitje, A.R.; Slabas, A.R.; Rafferty, J.B.
The x-ray structure of Brassica napus beta-keto acyl carrier protein reductase and its implications for substrate binding and catalysis
Structure
8
339-347
2000
Brassica napus, Escherichia coli
Manually annotated by BRENDA team
Pillai, S.; Rajagopal, C.; Kapoor, M.; Kumar, G.; Gupta, A.; Surolia, N.
Functional characterization of beta-ketoacyl-ACP reductase (FabG) from Plasmodium falciparum
Biochem. Biophys. Res. Commun.
303
387-392
2003
Plasmodium falciparum, Plasmodium falciparum (Q965D6)
Manually annotated by BRENDA team
Wang, H.; Cronan, J.E.
Only one of the two annotated Lactococcus lactis fabG genes encodes a functional beta-ketoacyl-acyl carrier protein reductase
Biochemistry
43
11782-11789
2004
Lactococcus lactis
Manually annotated by BRENDA team
Lai, C.Y.; Cronan, J.E.
Isolation and characterization of beta-ketoacyl-acyl carrier protein reductase (fabG) mutants of Escherichia coli and Salmonella enterica serovar typhimurium
J. Bacteriol.
186
1869-1878
2004
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Hoang, T.T.; Sullivan, S.A.; Cusick, J.K.; Schweizer, H.P.
beta-Ketoacyl acyl carrier protein reductase (FabG) activity of the fatty acid biosynthetic pathway is a determining factor of 3-oxo-homoserine lactone acyl chain lengths
Microbiology
148
3849-3856
2002
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Poletto, S.S.; da Fonseca, I.O.; de Carvalho, L.P.; Basso, L.A.; Santos, D.S.
Selection of an Escherichia coli host that expresses mutant forms of Mycobacterium tuberculosis 2-trans enoyl-ACP(CoA) reductase and 3-ketoacyl-ACP(CoA) reductase enzymes
Protein Expr. Purif.
34
118-125
2004
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Nomura, C.T.; Taguchi, K.; Gan, Z.; Kuwabara, K.; Tanaka, T.; Takase, K.; Doi, Y.
Expression of 3-ketoacyl-acyl carrier protein reductase (fabG) genes enhances production of polyhydroxyalkanoate copolymer from glucose in recombinant Escherichia coli JM109
Appl. Environ. Microbiol.
71
4297-4306
2005
Escherichia coli, Pseudomonas sp., Pseudomonas sp. (Q4AE87)
Manually annotated by BRENDA team
Wickramasinghe, S.R.; Inglis, K.A.; Urch, J.E.; Mueller, S.; van Aalten, D.M.; Fairlamb, A.H.
Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis
Biochem. J.
393
447-457
2006
Plasmodium falciparum, Plasmodium falciparum (Q86RB1)
Manually annotated by BRENDA team
Patel, M.P.; Liu, W.S.; West, J.; Tew, D.; Meek, T.D.; Thrall, S.H.
Kinetic and chemical mechanisms of the fabG-encoded Streptococcus pneumoniae beta-ketoacyl-ACP reductase
Biochemistry
44
16753-16765
2005
Streptococcus pneumoniae
Manually annotated by BRENDA team
Silva, R.G.; de Carvalho, L.P.; Blanchard, J.S.; Santos, D.S.; Basso, L.A.
Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein (ACP) reductase: kinetic and chemical mechanisms
Biochemistry
45
13064-13073
2006
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Karmodiya, K.; Surolia, N.
Analyses of co-operative transitions in Plasmodium falciparum beta-ketoacyl acyl carrier protein reductase upon co-factor and acyl carrier protein binding
FEBS J.
273
4093-4103
2006
Plasmodium falciparum
Manually annotated by BRENDA team
Li, B.H.; Ma, X.F.; Wu, X.D.; Tian, W.X.
Inhibitory activity of chlorogenic acid on enzymes involved in the fatty acid synthesis in animals and bacteria
IUBMB Life
58
39-46
2006
Escherichia coli
Manually annotated by BRENDA team
Miller, D.J.; Zhang, Y.M.; Rock, C.O.; White, S.W.
Structure of RhlG, an essential beta-ketoacyl reductase in the rhamnolipid biosynthetic pathway of Pseudomonas aeruginosa
J. Biol. Chem.
281
18025-18032
2006
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Karmodiya, K.; Srivastav, R.K.; Surolia, N.
Production and purification of refolded recombinant Plasmodium falciparum beta-ketoacyl-ACP reductase from inclusion bodies
Protein Expr. Purif.
42
131-136
2005
Plasmodium falciparum
Manually annotated by BRENDA team
Mao, Q.; Duax, W.L.; Umland, T.C.
Crystallization and X-ray diffraction analysis of the beta-ketoacyl-acyl carrier protein reductase FabG from Aquifex aeolicus VF5
Acta Crystallogr. Sect. F
63
106-109
2007
Aquifex aeolicus VF5
Manually annotated by BRENDA team
Silva, R.G.; Rosado, L.A.; Santos, D.S.; Basso, L.A.
Mycobacterium tuberculosis beta-ketoacyl-ACP reductase: alpha-secondary kinetic isotope effects and kinetic and equilibrium mechanisms of substrate binding
Arch. Biochem. Biophys.
471
1-10
2008
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Zhang, F.; Luo, S.Y.; Ye, Y.B.; Zhao, W.H.; Sun, X.G.; Wang, Z.Q.; Li, R.; Sun, Y.H.; Tian, W.X.; Zhang, Y.X.
The antibacterial efficacy of aceraceous plant may be related to inhibition of bacterial beta-ketoacyl-ACP reductase (FabG)
Biotechnol. Appl. Biochem.
51
73-78
2008
Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis
Manually annotated by BRENDA team
Nomura, C.T.; Tanaka, T.; Eguen, T.E.; Appah, A.S.; Matsumoto, K.; Taguchi, S.; Ortiz, C.L.; Doi, Y.
FabG mediates polyhydroxyalkanoate production from both related and nonrelated carbon sources in recombinant Escherichia coli LS5218
Biotechnol. Prog.
24
342-351
2008
Escherichia coli
Manually annotated by BRENDA team
Karmodiya, K.; Sajad, S.; Sinha, S.; Maity, K.; Suguna, K.; Surolia, N.
Conformational stability and thermodynamic characterization of homotetrameric Plasmodium falciparum beta-ketoacyl-ACP reductase
IUBMB Life
59
441-449
2007
Plasmodium falciparum
Manually annotated by BRENDA team
Karioti, A.; Skaltsa, H.; Zhang, X.; Tonge, P.J.; Perozzo, R.; Kaiser, M.; Franzblau, S.G.; Tasdemir, D.
Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata
Phytomedicine
15
1125-1129
2008
Plasmodium falciparum K1
Manually annotated by BRENDA team
OHara, P.; Slabas, A.R.; Fawcett, T.
Antisense expression of 3-oxoacyl-ACP reductase affects whole plant productivity and causes collateral changes in activity of fatty acid synthase components
Plant Cell Physiol.
48
736-744
2007
Brassica napus, Brassica napus (Q949M3)
Manually annotated by BRENDA team
Zaccai, N.R.; Carter, L.G.; Berrow, N.S.; Sainsbury, S.; Nettleship, J.E.; Walter, T.S.; Harlos, K.; Owens, R.J.; Wilson, K.S.; Stuart, D.I.; Esnouf, R.M.
Crystal structure of a 3-oxoacyl-(acyl carrier protein) reductase (BA3989) from Bacillus anthracis at 2.4-.ANG. resolution
Proteins Struct. Funct. Bioinform.
70
562-567
2007
Bacillus anthracis (Q81JG6)
-
Manually annotated by BRENDA team
Vo, M.T.; Lee, K.W.; Jung, Y.M.; Lee, Y.H.
Comparative effect of overexpressed phaJ and fabG genes supplementing (R)-3-hydroxyalkanoate monomer units on biosynthesis of mcl-polyhydroxyalkanoate in Pseudomonas putida KCTC1639
J. Biosci. Bioeng.
106
95-98
2008
Pseudomonas putida (A5HIF6), Pseudomonas putida
Manually annotated by BRENDA team
Beaudoin, F.; Wu, X.; Li, F.; Haslam, R.P.; Markham, J.E.; Zheng, H.; Napier, J.A.; Kunst, L.
Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase
Plant Physiol.
150
1174-1191
2009
Arabidopsis thaliana
Manually annotated by BRENDA team
Hoelsch, K.; Havel, J.; Haslbeck, M.; Weuster-Botz, D.
Identification, cloning, and characterization of a novel ketoreductase from the cyanobacterium Synechococcus sp. strain PCC 7942
Appl. Environ. Microbiol.
74
6697-6702
2008
Synechococcus elongatus PCC 7942 (Q31QF3)
Manually annotated by BRENDA team
Han, J.; Lu, Q.; Zhou, L.; Liu, H.; Xiang, H.
Identification of the polyhydroxyalkanoate (PHA)-specific acetoacetyl coenzyme A reductase among multiple FabG paralogs in Haloarcula hispanica and reconstruction of the PHA biosynthetic pathway in Haloferax volcanii
Appl. Environ. Microbiol.
75
6168-6175
2009
Haloarcula hispanica, Haloarcula hispanica AS2049, Haloferax volcanii
Manually annotated by BRENDA team
Kristan, K.; Bratkovic, T.; Sova, M.; Gobec, S.; Prezelj, A.; Urleb, U.
Novel inhibitors of beta-ketoacyl-ACP reductase from Escherichia coli
Chem. Biol. Interact.
178
310-316
2009
Escherichia coli, Escherichia coli (P0AEK2)
Manually annotated by BRENDA team
Karmodiya, K.; Modak, R.; Sahoo, N.; Sajad, S.; Surolia, N.
Deciphering the key residues in Plasmodium falciparum beta-ketoacyl acyl carrier protein reductase responsible for interactions with Plasmodium falciparum acyl carrier protein
FEBS J.
275
4756-4766
2008
Plasmodium falciparum
Manually annotated by BRENDA team
Sun, Y.H.; Cheng, Q.; Tian, W.X.; Wu, X.D.
A substitutive substrate for measurements of beta-ketoacyl reductases in two fatty acid synthase systems
J. Biochem. Biophys. Methods
70
850-856
2008
Escherichia coli
Manually annotated by BRENDA team
Gurvitz, A.
Caenorhabditis elegans F09E10.3 encodes a putative 3-oxoacyl-thioester reductase of mitochondrial type 2 fatty acid synthase FASII that is functional in yeast
J. Biomed. Biotechnol.
FEHLT
0000
2009
Caenorhabditis elegans, Saccharomyces cerevisiae
Manually annotated by BRENDA team
Huang, H.; Wu, D.; Tian, W.X.; Ma, X.F.; Wu, X.D.
Antimicrobial effect by extracts of rhizome of Alpinia officinarum Hance may relate to its inhibition of beta-ketoacyl-ACP reductase
J. Enzyme Inhib. Med. Chem.
23
362-368
2008
Pseudomonas aeruginosa, Pseudomonas aeruginosa ATCC27853, Staphylococcus aureus, Staphylococcus aureus ATCC25923, Streptococcus pneumoniae, Streptococcus sp., synthetic construct
Manually annotated by BRENDA team
Gurvitz, A.
The essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2
Mol. Genet. Genomics
282
407-416
2009
Mycobacterium tuberculosis, Mycobacterium tuberculosis (O53665), Mycobacterium tuberculosis (P9WGT3), Mycobacterium tuberculosis H37Rv (P9WGT3), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Wu, D.; Wu, X.D.; You, X.F.; Ma, X.F.; Tian, W.X.
Inhibitory effects on bacterial growth and b-ketoacyl-ACP reductase by different species of maple leaf extracts and tannic acid
Phytother. Res.
24
535-541
2009
Acinetobacter calcoaceticus, Acinetobacter calcoaceticus 25001, Enterobacter aerogenes, Enterobacter aerogenes 45102, Enterobacter cloacae, Enterobacter cloacae 45301, Enterococcus sp., Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Pseudomonas aeruginosa, Salmonella enterica subsp. enterica serovar Typhi, Salmonella enterica subsp. enterica serovar Typhi H901, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens, Serratia marcescens 41002, Shigella dysenteriae, Shigella flexneri, Shigella sonnei, Shigella sonnei 51592, Staphylococcus aureus, Staphylococcus epidermidis
-
Manually annotated by BRENDA team
Karmodiya, K.; Surolia, N.
A unique and differential effect of denaturants on cofactor mediated activation of Plasmodium falciparum beta-ketoacyl-ACP reductase
Proteins Struct. Funct. Genet.
70
528-538
2008
Plasmodium falciparum
Manually annotated by BRENDA team
Zaccai, N.; Carter, L.; Berrow, N.; Sainsbury, S.; Nettleship, J.; Walter, T.; Harlos, K.; Owens, R.; Wilson, K.; Stuart, D.; Esnouf, R.
Crystal structure of a 3-oxoacyl-(acyl carrier protein) reductase (BA3989) from Bacillus anthracis at 2.4 A resolution
Proteins Struct. Funct. Genet.
70
562-567
2008
Bacillus anthracis (Q81JG6)
Manually annotated by BRENDA team
Subramanian, S.; Abendroth, J.; Phan, I.Q.; Olsen, C.; Staker, B.L.; Napuli, A.; Van Voorhis, W.C.; Stacy, R.; Myler, P.J.
Structure of 3-ketoacyl-(acyl-carrier-protein) reductase from Rickettsia prowazekii at 2.25 A resolution
Acta Crystallogr. Sect. F
67
1118-1122
2011
Rickettsia prowazekii (P50941), Rickettsia prowazekii
Manually annotated by BRENDA team
Rosado, L.A.; Caceres, R.A.; de Azevedo, W.F.; Basso, L.A.; Santos, D.S.
Role of Serine140 in the mode of action of Mycobacterium tuberculosis beta-ketoacyl-ACP Reductase (MabA)
BMC Res. Notes
5
526
2012
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Zhao, W.; Wang, Y.; Hao, W.; Zhao, M.; Peng, S.
In vitro inhibition of fatty acid synthase by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose plays a vital role in anti-tumour activity
Biochem. Biophys. Res. Commun.
445
346-351
2014
Homo sapiens
Manually annotated by BRENDA team
Liang, Y.; Tian, W.; Ma, X.
Inhibitory effects of grape skin extract and resveratrol on fatty acid synthase
BMC Complement. Altern. Med.
13
361
2013
Gallus gallus
Manually annotated by BRENDA team