1.1.1.1: alcohol dehydrogenase

This is an abbreviated version, for detailed information about alcohol dehydrogenase, go to the full flat file.

Reaction

a primary alcohol
+
NAD+
=
an aldehyde
+
NADH
+
H+

Synonyms

(R)-specific alcohol dehydrogenase, 40 kDa allergen, Aadh1, ADH, ADH 1, ADH class III, ADH I, ADH II, ADH-10, ADH-A, ADH-A2, ADH-B2, ADH-C2, ADH-HT, ADH-I, ADH1, ADH1B, ADH1C, ADH1C*1, ADH1C*2, Adh1p, ADH2, ADH3, ADH4, ADH5, ADH6Hp, ADH8, AdhA, AdhB, AdhC, AdhD, AdhE, ADS1, AFPDH, alcohol dehydrogenase, alcohol dehydrogenase (NAD), alcohol dehydrogenase 1, alcohol dehydrogenase 10, alcohol dehydrogenase 2, alcohol dehydrogenase 3, alcohol dehydrogenase 5, alcohol dehydrogenase I, alcohol dehydrogenase II, Alcohol dehydrogenase-B2, alcohol dependent dehydrogenase, alcohol-aldehyde/ketone oxidoreductase, NAD+-dependent, alcohol:NAD+ oxidoreductase, aldehyde dehydrogenase, aldehyde reductase, aldehyde/alcohol dehydrogenase, ALDH, aliphatic alcohol dehydrogenase, APE2239, APE_2239.1, ARAD1B16786p, bifunctional alcohol/aldehyde dehydrogenase, CHY1186, class I ADH, class I ALDH, class II ADH, class III ADH, class III alcohol dehydrogenase, class IV ADH, Cm-ADH2, Cthe_0423, DADH, dehydrogenase, alcohol, ethanol dehydrogenase, FALDH, FDH, Gastric alcohol dehydrogenase, Glutathione-dependent formaldehyde dehydrogenase, GSH-FDH, HLAD, HpADH3, HtADH, HvADH1, HVO_2428, iron-containing alcohol dehydrogenase, KlADH4, KlDH3, KmADH3, KmADH4, long-chain alkyl alcohol dehydrogenase, LSADH, medium chain alcohol dehydrogenase, medium-chain NAD+-dependent ADH, medium-chain secondary alcohol dehydrogenase, NAD(H)-dependent alcohol dehydrogenase, NAD+-ADH, NAD+-dependent (S)-stereospecific alcohol dehydrogenase, NAD+-dependent alcohol dehydrogenase, NAD-dependent alcohol dehydrogenase, NAD-dependent medium-chain ADH, NAD-specific aromatic alcohol dehydrogenase, NADH-alcohol dehydrogenase, NADH-aldehyde dehydrogenase, NADH-dependent alcohol dehydrogenase, Octanol dehydrogenase, PF0991 protein, PF1960, primary alcohol dehydrogenase, Retinol dehydrogenase, SaADH, SaADH2, Saci_1232, SADH, SCAD, sec-ADH A, short-chain ADH, short-chain NAD(H)-dependent dehydrogenase/reductase, SSADH, SsADH-10, SSO2536, ST0053, Ta1316 ADH, TaDH, TBADH, Teth39_0206, Teth39_0218, Teth514_0627, TK0845, Tsac_0416, Y-ADH, YADH, YADH-1, yeast alcohol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.1 alcohol dehydrogenase

pH Range

pH Range on EC 1.1.1.1 - alcohol dehydrogenase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4 - 8.5
-
oxidation reaction activity range, profile overview
4 - 7.5
pH 4.0: about 80% of maximal activity, pH 7.5: about 60% of maximal activity
4 - 8
-
pH 4.0: about 35% of maximal activity, pH 8.0: about 70% of maximal activity
4.9 - 5.8
pH 4.9: about 25% of maximal activity, pH 5.8: about 40% of maximal activity, reduction reaction
5 - 8
-
pH 5.0: about 50% of maximal activity, pH 8.0: about 40% of maximal activity, reduction of phenylacetaldehyde
5.2 - 6.8
Sporotrichum pulverulentum
-
pH 5.2: about 35% of maximal activity, pH 6.8: about 55% of maximal activity, oxidation of ethanol
5.5 - 9
-
reduction reaction activity range, profile overview
5.5
-
complete inactivation
5.5 - 7.5
pH 5.5: about 35% of maximal activity, pH 7.5: about 55% of maximal activity, reduction of benzaldehyde
6 - 10
-
-
6
50% of maximum activity for reduction of aldehydes
6.7 - 8.5
pH 6.7: about 40% of maximal activity, pH 8.5: about 85% of maximal activity, oxidation reaction
7 - 9.6
-
pH 7.0: about 70% of maximal activity, pH 9.6: about 50% of maximal activity, reduction of 2-pentanone
7 - 8
pH 7: 41% of maximal activity, pH 8: 59% of maximal activity
7.2 - 9.2
Sporotrichum pulverulentum
-
pH 7.2: about 50% of maximal activity, pH 9.2: about 60% of maximal activity
7.5 - 10.8
pH 7.5: about 35% of maximal activity, pH 10.8: about 50% of maximal activity, oxidation of 1-hexanol
8 - 12
-
pH 8.0: about 50% of maximal activity, pH 12.0: about 50% of maximal activity, oxidation of 2-phenylethanol
8 - 10.5
-
pH 8.0: about 40% of maximal activity, pH 10.5: about 85% of maximal activity
8 - 12
8.2 - 9.5
-
pH 8.2: about 10% of maximal activity, pH 9.5: about 40% of maximal activity
8.5
-
more than 50% of maximum activity
9 - 12
-
pH 9.0: about 25% of maximal activity, pH 12.0: about 80% of maximal activity, pyrazole-sensitive enzyme
9.5 - 11.5
-
pH 9.5: about 40% of maximal activity, pH 11.5: about 85% of maximal activity, ethanol oxidation enzyme form ADH-3
9.6 - 11.5
-
pH 9.5: about 40% of maximal activity, pH 11.5: about 30% of maximal activity, oxidation of 2-pentanol
10 - 11
-
pH 10.0: about 50% of maximal activity, pH 11.0: about 75% of maximal activity, pyrazole-insensitive enzyme