1.1.1.1: alcohol dehydrogenase

This is an abbreviated version, for detailed information about alcohol dehydrogenase, go to the full flat file.

Reaction

a primary alcohol
+
NAD+
=
an aldehyde
+
NADH
+
H+

Synonyms

(R)-specific alcohol dehydrogenase, 40 kDa allergen, Aadh1, ADH, ADH 1, ADH class III, ADH I, ADH II, ADH-10, ADH-A, ADH-A2, ADH-B2, ADH-C2, ADH-HT, ADH-I, ADH1, ADH1B, ADH1C, ADH1C*1, ADH1C*2, Adh1p, ADH2, ADH3, ADH4, ADH5, ADH6Hp, ADH8, AdhA, AdhB, AdhC, AdhD, AdhE, ADS1, AFPDH, alcohol dehydrogenase, alcohol dehydrogenase (NAD), alcohol dehydrogenase 1, alcohol dehydrogenase 10, alcohol dehydrogenase 2, alcohol dehydrogenase 3, alcohol dehydrogenase 5, alcohol dehydrogenase I, alcohol dehydrogenase II, Alcohol dehydrogenase-B2, alcohol dependent dehydrogenase, alcohol-aldehyde/ketone oxidoreductase, NAD+-dependent, alcohol:NAD+ oxidoreductase, aldehyde dehydrogenase, aldehyde reductase, aldehyde/alcohol dehydrogenase, ALDH, aliphatic alcohol dehydrogenase, APE2239, APE_2239.1, ARAD1B16786p, bifunctional alcohol/aldehyde dehydrogenase, CHY1186, class I ADH, class I ALDH, class II ADH, class III ADH, class III alcohol dehydrogenase, class IV ADH, Cm-ADH2, Cthe_0423, DADH, dehydrogenase, alcohol, ethanol dehydrogenase, FALDH, FDH, Gastric alcohol dehydrogenase, Glutathione-dependent formaldehyde dehydrogenase, GSH-FDH, HLAD, HpADH3, HtADH, HvADH1, HVO_2428, iron-containing alcohol dehydrogenase, KlADH4, KlDH3, KmADH3, KmADH4, long-chain alkyl alcohol dehydrogenase, LSADH, medium chain alcohol dehydrogenase, medium-chain NAD+-dependent ADH, medium-chain secondary alcohol dehydrogenase, NAD(H)-dependent alcohol dehydrogenase, NAD+-ADH, NAD+-dependent (S)-stereospecific alcohol dehydrogenase, NAD+-dependent alcohol dehydrogenase, NAD-dependent alcohol dehydrogenase, NAD-dependent medium-chain ADH, NAD-specific aromatic alcohol dehydrogenase, NADH-alcohol dehydrogenase, NADH-aldehyde dehydrogenase, NADH-dependent alcohol dehydrogenase, Octanol dehydrogenase, PF0991 protein, PF1960, primary alcohol dehydrogenase, Retinol dehydrogenase, SaADH, SaADH2, Saci_1232, SADH, SCAD, sec-ADH A, short-chain ADH, short-chain NAD(H)-dependent dehydrogenase/reductase, SSADH, SsADH-10, SSO2536, ST0053, Ta1316 ADH, TaDH, TBADH, Teth39_0206, Teth39_0218, Teth514_0627, TK0845, Tsac_0416, Y-ADH, YADH, YADH-1, yeast alcohol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.1 alcohol dehydrogenase

pH Optimum

pH Optimum on EC 1.1.1.1 - alcohol dehydrogenase

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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3
reduction of aldehydes
5.1
reduction of ketones; reduction reaction
5.5
-
assay at, reverse reaction, ADH I
5.5 - 6
-
reduction reaction
5.6 - 6.5
Sporotrichum pulverulentum
-
oxidation of ethanol
6 - 7
-
reduction of N-benzyl-3-pyrrolidinone
6.1
-
reduction of ketones
6.7 - 7.3
-
reaction with acetaldehyde + NADH
6.7 - 7
oxidation of ethanol
6.9 - 7.5
-
apparent optimal pH for the benzaldehyde reduction
7 - 7.5
7.4
-
acetaldehyde reduction of isoenzyme beta2,beta2
7.6
-
assay at, class II enzyme, reduction reaction
7.7 - 8.6
-
reaction with ethanol + NAD+
8 - 8.4
Sporotrichum pulverulentum
-
reduction of aldehyde
8.1
-
reduction of propan-2-ol or ethanol
8.3
-
alcohol dehydrogenase IV
8.5 - 8.8
-
ethanol oxidation, isoenzyme beta2,beta2, beta2,beta1, alpha,beta2 and beta2gamma1
8.6 - 8.8
-
reduction of acetaldehyde, isoenzyme I
8.7
-
-
8.9
-
oxidation of ethanol
9
-
recombinant enzyme
9 - 10
9 - 10
-
substrate: (S)-(-)-1-phenylethanol and 3 mM NAD+ or methyl benzoylformate + NADH
9
-
oxidation of ethanol
9.1
-
reduction of NAD+
9.9
-
and second optimum at pH 7.5
10
optimally active with 1-butanol at pH 10.0 with 4 M KCl
10 - 10.5
-
and a second optimum at pH 10.0-10.5, ADH Indianapolis form 2 and 3
10.7
-
oxidation of ethanol, isoenzyme 2, 3 and 4
11.2
-
oxidation of ethanol, pyrazole-sensitive enzyme form
additional information