1.1.1.1: alcohol dehydrogenase

This is an abbreviated version, for detailed information about alcohol dehydrogenase, go to the full flat file.

Reaction

a primary alcohol
+
NAD+
=
an aldehyde
+
NADH
+
H+

Synonyms

(R)-specific alcohol dehydrogenase, 40 kDa allergen, Aadh1, ADH, ADH 1, ADH class III, ADH I, ADH II, ADH-10, ADH-A, ADH-A2, ADH-B2, ADH-C2, ADH-HT, ADH-I, ADH1, ADH1B, ADH1C, ADH1C*1, ADH1C*2, Adh1p, ADH2, ADH3, ADH4, ADH5, ADH6Hp, ADH8, AdhA, AdhB, AdhC, AdhD, AdhE, ADS1, AFPDH, alcohol dehydrogenase, alcohol dehydrogenase (NAD), alcohol dehydrogenase 1, alcohol dehydrogenase 10, alcohol dehydrogenase 2, alcohol dehydrogenase 3, alcohol dehydrogenase 5, alcohol dehydrogenase I, alcohol dehydrogenase II, Alcohol dehydrogenase-B2, alcohol dependent dehydrogenase, alcohol-aldehyde/ketone oxidoreductase, NAD+-dependent, alcohol:NAD+ oxidoreductase, aldehyde dehydrogenase, aldehyde reductase, aldehyde/alcohol dehydrogenase, ALDH, aliphatic alcohol dehydrogenase, APE2239, APE_2239.1, ARAD1B16786p, bifunctional alcohol/aldehyde dehydrogenase, CHY1186, class I ADH, class I ALDH, class II ADH, class III ADH, class III alcohol dehydrogenase, class IV ADH, Cm-ADH2, Cthe_0423, DADH, dehydrogenase, alcohol, ethanol dehydrogenase, FALDH, FDH, Gastric alcohol dehydrogenase, Glutathione-dependent formaldehyde dehydrogenase, GSH-FDH, HLAD, HpADH3, HtADH, HvADH1, HVO_2428, iron-containing alcohol dehydrogenase, KlADH4, KlDH3, KmADH3, KmADH4, long-chain alkyl alcohol dehydrogenase, LSADH, medium chain alcohol dehydrogenase, medium-chain NAD+-dependent ADH, medium-chain secondary alcohol dehydrogenase, NAD(H)-dependent alcohol dehydrogenase, NAD+-ADH, NAD+-dependent (S)-stereospecific alcohol dehydrogenase, NAD+-dependent alcohol dehydrogenase, NAD-dependent alcohol dehydrogenase, NAD-dependent medium-chain ADH, NAD-specific aromatic alcohol dehydrogenase, NADH-alcohol dehydrogenase, NADH-aldehyde dehydrogenase, NADH-dependent alcohol dehydrogenase, Octanol dehydrogenase, PF0991 protein, PF1960, primary alcohol dehydrogenase, Retinol dehydrogenase, SaADH, SaADH2, Saci_1232, SADH, SCAD, sec-ADH A, short-chain ADH, short-chain NAD(H)-dependent dehydrogenase/reductase, SSADH, SsADH-10, SSO2536, ST0053, Ta1316 ADH, TaDH, TBADH, Teth39_0206, Teth39_0218, Teth514_0627, TK0845, Tsac_0416, Y-ADH, YADH, YADH-1, yeast alcohol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.1 alcohol dehydrogenase

KCat KM Value

KCat KM Value on EC 1.1.1.1 - alcohol dehydrogenase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
11
(2E)-but-2-en-1-ol
Yokenella sp.
W6CX26
pH 8.0, 55C
210508
122
(2E)-but-2-enal
Yokenella sp.
W6CX26
pH 6.5, 65C
38719
2.98
(R)-1-indanol
Sulfolobus acidocaldarius
Q4J702
65C, pH 8.0; pH 8.0, 65C
13100
10.5
(R)-alpha-tetralol
Sulfolobus acidocaldarius
Q4J702
65C, pH 8.0; pH 8.0, 65C
42133
2.14 - 14.6
(S)-1-indanol
4637
0.06
(S)-1-phenylethanol
Thermus thermophilus
-
pH 10.5, 65C
4333
2 - 13.6
(S)-alpha-tetralol
14398
0.01
1,2-propanediol
Oenococcus oeni
-
pH 8.0, 60C, recombinant enzyme
862
0.01
1,3-Propanediol
Oenococcus oeni
-
pH 9.0, 60C, recombinant enzyme
2925
0.69
1-butanol
Aeropyrum pernix
-
pH 8.0, 60C
556
2.5
1-Hexanol
Aeropyrum pernix
-
pH 8.0, 60C
1214
0.71
1-Indanol
Sulfolobus acidocaldarius
-
65C, pH 10.5
3175
0.3
1-Indanone
Thermus thermophilus
-
pH 10.5, 65C
3431
67.2
1-Octanol
Geobacillus thermodenitrificans
A4IP64, A4ISB9
cosubstrate NADP+, pH 8.0, 60C
1228
1.1
1-Pentanol
Aeropyrum pernix
-
pH 8.0, 60C
1156
2.9
1-phenyl-1,2-propandione
Thermus thermophilus
-
pH 10.5, 65C
90130
0.25 - 1.06
1-phenyl-1,2-propanedione
3675
0.15
1-phenylethanol
Thermococcus kodakarensis
Q5JI09
pH 9.0, 70C
3432
0.25
1-propanol
Aeropyrum pernix
-
pH 8.0, 60C
660
320 - 340
12-hydroxylauric acid methyl ester
210505
4700
12-oxolauric acid methyl ester
Geobacillus stearothermophilus
-
wild-type, pH 8.0, 60C
210506
0.27
2',3',4',5',6'-pentafluoroacetophenone
Sulfolobus acidocaldarius
-
65C, pH 5.0
19167
0.27 - 2.3
2,2,2-trifluoroacetophenone
4175
5.91
2,2-dichloroacetophenone
Sulfolobus acidocaldarius
-
65C, pH 5.0
37992
0.71
2,3-Butanediol
Thermococcus kodakarensis
Q5JI09
pH 9.0, 70C
2004
0.46
2-butanol
Aeropyrum pernix
-
pH 8.0, 60C
1132
2.7
2-decanone
Aeropyrum pernix
-
pH 8.0, 60C
7438
0.62
2-Heptanone
Aeropyrum pernix
-
pH 8.0, 60C
3777
0.22
2-Hexanone
Aeropyrum pernix
-
pH 8.0, 60C
3966
3.3
2-nonanone
Aeropyrum pernix
-
pH 8.0, 60C
9505
2.6
2-Octanone
Aeropyrum pernix
-
pH 8.0, 60C
5474
0.79
2-Pentanol
Aeropyrum pernix
-
pH 8.0, 60C
2329
0.15
2-Pentanone
Aeropyrum pernix
-
pH 8.0, 60C
1911
0.097 - 5
2-propanol
682
0.06
3-methylcyclohexanone
Sulfolobus acidocaldarius
Q4J702
65C, pH 5.5
3972
389 - 1036
4-chloroacetophenone
6308
0.7
4-methoxybenzaldehyde
Thermus thermophilus
-
pH 6.0, 65C
1016
0.026 - 0.53
4-methoxybenzyl alcohol
1158
0.54
4-methoxyphenylacetone
Aeropyrum pernix
-
pH 8.0, 60C
194813
0.048 - 70000
acetaldehyde
90
0.45
acetoin
Thermococcus kodakarensis
Q5JI09
pH 6.0, 70C
1274
392 - 1055
acetophenone
982
1.3
alpha-tetralone
Thermus thermophilus
-
pH 10.5, 65C
7745
3.66 - 899
benzaldehyde
146
3.72
benzil
Sulfolobus acidocaldarius
-
65C, pH 5.0
1673
0.189 - 6.6
benzyl alcohol
260
0.3
butan-1-ol
Mycobacterium sp.
W8VSK8
cosubstrate NAD+, pH 7.0, 30C
2646
0.7
Butan-2,3-diol
Pyrococcus furiosus
-
pH 8.8, 70C
43887
210
Butanal
Mycobacterium sp.
W8VSK8
cosubstrate NADH, pH 7.0, 30C
540
8600
Butyraldehyde
Geobacillus stearothermophilus
-
wild-type, pH 8.0, 60C
499
1640 - 2618
Capronaldehyde
7164
1835
cinnamaldehyde
Geobacillus stearothermophilus
-
pH 7.7, 60C
1071
391
cinnamyl alcohol
Geobacillus stearothermophilus
-
pH 7.7, 60C
936
0.23
cis-decahydro-1-naphthol
Sulfolobus acidocaldarius
Q4J702
65C, pH 8.0
42132
0.47 - 1.37
cycloheptanol
9530
0.73
Cyclohexanol
Aeropyrum pernix
-
pH 8.0, 60C
873
0.91
cyclohexanone
Aeropyrum pernix
-
pH 8.0, 60C
1299
0.017 - 6667
ethanol
69
1.57
ethyl 3-methyl-2-oxobutyrate
Sulfolobus acidocaldarius
-
65C, pH 5.0
24214
0.44 - 0.45
ethyl benzoylformate
5419
50.1
ethyl oxo(phenyl)acetate
Thermus thermophilus
-
pH 10.5, 65C
210507
31
isatin
Sulfolobus acidocaldarius
Q4J702
65C, pH 5.5; pH 5.5, 65C
805
20.5
isoborneol
Sulfolobus acidocaldarius
-
65C, pH 10.5
42135
0.95
methyl benzoylformate
Sulfolobus acidocaldarius
Q4J702
65C, pH 5.5
11716
3.3
methyl o-chlorobenzoylformate
Sulfolobus acidocaldarius
Q4J702
65C, pH 5.5; pH 5.5, 65C
42134
14.1
methyl oxo(phenyl)acetate
Thermus thermophilus
-
pH 10.5, 65C
144721
320
n-butanol
Geobacillus stearothermophilus
-
wild-type, pH 8.0, 60C
629
3.5 - 380
NAD+
7
12.9 - 4500
NADH
8
117.9 - 278
NADP+
10
720 - 5724
NADPH
5
450.8
octanal
Geobacillus thermodenitrificans
A4IP64, A4ISB9
cosubstrate NADPH, pH 8.0, 60C
837
333 - 1063
phenylacetaldehyde
769
0.1
tert-butyl acetoacetate
Aeropyrum pernix
-
pH 8.0, 60C
194812
1.13
tetralin-1-ol
Sulfolobus acidocaldarius
-
65C, pH 10.5
42136
264 - 1543
Valeraldehyde
1481