1.1.1.1: alcohol dehydrogenase

This is an abbreviated version, for detailed information about alcohol dehydrogenase, go to the full flat file.

Reaction

a primary alcohol
+
NAD+
=
an aldehyde
+
NADH
+
H+

Synonyms

(R)-specific alcohol dehydrogenase, 40 kDa allergen, Aadh1, acetaldehyde-alcohol dehydrogenase, ADH, ADH 1, ADH class III, ADH I, ADH II, ADH-10, ADH-A, ADH-A2, ADH-B2, ADH-C2, ADH-HT, ADH-I, ADH1, ADH1B, ADH1C, ADH1C*1, ADH1C*2, Adh1p, ADH2, ADH3, ADH4, ADH5, ADH6Hp, ADH8, AdhA, AdhB, AdhC, AdhD, AdhE, ADHES77, ADS1, AFPDH, alcohol dehydrogenase, alcohol dehydrogenase (NAD), alcohol dehydrogenase 1, alcohol dehydrogenase 10, alcohol dehydrogenase 2, alcohol dehydrogenase 3, alcohol dehydrogenase 5, alcohol dehydrogenase GroES domain protein, alcohol dehydrogenase I, alcohol dehydrogenase II, Alcohol dehydrogenase-B2, alcohol dependent dehydrogenase, alcohol-aldehyde/ketone oxidoreductase, NAD+-dependent, alcohol:NAD+ oxidoreductase, aldehyde dehydrogenase, aldehyde reductase, aldehyde/alcohol dehydrogenase, ALDH, aliphatic alcohol dehydrogenase, alpha-ketoaldehyde dehydrogenase, APE2239, APE_2239.1, ARAD1B16786p, bifunctional acetaldehyde-alcohol dehydrogenase, bifunctional alcohol/aldehyde dehydrogenase, CHY1186, class I ADH, class I ALDH, class II ADH, class III ADH, class III alcohol dehydrogenase, class IV ADH, Cm-ADH2, Cthe_0423, DADH, dehydrogenase, alcohol, ethanol dehydrogenase, FALDH, FDH, Gastric alcohol dehydrogenase, Glutathione-dependent formaldehyde dehydrogenase, GSH-FDH, HLAD, HpADH3, HtADH, HvADH1, HVO_2428, iron-containing alcohol dehydrogenase, KlADH4, KlDH3, KmADH3, KmADH4, long-chain alkyl alcohol dehydrogenase, LSADH, medium chain alcohol dehydrogenase, medium-chain NAD+-dependent ADH, medium-chain secondary alcohol dehydrogenase, MGD, NAD(H)-dependent alcohol dehydrogenase, NAD+-ADH, NAD+-dependent (S)-stereospecific alcohol dehydrogenase, NAD+-dependent alcohol dehydrogenase, NAD+-linked alcohol dehydrogenase 1, NAD+-linked methylglyoxal dehydrogenase, NAD-dependent alcohol dehydrogenase, NAD-dependent medium-chain ADH, NAD-specific aromatic alcohol dehydrogenase, NADH-alcohol dehydrogenase, NADH-aldehyde dehydrogenase, NADH-dependent alcohol dehydrogenase, Octanol dehydrogenase, Pcal_1311, PF0991 protein, PF1960, primary alcohol dehydrogenase, Retinol dehydrogenase, SaADH, SaADH2, Saci_1232, SADH, SCAD, sec-ADH A, short-chain ADH, short-chain NAD(H)-dependent dehydrogenase/reductase, SSADH, SsADH-10, SSO2536, ST0053, Ta1316 ADH, TaDH, TBADH, Teth39_0206, Teth39_0218, Teth514_0627, TK0845, Tsac_0416, Y-ADH, YADH, YADH-1, yeast alcohol dehydrogenase, YLL056C

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.1 alcohol dehydrogenase

KCat KM Value

KCat KM Value on EC 1.1.1.1 - alcohol dehydrogenase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
11
(2E)-but-2-en-1-ol
pH 8.0, 55C
122
(2E)-but-2-enal
pH 6.5, 65C
2.98
(R)-1-indanol
65C, pH 8.0; pH 8.0, 65C
10.5
(R)-alpha-tetralol
65C, pH 8.0; pH 8.0, 65C
2.14 - 14.6
(S)-1-indanol
0.06
(S)-1-phenylethanol
-
pH 10.5, 65C
2 - 13.6
(S)-alpha-tetralol
0.01
1,2-propanediol
-
pH 8.0, 60C, recombinant enzyme
0.01
1,3-Propanediol
-
pH 9.0, 60C, recombinant enzyme
5.5
1,4-Butanediol
pH 10, 60C
0.69
1-butanol
-
pH 8.0, 60C
2.5
1-Hexanol
-
pH 8.0, 60C
0.71
1-Indanol
-
65C, pH 10.5
0.3
1-Indanone
-
pH 10.5, 65C
67.2
1-Octanol
cosubstrate NADP+, pH 8.0, 60C
1.1
1-Pentanol
-
pH 8.0, 60C
2.9
1-phenyl-1,2-propandione
-
pH 10.5, 65C
0.25 - 1.06
1-phenyl-1,2-propanedione
0.15
1-phenylethanol
pH 9.0, 70C
0.25
1-propanol
-
pH 8.0, 60C
320 - 340
12-hydroxylauric acid methyl ester
4700
12-oxolauric acid methyl ester
-
wild-type, pH 8.0, 60C
0.27
2',3',4',5',6'-pentafluoroacetophenone
-
65C, pH 5.0
0.27 - 2.3
2,2,2-trifluoroacetophenone
5.91
2,2-dichloroacetophenone
-
65C, pH 5.0
0.71
2,3-Butanediol
pH 9.0, 70C
0.46
2-butanol
-
pH 8.0, 60C
2.7
2-decanone
-
pH 8.0, 60C
0.62
2-Heptanone
-
pH 8.0, 60C
0.22
2-Hexanone
-
pH 8.0, 60C
3.3
2-nonanone
-
pH 8.0, 60C
2.6
2-Octanone
-
pH 8.0, 60C
0.79
2-Pentanol
-
pH 8.0, 60C
0.15
2-Pentanone
-
pH 8.0, 60C
0.097 - 5
2-propanol
0.06
3-methylcyclohexanone
65C, pH 5.5
389 - 1036
4-chloroacetophenone
0.7
4-methoxybenzaldehyde
-
pH 6.0, 65C
0.026 - 0.53
4-methoxybenzyl alcohol
0.54
4-methoxyphenylacetone
-
pH 8.0, 60C
0.048 - 70000
acetaldehyde
0.45
acetoin
pH 6.0, 70C
392 - 1055
acetophenone
1.3
alpha-tetralone
-
pH 10.5, 65C
3.66 - 899
benzaldehyde
3.72
benzil
-
65C, pH 5.0
0.189 - 6.6
benzyl alcohol
0.3
butan-1-ol
cosubstrate NAD+, pH 7.0, 30C
0.7
Butan-2,3-diol
-
pH 8.8, 70C
0 - 210
Butanal
8600
Butyraldehyde
-
wild-type, pH 8.0, 60C
1640 - 2618
Capronaldehyde
1835
cinnamaldehyde
-
pH 7.7, 60C
391
cinnamyl alcohol
-
pH 7.7, 60C
0.23
cis-decahydro-1-naphthol
65C, pH 8.0
0.47 - 1.37
cycloheptanol
0.73
Cyclohexanol
-
pH 8.0, 60C
0.91
cyclohexanone
-
pH 8.0, 60C
0.007 - 6667
ethanol
1.57
ethyl 3-methyl-2-oxobutyrate
-
65C, pH 5.0
0.44 - 0.45
ethyl benzoylformate
50.1
ethyl oxo(phenyl)acetate
-
pH 10.5, 65C
0.034
formaldehyde
-
pH 7.0, 30C
0.034
furfural
-
pH 7.0, 30C
139
Glutaraldehyde
pH 6, 60C
0.21
glycolaldehyde
-
pH 7.0, 30C
31
isatin
65C, pH 5.5; pH 5.5, 65C
20.5
isoborneol
-
65C, pH 10.5
0.95
methyl benzoylformate
65C, pH 5.5
3.3
methyl o-chlorobenzoylformate
65C, pH 5.5; pH 5.5, 65C
14.1
methyl oxo(phenyl)acetate
-
pH 10.5, 65C
320
n-butanol
-
wild-type, pH 8.0, 60C
3.5 - 380
NAD+
12.9 - 4500
NADH
117.9 - 278
NADP+
720 - 5724
NADPH
450.8
octanal
cosubstrate NADPH, pH 8.0, 60C
333 - 1063
phenylacetaldehyde
0.018
propanal
-
pH 7.0, 30C
0.1
tert-butyl acetoacetate
-
pH 8.0, 60C
1.13
tetralin-1-ol
-
65C, pH 10.5
264 - 1543
Valeraldehyde