1.1.1.1: alcohol dehydrogenase

This is an abbreviated version, for detailed information about alcohol dehydrogenase, go to the full flat file.

Reaction

a primary alcohol
+
NAD+
=
an aldehyde
+
NADH
+
H+

Synonyms

(R)-specific alcohol dehydrogenase, 40 kDa allergen, Aadh1, ADH, ADH 1, ADH class III, ADH I, ADH II, ADH-10, ADH-A, ADH-A2, ADH-B2, ADH-C2, ADH-HT, ADH-I, ADH1, ADH1B, ADH1C, ADH1C*1, ADH1C*2, Adh1p, ADH2, ADH3, ADH4, ADH5, ADH6Hp, ADH8, AdhA, AdhB, AdhC, AdhD, AdhE, ADS1, AFPDH, alcohol dehydrogenase, alcohol dehydrogenase (NAD), alcohol dehydrogenase 1, alcohol dehydrogenase 10, alcohol dehydrogenase 2, alcohol dehydrogenase 3, alcohol dehydrogenase 5, alcohol dehydrogenase I, alcohol dehydrogenase II, Alcohol dehydrogenase-B2, alcohol dependent dehydrogenase, alcohol-aldehyde/ketone oxidoreductase, NAD+-dependent, alcohol:NAD+ oxidoreductase, aldehyde dehydrogenase, aldehyde reductase, aldehyde/alcohol dehydrogenase, ALDH, aliphatic alcohol dehydrogenase, APE2239, APE_2239.1, ARAD1B16786p, bifunctional alcohol/aldehyde dehydrogenase, CHY1186, class I ADH, class I ALDH, class II ADH, class III ADH, class III alcohol dehydrogenase, class IV ADH, Cm-ADH2, Cthe_0423, DADH, dehydrogenase, alcohol, ethanol dehydrogenase, FALDH, FDH, Gastric alcohol dehydrogenase, Glutathione-dependent formaldehyde dehydrogenase, GSH-FDH, HLAD, HpADH3, HtADH, HvADH1, HVO_2428, iron-containing alcohol dehydrogenase, KlADH4, KlDH3, KmADH3, KmADH4, long-chain alkyl alcohol dehydrogenase, LSADH, medium chain alcohol dehydrogenase, medium-chain NAD+-dependent ADH, medium-chain secondary alcohol dehydrogenase, NAD(H)-dependent alcohol dehydrogenase, NAD+-ADH, NAD+-dependent (S)-stereospecific alcohol dehydrogenase, NAD+-dependent alcohol dehydrogenase, NAD-dependent alcohol dehydrogenase, NAD-dependent medium-chain ADH, NAD-specific aromatic alcohol dehydrogenase, NADH-alcohol dehydrogenase, NADH-aldehyde dehydrogenase, NADH-dependent alcohol dehydrogenase, Octanol dehydrogenase, PF0991 protein, PF1960, primary alcohol dehydrogenase, Retinol dehydrogenase, SaADH, SaADH2, Saci_1232, SADH, SCAD, sec-ADH A, short-chain ADH, short-chain NAD(H)-dependent dehydrogenase/reductase, SSADH, SsADH-10, SSO2536, ST0053, Ta1316 ADH, TaDH, TBADH, Teth39_0206, Teth39_0218, Teth514_0627, TK0845, Tsac_0416, Y-ADH, YADH, YADH-1, yeast alcohol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.1 alcohol dehydrogenase

Turnover Number

Turnover Number on EC 1.1.1.1 - alcohol dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
101
(2E)-but-2-en-1-ol
Yokenella sp.
W6CX26
pH 8.0, 55°C
-
405
(2E)-but-2-enal
Yokenella sp.
W6CX26
pH 6.5, 65°C
7.1
(R)-1-indanol
Sulfolobus acidocaldarius
Q4J702
65°C, pH 8.0; pH 8.0, 65°C
1 - 2
(R)-2-butanol
0.053
(R)-2-octanol
Equus caballus
-
-
1.01 - 1.9
(R)-2-pentanol
13.5
(R)-alpha-tetralol
Sulfolobus acidocaldarius
Q4J702
65°C, pH 8.0; pH 8.0, 65°C
61.4
(S)-(+)-1-indanol
Thermus thermophilus
-
65°C
57
(S)-(+)-alpha-tetraol
Thermus thermophilus
-
65°C
1.1
(S)-(-)-1-phenylethanol
Thermus thermophilus
-
65°C
13.7 - 61.4
(S)-1-indanol
1.1
(S)-1-phenylethanol
Thermus thermophilus
-
pH 10.5, 65°C
1 - 4.8
(S)-2-butanol
1.52
(S)-2-octanol
Equus caballus
-
-
0.87 - 6.7
(S)-2-pentanol
2.1 - 57
(S)-alpha-tetralol
0.41 - 48.8
1-butanol
0.51 - 11.9
1-Heptanol
0.37 - 13.3
1-Hexanol
6.2 - 45.7
1-Indanol
8.3
1-Indanone
Thermus thermophilus
-
65°C; pH 10.5, 65°C
1 - 260.7
1-Octanol
0.183 - 48.8
1-Pentanol
17.1
1-phenyl-1,2-propandione
Thermus thermophilus
-
pH 10.5, 65°C
3.1 - 17.1
1-phenyl-1,2-propanedione
35.7
1-phenylethanol
Thermococcus kodakarensis
Q5JI09
pH 9.0, 70°C
0.26 - 16.6
1-propanol
0.021
11-cis-retinal
Equus caballus
-
reduction with NADH
0.022
11-cis-retinol
Equus caballus
-
oxidation with NAD+
1.03 - 20
12-hydroxydodecanoate
0.333
12-Hydroxydodecanoic acid
Homo sapiens
-
-
27.6 - 34.3
12-hydroxylauric acid methyl ester
-
308
12-oxolauric acid methyl ester
Geobacillus stearothermophilus
-
wild-type, pH 8.0, 60°C
-
0.018
13-cis-retinal
Equus caballus
-
reduction with NADH
0.018
13-cis-retinol
Equus caballus
-
oxidation with NAD+
6.17
16-hydroxyhexadecanoate
Homo sapiens
-
-
3.2
2',3',4',5',6'-pentafluoroacetophenone
Sulfolobus acidocaldarius
-
65°C, pH 5.0
1.7 - 25.5
2,2,2-trifluoroacetophenone
0.65
2,2-dichloroacetophenone
Sulfolobus acidocaldarius
-
65°C, pH 5.0
43.8
2,3-Butanediol
Thermococcus kodakarensis
Q5JI09
pH 9.0, 70°C
0.48 - 4.75
2-butanol
0.12
2-butanone
Equus caballus
-
-
1.67 - 213
2-Buten-1-ol
0.4
2-decanone
Aeropyrum pernix
-
pH 8.0, 60°C
2.83
2-deoxy-D-ribose
Homo sapiens
-
-
1.6
2-ethoxyethanol
Sulfolobus solfataricus
-
wild type enzyme, in 0.1 M glycine-NaOH buffer (pH 10.5), at 65°C
0.73
2-Heptanone
Aeropyrum pernix
-
pH 8.0, 60°C
1.08
2-Hexanone
Aeropyrum pernix
-
pH 8.0, 60°C
0.7 - 1
2-nonanone
Aeropyrum pernix
-
pH 8.0, 60°C
0.74
2-Octanone
Aeropyrum pernix
-
pH 8.0, 60°C
0.6
2-Pentanol
Aeropyrum pernix
-
pH 8.0, 60°C
0.0713 - 0.77
2-Pentanone
0.24 - 287
2-propanol
0.22 - 1.22
3,4-dihydro-retinal
0.088 - 2.5
3,4-dihydro-retinol
1.2 - 2
3-bromobenzyl alcohol
1.2
3-bromobenzylalcohol
Sulfolobus solfataricus
-
in the presence of 3 mM NAD+, in 0.1 M glycine-NaOH, pH 9.2, at 65°C
3.1
3-Methoxybenzaldehyde
Thermus thermophilus
-
65°C
1.4 - 16
3-Methoxybenzyl alcohol
1.2 - 1.4
3-methoxybenzylalcohol
0.08 - 0.27
3-methyl-1-butanol
7.72
3-methyl-cyclohexanol
Sulfolobus solfataricus
-
-
1.22
3-methylbutan-2-one
Sulfolobus solfataricus
-
-
2.17 - 3.8
3-methylcyclohexanone
2.05
3-oxo-5beta-androstan-17beta-ol
Equus caballus
-
-
1.5 - 2.26
3-Pentanol
0.36
3-Pentanone
Equus caballus
-
-
7.5
3-Phenyl-1-propanol
Homo sapiens
-
-
0.683
3-Pyridylcarbinol
Homo sapiens
-
pH 7.5, anodic enzyme form
1.1 - 3.5
4-bromobenzyl alcohol
1.1
4-bromobenzylalcohol
Sulfolobus solfataricus
-
in the presence of 3 mM NAD+, in 0.1 M glycine-NaOH, pH 9.2, at 65°C
0.7
4-carboxybenzaldehyde
145 - 432
4-chloroacetophenone
0.092 - 34.2
4-hydroxy-retinol
0.6 - 20.5
4-methoxybenzaldehyde
0.37 - 25.5
4-methoxybenzyl alcohol
1.5
4-methoxybenzylalcohol
Sulfolobus solfataricus
-
in the presence of 3 mM NAD+, in 0.1 M glycine-NaOH, pH 9.2, at 65°C
0.071
4-methoxyphenylacetone
Aeropyrum pernix
-
pH 8.0, 60°C
6.7 - 18.6
4-Methyl-1-pentanol
4.6
4-Nitrobenzaldehyde
0.167 - 20
4-oxo-retinal
0.9
5beta-Pregnan-21-ol-3,20-dione hemisuccinate
Equus caballus
-
-
0.023
9-cis-retinal
Equus caballus
-
reduction with NADH
0.025
9-cis-retinol
Equus caballus
-
oxidation with NAD+
0.3 - 3500
acetaldehyde
13.7
acetoin
Thermococcus kodakarensis
Q5JI09
pH 6.0, 70°C
0.317 - 0.33
acetone
211 - 288
acetophenone
0.35 - 1.9
all-trans retinol
0.018 - 2.5
all-trans-retinal
0.028 - 1.55
all-trans-retinol
48.1
alpha-tetralol
Thermus thermophilus
-
65°C
7.7
alpha-tetralone
Thermus thermophilus
-
65°C; pH 10.5, 65°C
0.983
Anisaldehyde
Sulfolobus solfataricus
-
-
0.36 - 360
benzaldehyde
1.6
benzil
Sulfolobus acidocaldarius
-
65°C, pH 5.0
0.35 - 93.3
benzyl alcohol
1.4
benzylalcohol
Sulfolobus solfataricus
-
in the presence of 3 mM NAD+, in 0.1 M glycine-NaOH, pH 9.2, at 65°C
1.97 - 7.22
butan-1-ol
0.31 - 11.9
butan-2-ol
1.93
butan-2-one
Sulfolobus solfataricus
-
-
102
Butanal
Mycobacterium sp.
W8VSK8
cosubstrate NADH, pH 7.0, 30°C
0.0833 - 118
butanol
0.94
Butyl alcohol
Equus caballus
-
-
0.36 - 931
Butyraldehyde
317 - 576
Capronaldehyde
55
cinnamaldehyde
Geobacillus stearothermophilus
-
pH 7.7, 60°C
43 - 133
cinnamyl alcohol
0.98
cis-decahydro-1-naphthol
Sulfolobus acidocaldarius
Q4J702
65°C, pH 8.0
4.4 - 7
cycloheptanol
0.167 - 15.9
Cyclohexanol
1.27 - 5.9
cyclohexanone
1.02
Cyclopentanone
Sulfolobus solfataricus
-
-
0.00086 - 3000
ethanol
26
ethyl 3-methyl-2-oxobutyrate
Sulfolobus acidocaldarius
-
65°C, pH 5.0
1.9 - 50.1
ethyl benzoylformate
50.1
ethyl oxo(phenyl)acetate
Thermus thermophilus
-
pH 10.5, 65°C
-
3.97
ethyl pyruvate
Carboxydothermus hydrogenoformans
-
pH 6.5, 50°C, recombinant enzyme
0.75 - 4.5
ethylene glycol
56.6
hexaldehyde
Equus caballus
-
-
0.167 - 86.5
Hexanol
0.99
hexyl alcohol
Equus caballus
-
-
22
isatin
Sulfolobus acidocaldarius
Q4J702
65°C, pH 5.5; pH 5.5, 65°C
16.6
isoborneol
Sulfolobus acidocaldarius
-
65°C, pH 10.5
0.82 - 29
Isobutyraldehyde
0.58
Isopropanol
Equus caballus
-
-
0.05 - 3.1
methanol
6.2
methyl benzoylformate
Sulfolobus acidocaldarius
Q4J702
65°C, pH 5.5
9.2
methyl o-chlorobenzoylformate
Sulfolobus acidocaldarius
Q4J702
65°C, pH 5.5; pH 5.5, 65°C
38.1
methyl oxo(phenyl)acetate
Thermus thermophilus
-
pH 10.5, 65°C
38.1
methylbenzoylformate
Thermus thermophilus
-
65°C
2.63 - 8.58
methylcrotonyl alcohol
2.58 - 195
n-butanol
2.35 - 4.08
n-Hexanol
0.4 - 443.1
NAD+
0.38 - 1646
NADH
10.5 - 283.1
NADP+
433 - 4808
NADPH
1.85
octan-1-ol
Coturnix coturnix
-
enzyme form ADH-3
3.33 - 518.4
octanal
0.038 - 8.33
Octanol
0.24
p-nitrophenyl octanoate
Equus caballus
-
-
2.92
pentan-1-ol
Coturnix coturnix
-
enzyme form ADH-3
2.92
pentan-3-ol
Sulfolobus solfataricus
-
-
3.82
pentan2-ol
Sulfolobus solfataricus
-
-
0.245 - 56.2
Pentanol
202 - 303
phenylacetaldehyde
4.03
propan-1-ol
Sulfolobus solfataricus
-
-
5.8 - 53.1
propan-2-ol
17.2 - 28.7
Propanol
41.9
propionaldehyde
Equus caballus
-
-
1.17
Propyl alcohol
Equus caballus
-
-
0.087 - 0.11
retinol
0.072
tert-butyl acetoacetate
Aeropyrum pernix
-
pH 8.0, 60°C
9.6
tetralin-1-ol
Sulfolobus acidocaldarius
-
65°C, pH 10.5
0.21 - 18.9
trans-cinnamaldehyde
1.83
tryptophol
Homo sapiens
-
-
418 - 528
Valeraldehyde
0.467 - 8.67
Vanillyl alcohol
additional information
additional information
-