1.1.1.1: alcohol dehydrogenase

This is an abbreviated version, for detailed information about alcohol dehydrogenase, go to the full flat file.

Reaction

a primary alcohol
+
NAD+
=
an aldehyde
+
NADH
+
H+

Synonyms

(R)-specific alcohol dehydrogenase, 40 kDa allergen, Aadh1, ADH, ADH 1, ADH class III, ADH I, ADH II, ADH-10, ADH-A, ADH-A2, ADH-B2, ADH-C2, ADH-HT, ADH-I, ADH1, ADH1B, ADH1C, ADH1C*1, ADH1C*2, Adh1p, ADH2, ADH3, ADH4, ADH5, ADH6Hp, ADH8, AdhA, AdhB, AdhC, AdhD, AdhE, ADS1, AFPDH, alcohol dehydrogenase, alcohol dehydrogenase (NAD), alcohol dehydrogenase 1, alcohol dehydrogenase 10, alcohol dehydrogenase 2, alcohol dehydrogenase 3, alcohol dehydrogenase 5, alcohol dehydrogenase I, alcohol dehydrogenase II, Alcohol dehydrogenase-B2, alcohol dependent dehydrogenase, alcohol-aldehyde/ketone oxidoreductase, NAD+-dependent, alcohol:NAD+ oxidoreductase, aldehyde dehydrogenase, aldehyde reductase, aldehyde/alcohol dehydrogenase, ALDH, aliphatic alcohol dehydrogenase, APE2239, APE_2239.1, ARAD1B16786p, bifunctional alcohol/aldehyde dehydrogenase, CHY1186, class I ADH, class I ALDH, class II ADH, class III ADH, class III alcohol dehydrogenase, class IV ADH, Cm-ADH2, Cthe_0423, DADH, dehydrogenase, alcohol, ethanol dehydrogenase, FALDH, FDH, Gastric alcohol dehydrogenase, Glutathione-dependent formaldehyde dehydrogenase, GSH-FDH, HLAD, HpADH3, HtADH, HvADH1, HVO_2428, iron-containing alcohol dehydrogenase, KlADH4, KlDH3, KmADH3, KmADH4, long-chain alkyl alcohol dehydrogenase, LSADH, medium chain alcohol dehydrogenase, medium-chain NAD+-dependent ADH, medium-chain secondary alcohol dehydrogenase, NAD(H)-dependent alcohol dehydrogenase, NAD+-ADH, NAD+-dependent (S)-stereospecific alcohol dehydrogenase, NAD+-dependent alcohol dehydrogenase, NAD-dependent alcohol dehydrogenase, NAD-dependent medium-chain ADH, NAD-specific aromatic alcohol dehydrogenase, NADH-alcohol dehydrogenase, NADH-aldehyde dehydrogenase, NADH-dependent alcohol dehydrogenase, Octanol dehydrogenase, PF0991 protein, PF1960, primary alcohol dehydrogenase, Retinol dehydrogenase, SaADH, SaADH2, Saci_1232, SADH, SCAD, sec-ADH A, short-chain ADH, short-chain NAD(H)-dependent dehydrogenase/reductase, SSADH, SsADH-10, SSO2536, ST0053, Ta1316 ADH, TaDH, TBADH, Teth39_0206, Teth39_0218, Teth514_0627, TK0845, Tsac_0416, Y-ADH, YADH, YADH-1, yeast alcohol dehydrogenase, YLL056C

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.1 alcohol dehydrogenase

KCat KM Value

KCat KM Value on EC 1.1.1.1 - alcohol dehydrogenase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
11
(2E)-but-2-en-1-ol
pH 8.0, 55C
-
122
(2E)-but-2-enal
pH 6.5, 65C
2.98
(R)-1-indanol
65C, pH 8.0; pH 8.0, 65C
10.5
(R)-alpha-tetralol
65C, pH 8.0; pH 8.0, 65C
2.14 - 14.6
(S)-1-indanol
0.06
(S)-1-phenylethanol
-
pH 10.5, 65C
2 - 13.6
(S)-alpha-tetralol
0.01
1,2-propanediol
-
pH 8.0, 60C, recombinant enzyme
0.01
1,3-Propanediol
-
pH 9.0, 60C, recombinant enzyme
0.69
1-butanol
-
pH 8.0, 60C
2.5
1-Hexanol
-
pH 8.0, 60C
0.71
1-Indanol
-
65C, pH 10.5
0.3
1-Indanone
-
pH 10.5, 65C
67.2
1-Octanol
cosubstrate NADP+, pH 8.0, 60C
1.1
1-Pentanol
-
pH 8.0, 60C
2.9
1-phenyl-1,2-propandione
-
pH 10.5, 65C
0.25 - 1.06
1-phenyl-1,2-propanedione
0.15
1-phenylethanol
pH 9.0, 70C
0.25
1-propanol
-
pH 8.0, 60C
320 - 340
12-hydroxylauric acid methyl ester
-
4700
12-oxolauric acid methyl ester
-
wild-type, pH 8.0, 60C
-
0.27
2',3',4',5',6'-pentafluoroacetophenone
-
65C, pH 5.0
0.27 - 2.3
2,2,2-trifluoroacetophenone
5.91
2,2-dichloroacetophenone
-
65C, pH 5.0
0.71
2,3-Butanediol
pH 9.0, 70C
0.46
2-butanol
-
pH 8.0, 60C
2.7
2-decanone
-
pH 8.0, 60C
0.62
2-Heptanone
-
pH 8.0, 60C
0.22
2-Hexanone
-
pH 8.0, 60C
3.3
2-nonanone
-
pH 8.0, 60C
2.6
2-Octanone
-
pH 8.0, 60C
0.79
2-Pentanol
-
pH 8.0, 60C
0.15
2-Pentanone
-
pH 8.0, 60C
0.097 - 5
2-propanol
0.06
3-methylcyclohexanone
65C, pH 5.5
389 - 1036
4-chloroacetophenone
0.7
4-methoxybenzaldehyde
-
pH 6.0, 65C
0.026 - 0.53
4-methoxybenzyl alcohol
0.54
4-methoxyphenylacetone
-
pH 8.0, 60C
0.048 - 70000
acetaldehyde
0.45
acetoin
pH 6.0, 70C
392 - 1055
acetophenone
1.3
alpha-tetralone
-
pH 10.5, 65C
3.66 - 899
benzaldehyde
3.72
benzil
-
65C, pH 5.0
0.189 - 6.6
benzyl alcohol
0.3
butan-1-ol
cosubstrate NAD+, pH 7.0, 30C
0.7
Butan-2,3-diol
-
pH 8.8, 70C
0 - 210
Butanal
8600
Butyraldehyde
-
wild-type, pH 8.0, 60C
1640 - 2618
Capronaldehyde
1835
cinnamaldehyde
-
pH 7.7, 60C
391
cinnamyl alcohol
-
pH 7.7, 60C
0.23
cis-decahydro-1-naphthol
65C, pH 8.0
0.47 - 1.37
cycloheptanol
0.73
Cyclohexanol
-
pH 8.0, 60C
0.91
cyclohexanone
-
pH 8.0, 60C
0.017 - 6667
ethanol
1.57
ethyl 3-methyl-2-oxobutyrate
-
65C, pH 5.0
0.44 - 0.45
ethyl benzoylformate
50.1
ethyl oxo(phenyl)acetate
-
pH 10.5, 65C
-
0.034
formaldehyde
-
pH 7.0, 30C
0.034
furfural
-
pH 7.0, 30C
0.21
glycolaldehyde
-
pH 7.0, 30C
31
isatin
65C, pH 5.5; pH 5.5, 65C
20.5
isoborneol
-
65C, pH 10.5
0.95
methyl benzoylformate
65C, pH 5.5
3.3
methyl o-chlorobenzoylformate
65C, pH 5.5; pH 5.5, 65C
14.1
methyl oxo(phenyl)acetate
-
pH 10.5, 65C
320
n-butanol
-
wild-type, pH 8.0, 60C
3.5 - 380
NAD+
12.9 - 4500
NADH
117.9 - 278
NADP+
720 - 5724
NADPH
450.8
octanal
cosubstrate NADPH, pH 8.0, 60C
333 - 1063
phenylacetaldehyde
0.018
propanal
-
pH 7.0, 30C
0.1
tert-butyl acetoacetate
-
pH 8.0, 60C
1.13
tetralin-1-ol
-
65C, pH 10.5
264 - 1543
Valeraldehyde